Randomized, double-blind, controlled study of glycyl-glutamine-dipeptide in the parenteral nutrition of patients with acute leukemia undergoing intensive chemotherapy

Pilot Study: Effects of Parenteral Glutamine Dipeptide Supplementation on Neutrophil Functions and Prevention of Chemotherapy-Induced Side-Effects in Acute Myeloid Leukaemia Patients

“…The present study agrees with the findings of Scheid et al, 15 who showed an improvement in the duration of neutropenia in AML patients after supplementing TPN with glycyl-glutamine. A recovery in the leucocyte count, however, is just one aspect of the body's natural defence mechanisms.…”

“…20,21 Although not statistically significant, the patients treated with Gln in the present study tended to be older than those in the control group, which may have influenced the mean duration of neutropenia, lymphopenia, leucopenia and the effects of Gln supplementation, and might also have impacted on the length of hospital stay, as reported elsewhere. 15,22 In contrast, however, Ziegler et al 6 found the length of hospital stay of younger patients (≤ 49 years old) in a glutamine-supplemented group to be significantly shorter than the control.…”

Diagnosis, incidence, and outcomes of suspected typhlitis in oncology patients—experience in a tertiary pediatric surgical center in the United Kingdom

“…The multidrug regimens followed for most pediatric malignancies make it difficult to definitively establish a causal role of any agent in the process. Therapeutic measures including selective decontamination and enteral cytoprotective agents including glutamine have been previously suggested in neutropenic patients [28,29] to minimize the potential side effects of chemotherapy agents on the gastrointestinal tract. However, further studies are needed to provide evidence for their clinical use in typhlitis.…”

Non-surgical oncology – Guidelines on Parenteral Nutrition, Chapter 19

“…In a randomised study of patients with acute myeloid leukaemia requiring PN supplementation with glutamine (20 g) resulted in a more rapid recovery of neutrophils after myelosuppressive chemotherapy, but no reduction in the incidence of neutropenic fever and no improvement in other immunological parameters [122] (Ib). …”