Randomized, double-blind, placebo-controlled, linear dose, crossover study to evaluate the efficacy and safety of a green coffee bean extract in overweight subjects

Abstract

BackgroundAdult weight gain and obesity have become worldwide problems. Issues of cost and potential side effects of prescription weight loss drugs have led overweight and obese adults to try nutraceuticals that may aid weight loss. One promising nutraceutical is green coffee extract, which contains high concentrations of chlorogenic acids that are known to have health benefits and to influence glucose and fat metabolism. A 22-week crossover study was conducted to examine the efficacy and safety of a commercial green coffee extract product GCA™ at reducing weight and body mass in 16 overweight adults.MethodsSubjects received high-dose GCA (1050 mg), low-dose GCA (700 mg), or placebo in separate six-week treatment periods followed by two-week washout periods to reduce any influence of preceding treatment. Treatments were counterbalanced between subjects. Primary measurements were body weight, body mass index, and percent body fat. Heart rate and blood pressure were also measured.ResultsSignificant reductions were observed in body weight (−8.04 ± 2.31 kg), body mass index (−2.92 ± 0.85 kg/m2), and percent body fat (−4.44% ± 2.00%), as well as a small decrease in heart rate (−2.56 ± 2.85 beats per minute), but with no significant changes to diet over the course of the study. Importantly, the decreases occurred when subjects were taking GCA. Body mass index for six subjects shifted from preobesity to the normal weight range (<25.00 kg/m2).ConclusionThe results are consistent with human and animal studies and a meta-analysis of the efficacy of green coffee extract in weight loss. The results suggest that GCA may be an effective nutraceutical in reducing weight in preobese adults, and may be an inexpensive means of preventing obesity in overweight adults.

Effects of Green Coffee Bean Extract Supplementation on Patients with Non-Alcoholic Fatty Liver Disease: A Randomized Clinical Trial

“…NAFLD patients in the placebo group (n = 22) assigned to receive the same amount of placebo for the same time. Safety of the dose and duration of the study has been verified in previous studies (23,24). The capsules were given to the patients at the time of randomization and at the 4 th -week followup visit.…”

Nutritional intervention and impact of polyphenol on glycohemoglobin (HbA1c) in non-diabetic and type 2 diabetic subjects: Systematic review and meta-analysis

“…And so forth, relate the change in HbA1c concentration to an increase in polyphenols intake. In this case, only 7 (Balzer et al, 2008;Curtis et al, 2012;Fenercioglu et al, 2010;Kudolo et al, 2005;Pan et al, 2007;Toolsee et al, 2013;Vinson et al, 2012) of the trial included in the meta-analysis included polyphenol metabolites analysis or antioxidant capacity assay.…”

Green Coffee Bean Extract as a Weight Loss Supplement

“…The results of the study showed significant reductions in body weight, body mass index, and percent body fat, but with no significant alterations in dietary intakes over the course of the study. Finally, this study suggested that commercial green coffee extract product GCA ™ might be an effective nutraceuticals in reducing weight in pre-obese adults, and might be an inexpensive means of preventing obesity in overweight adults [28]. The results of a systematic review and metaanalysis of randomized clinical trials revealed a significant difference in body weight in GCE compared with placebo (mean difference: -2.47 kg; 95% CI: -4.23, -0.72).…”

“…Several human clinical trials have also conducted to examine the efficacy and safety of commercial GCE at reducing weight and body mass in overweight and obese adults [24][25][26][27][28]. The results from a clinical study performed on 30 overweight people showed consumption of instant coffee enriched with cholorogenic acid for 12-week induced a significant reduction in body mass index and body fat, compared with the control [26].…”

“…It seems that the beneficial effects of green coffee in relation to weight loss attributed to its cholorogenic acid content [28,29]. Cholorogenic acids have high bioavailability in humans [30,31].…”