Randomized, double-blind, multicenter, controlled trial of ibuprofen versus acetaminophen (paracetamol) and placebo for treatment of symptoms of tonsillitis and pharyngitis in children

A Randomized, Controlled Trial of Acetaminophen, Ibuprofen, and Codeine for Acute Pain Relief in Children With Musculoskeletal Trauma

“…16,26 For example, ibuprofen has been shown to be superior to acetaminophen for pain control in tonsillitis 26 and for pain related to migraines. 16 Two studies have compared pain relief with ibuprofen to an acetaminophen-codeine combined preparation 7,8 post tonsillectomy.…”

Ibuprofen: pharmacology, efficacy and safety

“…These include pain from post-dental extraction (Moore et al 1985), tonsillo-pharyngitis (Bertin et al 1991), otitis media (Bertin et al 1996), migraine (Hämäläinen et al 1997;Annequin and Tourniaire 2005;Géraud et al 2004;Cuvellier et al 2005), orthodontic separator placement or orthodontic pain (Bernhardt et al 2001;Bird et al 2007;Bradley et al 2007) in which ibuprofen has equivalent or greater efficacy than paracetamol (Table 12). However, a meta-analysis by Perrott et al (2004) concluded that ibuprofen was superior as an antipyretic compared with paracetamol.…”

Efficacy and Safety of Acetaminophen vs Ibuprofen for Treating Children's Pain or Fever

“…Otherwise relevant studies were excluded if any prior or concurrent medication was a potential confound (eg, lidocaine, codeine, and others), if the data were already included in another study, or if insufficient data were provided to calculate a value for the relevant outcome measures. The latter criterion resulted in the exclusion of 3 studies from the pain analysis [17][18][19] and 1 from the fever analysis 20 (but did not prohibit their inclusion in the safety analysis), and in the exclusion of 1 study from the safety analysis. 21 For multidose studies, we included only the data for the first dose in the pain and fever analyses.…”

“…8,9,13,14,[17][18][19][20]22,[26][27][28][29][30][31][32][33] Studies were typically single-dose, randomized, each drug fell within the recommended range for clinical practice.…”