Randomized dose‐ranging pilot trial of omega‐3 fatty acids for postpartum depression

Freeman, Marlene P.; Hibbeln, Joseph R.; Wisner, Katherine L.; Brumbach, Barbara H.; Watchman, Marcy; Gelenberg, Alan J.

doi:10.1111/j.1600-0447.2005.00660.x

Cited by 181 publications

(132 citation statements)

References 31 publications

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“…Freeman et al found decreases in diagnosed major depression (98) and diagnosed postpartum depression (99) following different doses of EPA þ DHA, Osher et al (100) found decreases in bipolar depression following supplementation with EPA, and Wozniak et al (101) found decreases in diagnosed childhood bipolar depression following supplementation with EPA þ DHA. Wozniak et al (101) also found decreases in mania and psychotic symptoms following supplementation and Sagduyu et al (102) found decreases in mania and bipolar symptoms following supplementation with EPA þ DHA.…”

Section: Trial Evidencementioning

confidence: 99%

“…However, the biochemistry underlying depression, for example, may be very different to the biochemistry underlying anxiety or aggression. Similarly, DHA deficiency is thought to contribute predominantly to the development of postpartum depression (98,99) , yet DHA supplementation has not been the focus of study for other forms of depression. Differences between and within trials also exist in their definitions and measurement of outcome mood.…”

Section: Other Mood and Behavioural Disordersmentioning

confidence: 99%

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Is there a role forn-3 long-chain polyunsaturated fatty acids in the regulation of mood and behaviour? A review of the evidence to date from epidemiological studies, clinical studies and intervention trials

2008

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Selected biochemical evidence suggests a potential role for n-3 long-chain PUFA (n-3PUFA) in the regulation of mood and behaviour. The present paper reviews the relevant evidence, to date, from epidemiological studies, clinical studies and intervention trials. Most evidence is available investigating a role for n-3PUFA in depression, depressive illness and suicidal behaviour, but work is also available on anxiety and anxiety-related disorders, fatigue and fatigue-related disorders, aggression, hostility and anti-social behaviour, inattention, impulsivity and attention deficit hyperactivity disorder and schizophrenic disorders. For all these aspects of mood and behaviour, the evidence available is currently limited and highly inconsistent, both in terms of study methodology and study findings. There is a clear need for further work in this area.

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Section: Trial Evidencementioning

confidence: 99%

Section: Other Mood and Behavioural Disordersmentioning

confidence: 99%

Is there a role forn-3 long-chain polyunsaturated fatty acids in the regulation of mood and behaviour? A review of the evidence to date from epidemiological studies, clinical studies and intervention trials

2008

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“…Epidemiological studies [5,6], case-control studies [7][8][9][10][11][12] , and clinical trials [13][14][15][16][17][18] all suggest that n-3 PUFAs might play an important role in major depressive disorder (MDD). Moreover, genotypes of the key enzymes for phospholipids metabolism, such as Phospholipase A2 (PLA2) and cyclo-oxygenase-2 (COX-2), have been associated with major depressive disorder [19,20] and Interferon (IFN)-α induced depression [21].…”

Section: Introductionmentioning

confidence: 99%

BanI polymorphism of cytosolic phospholipase A2 gene and somatic symptoms in medication-free acute depressed patients

Chang

Guu

Chen

et al. 2018

Prostaglandins, Leukotrienes and Essential Fatty Acids

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Somatic symptoms are commonly seen in patients with major depressive disorder (MDD) and might be associated with inflammatory activation. Cytosolic phospholipase A2 (cPLA2) and cyclo-oxygenase-2 (COX-2) are the key enzymes in the metabolism of polyunsaturated fatty acids (PUFAs), which in turn may play an important role in inflammation and somatic symptoms in depression. This study investigated the effects of BanI polymorphism of cPLA2 gene and COX-2 rs4648308 genotypes on somatic symptoms and inflammatory marker in patients with MDD.Eighty-two patients with MDD were assessed for their psychopathology including 2 psychiatric and somatic symptoms, BanI polymorphism of cPLA2 and COX-2 rs4648308 genotypes and CRP levels. The results revealed that MDD patients with the cPLA2 BanI GG genotypes had higher somatic symptoms and higher levels of C-reactive protein (CRP), while no differences were found among the COX-2 rs4648308 genotypes. Inflammatory process, such as arachidonic acid cascade pathway, might help explain the effect of cPLA2 BanI polymorphism on the somatic symptoms, and may be a potential target for future investigation on treatment for MDD with somatic symptoms. However, the interpretation of the findings in this study is limited since we analyzed the data from a subset data from a larger study.

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“…Of the former, six were randomized controlled trials (Doornbos et al, 2009;Freeman et al, 2008;Llorent et al, 2003;Makrides et al, 2010;Mozurkewich et al, 2013;Rees, Austin, & Parker, 2008) and two pilot trials (Freeman et al, 2006;Marangell et al, 2004). The nine observational studies included: one ecological study (Hibbeln, 2002), a cross-sectional study (De Vriese, Christophe, & Maes, 2003), a case-control study (Browne, Scott, & Silvers, 2006), and six cohort studies (da Rocha & Kac, 2012;Markhus et al, 2013;Miyake et al, 2006;Otto, De Groot, & Hornstra, 2003;Parker et al, 2014;Strøm, Mortensen, Halldorsson, Thorsdottir, & Olsen, 2009).…”

Section: Overall Results In Context With Expectations Arising From Thmentioning

confidence: 99%

“…There were, however, some brief, non-systematic literature and article reviews which dealt with a broad range of issues related to our topic rather than addressing the n-3 PUFAs and PPD in particular in depth (Borja-Hart & Marino, 2010;Freeman, 2006;Levant, 2010;Jans, Giltay, & Willem Van der Does, 2010;Ramakrishnan, 2011;Wojcicki & Heyman, 2011).…”

Section: Introductionmentioning

confidence: 99%

Role of Omega-3 Unsaturated Fatty Acids in the Postpartum Depression: Systematic Review and Narrative Synthesis

Mougharbel¹,

Deonandan²

2016

GJHS

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Background: Postpartum depression (PPD) is a complex mental health disorder that affects women during their childbearing years. It is a serious medical condition that occurs in approximately 15% of women after birth and has an adverse effect on both the mother and the infant. Hypotheses exist relating dietary deficiencies in a pregnant or postnatal woman's diet may cause postnatal depression. It is unclear whether Omega-3 polyunsaturated fatty acids (n-3 PUFAs) are effective for treating or preventing PPD. Objectives:To assess the best available evidence to date regarding the effect of n-3 PUFAs on the etiology, prevention and treatment of postnatal depression. Methods:A systematic review and narrative synthesis was conducted in order to address the gaps in knowledge. For the systematic review, a broad search of electronic databases of published quantitative literature was conducted. The narrative synthesis consists of four elements: 1) developing a theory; 2) developing a preliminary synthesis; 3) exploring relationships in the data; 4) assessing the robustness of the synthesis. Published experimental and observational studies were accepted involving women who were pregnant or who had given birth in the previous six weeks. N-3 PUFAs was the intervention of interest and PPD was the outcome.Results: Out of 181 potential articles, a total of 17 studies met the inclusion criteria. The overwhelming majority of the studies found that n-3 PUFAs had no inverse association with PPD evaluations. Significant heterogeneity was observed among included studies. Conclusions:Overall, This systematic review and narrative synthesis failed to find a significant positive association between n-3 PUFAs intake and PPD.

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Randomized dose‐ranging pilot trial of omega‐3 fatty acids for postpartum depression

Abstract: This study was limited by small sample size and lack of placebo group. However, these results support further study of omega-3 fatty acids as a treatment for PPD.

Cited by 181 publications

References 31 publications

Is there a role forn-3 long-chain polyunsaturated fatty acids in the regulation of mood and behaviour? A review of the evidence to date from epidemiological studies, clinical studies and intervention trials

Is there a role forn-3 long-chain polyunsaturated fatty acids in the regulation of mood and behaviour? A review of the evidence to date from epidemiological studies, clinical studies and intervention trials

BanI polymorphism of cytosolic phospholipase A2 gene and somatic symptoms in medication-free acute depressed patients

Role of Omega-3 Unsaturated Fatty Acids in the Postpartum Depression: Systematic Review and Narrative Synthesis

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