Randomized controlled trials covering pharmaceutical care and medicines management: A systematic review of literature

Babar, Zaheer Ud-Din; Kousar, Rehana; Murtaza, Ghulam; Azhar, Saira; Khan, Shujaat Ali; Curley, Louise E.

doi:10.1016/j.sapharm.2017.06.008

Cited by 34 publications

(29 citation statements)

References 69 publications

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“…According to the participants, the presence of a specialist pharmacist in their health care team and the implementation of pharmaceutical care may positively influence the adherence of the patients to their treatment. This was consistent with other studies which concluded that applying pharmaceutical care services shown positive outcomes with improving medication use, adherence and surrogate outcome 30‐32 . Pharmaceutical care services were found to give the pharmacists the opportunity to improve HIV patients adherence rate and to enhance treatment response with higher CD4 percentage 32 .…”

Section: Discussionsupporting

confidence: 90%

An assessment of HIV patient's adherence to treatment and need for pharmaceutical care in Jordan

et al. 2020

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Objective The objective of the present study was to explore the barriers and supporting factors for adherence among HIV patients and to explore their needs for pharmaceutical care services. Methods This study utilizes in‐depth interviews with HIV patients. Out of 50 patients approached, a total of 30 patients agreed to participate in the study. The researchers used a predesigned topic guide. The interview guide included two parts; the first one focused on the assessment of HIV patients' adherence to their treatment. The second part focused on patients' need for pharmaceutical care services. Results Three main themes emerged from the interviews. Those included patient‐related factors, medication‐related factors and Healthcare professional related factors. This study found that a number of barriers that decreased adherence in HIV patients included stigmatisation, fear from disclosure, dosage form of the drug, adverse events and poor cooperation from healthcare professionals. On the other side supporting factors included family and friends support, electronic mobile reminders, feeling responsible to raising children, religious beliefs and feeling improvement while using therapy. Furthermore, the study illustrated that HIV patients need to have a specialist pharmacist in their healthcare team who delivers specialised pharmaceutical care services which may increase patients' adherence. Conclusions The current study reveals a margin for medication adherence improvement in HIV patients. Patients in this study demonstrated the need for a pharmaceutical care. Future disease management and clinical pharmacy services programs should address the current study findings in order to improve the health service for HIV patients.

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Section: Discussionsupporting

confidence: 90%

An assessment of HIV patient's adherence to treatment and need for pharmaceutical care in Jordan

et al. 2020

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“…Mathumalar et al (2011), Patterson et al (2012), Lee et al (2013), Sáez-Benito et al (2013), Cooper et al (2015), Olaniyan et al (2015), and Babar et al (2017) presented evidence for clinical outcomes related to the reduction of polypharmacy, medication errors, and prescription of potentially inappropriate medications; improvement of the use of appropriate and safe medications; and improvement of adherence. Lee et al (2013) also found data on clinical outcomes regarding the reduction of drug-related problems, adverse drug events, adverse drug reactions, drug-drug interactions, and drug-related negative health outcomes.…”

Section: Resultsmentioning

confidence: 99%

Community-Level Pharmaceutical Interventions to Reduce the Risks of Polypharmacy in the Elderly: Overview of Systematic Reviews and Economic Evaluations

Soler

Barreto

2019

Front. Pharmacol.

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Background: Patients over 65 years of age taking multiple medications face several risks, and pharmaceutical interventions can be useful to improve quality of care and reduce those risks. However, there is still no consensus on the effectiveness of these interventions aimed at promoting changes in clinical, epidemiological, economic, and humanistic outcomes for various service delivery, organizational, financial, and implementation-based interventions. The objective of this overview of systematic reviews was to summarize evidence on the effectiveness of community-level pharmaceutical interventions to reduce the risks associated with polypharmacy in the population over 65 years of age. Method: This overview used a previously described protocol to search for systematic review articles, with and without meta-analysis, and economic evaluations, without any language or time restrictions, including articles published up to May 2018. The following databases were searched: the Cochrane Library, Epistemonikos, Health Evidence, Health Systems Evidence, Virtual Health Library, and Google Scholar. The basic search terms used were “elderly,” “polypharmacy,” and “pharmaceutical interventions.” The findings for outcomes of interest were categorized using a taxonomy for health policies and systems. Equity-related questions were also investigated. The studies were evaluated for methodological quality and produced a narrative synthesis. Results: A total of 642 records were retrieved: 50 from Health Evidence, 197 from Epistemonikos, 194 from Cochrane, 116 from Health Systems Evidence, and 85 from the Virtual Health Library. Of these, 16 articles were selected: 1 overview of systematic reviews, 12 systematic reviews, and 3 economic evaluations. There is evidence of improvement in clinical, epidemiological, humanistic, and economic outcomes for various types of community-level pharmaceutical interventions, but differences in observed outcomes may be due to study designs, primary study sample sizes, risk of bias, difficulty in aggregating data, heterogeneity of indicators and quality of evidence included in the systematic reviews that were assessed. It is necessary to optimize the methodological designs of future primary and secondary studies. Conclusion: Community-level pharmaceutical interventions can improve various clinical, epidemiological, humanistic and economic outcomes and potentially reduce risks associated with polypharmacy in the elderly population.

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“…The underlying recommendation was to move toward a patient-centered philosophy of clinical practice aimed at improving therapy outcomes. From its inception, the primary goal of pharmaceutical care was to give pharmacists the opportunity to move beyond the role of merely dispensing the right drug [21]. Later on, even the term itself was perceived as a limit against the spread of pharmaceutical care beyond the pharmacists' professional world [22].…”

Section: Clinical Pharmacy and Pharmaceutical Carementioning

confidence: 99%

Do European pharmacists really have to trespass on medicine?

2020

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Randomized controlled trials covering pharmaceutical care and medicines management: A systematic review of literature

Cited by 34 publications

References 69 publications

An assessment of HIV patient's adherence to treatment and need for pharmaceutical care in Jordan

An assessment of HIV patient's adherence to treatment and need for pharmaceutical care in Jordan

Community-Level Pharmaceutical Interventions to Reduce the Risks of Polypharmacy in the Elderly: Overview of Systematic Reviews and Economic Evaluations

Do European pharmacists really have to trespass on medicine?

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