Randomized, controlled trial testing the effectiveness and safety of 2.5% and 5% benzoyl peroxide for the treatment of pitted keratolysis

Leeyaphan, Charussri; Limphoka, Pichaya; Kiratiwongwan, Rungsima; Ongsri, Punyawee; Bunyaratavej, Sumanas

doi:10.1080/09546634.2019.1708244

Cited by 5 publications

(5 citation statements)

References 12 publications

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“…However, most patients require antiseptic or antibiotic treatment for odor reduction and clinical improvement. Randomized controlled trials have shown that topical benzoyl peroxide gel can improve PK in 63.8% and 69% of patients using 2.5% and 5% formulations, respectively 8 …”

Section: Discussionmentioning

confidence: 99%

“…Randomized controlled trials have shown that topical benzoyl peroxide gel can improve PK in 63.8% and 69% of patients using 2.5% and 5% formulations, respectively. 8 Approximately 80% of PK patients achieved complete resolution with erythromycin gel or chlorhexidine treatment. A previous study found that while chlorhexidine scrub and erythromycin gel had similar clinical improvements and odor reduction, chlorhexidine scrub was more cost-effective.…”

Section: Discussionmentioning

confidence: 99%

“…Hyperhidrosis is a well‐established risk factor for PK development 2,3 . Various topical agents have been recommended for PK treatment, such as erythromycin gel, benzoyl peroxide, mupirocin ointment, clindamycin solution, and chlorhexidine scrub 8–12 . In addition to these treatments, lifestyle modifications are crucial in PK treatment and prevention 3,13 …”

Section: Introductionmentioning

confidence: 99%

“…2,3 Various topical agents have been recommended for PK treatment, such as erythromycin gel, benzoyl peroxide, mupirocin ointment, clindamycin solution, and chlorhexidine scrub. [8][9][10][11][12] In addition to these treatments, lifestyle modifications are crucial in PK treatment and prevention. 3,13 Chlorhexidine, an antiseptic effective against gram-positive bacteria, gram-negative bacteria, and fungi, 14 is widely available in Thai hospitals at a reasonable price.…”

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confidence: 99%

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Randomized controlled trial and cost‐effectiveness analysis: Comparing chlorhexidine scrub, ZnO‐nanoparticle socks, and their combination in pitted keratolysis treatment

Leeyaphan,

Kulthanachairojana,

Taychakhoonavudh

et al. 2023

The Journal of Dermatology

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A cost‐effective treatment for pitted keratolysis (PK) is the use of 4% chlorhexidine scrub. Zinc oxide nanoparticle (ZnO‐NP)‐coated socks have also shown efficacy in PK prevention. In this study, we aimed to assess the cost‐effectiveness and safety of combined 4% chlorhexidine scrub and ZnO‐NP‐coated sock treatment compared to monotherapy. This randomized, controlled trial included 60 male security guards and hospital porters aged ≥18 with PK. Participants were randomly assigned to one of three treatment groups: 4% chlorhexidine scrub, ZnO‐NP‐coated socks, or combination therapy. Treatment outcomes were evaluated after 4 weeks. Incremental cost‐effectiveness ratios (ICERs) were calculated using cost‐utility analysis. The greatest reduction in visual analog scale scores for foot odor was observed in the combination therapy group, but it was nonsignificant (P = 0.186). Clinical improvement was observed across all groups. The cost‐utility analysis revealed that chlorhexidine scrub and regular socks were the least expensive options. The placebo and ZnO‐NP‐coated sock group had an ICER of US $31 082/quality‐adjusted life years (QALYs) gain, while the combination therapy gained US $45 105/QALYs compared to the chlorhexidine scrub and regular sock group. Based on our findings, for the treatment of PK, 4% chlorhexidine scrub remains the most cost‐effective choice.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Randomized controlled trial and cost‐effectiveness analysis: Comparing chlorhexidine scrub, ZnO‐nanoparticle socks, and their combination in pitted keratolysis treatment

Leeyaphan,

Kulthanachairojana,

Taychakhoonavudh

et al. 2023

The Journal of Dermatology

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“…Pitted keratolysis (PK) is a superficial bacterial infection caused by many organisms, such as Corynebacterium spp., Actinomyces spp., Dermatophilus spp., and Kytococcus sedentarius [ 1 , 2 ]. Patients usually complain of malodor and excessive sweating and sometimes of a burning sensation [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

The Correlations between Clinical Features, Dermoscopic and Histopathological Findings, and Treatment Outcomes of Patients with Pitted Keratolysis

Pattanaprichakul

Kulthanan

Bunyaratavej

et al. 2021

BioMed Research International

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Background. Pitted keratolysis (PK) is a superficial bacterial infection diagnosed mainly by clinical manifestations. Current data on its dermoscopic and histopathological findings, and the correlation of those findings, are limited. Objectives. To evaluate the clinical manifestations, dermoscopic, and histopathological findings of PK and to determine the correlations. Methods. Forty naval cadets with PK and five cadets with normal feet were enrolled this cohort study and provided informed consent. Dermoscopy was independently applied and evaluated by 2 dermatologists. Shave biopsies were performed on 37 patients with PK. Results. Pits were the most common dermoscopic finding (88.1%). The dermoscope had more sensitivity for the detection of PK than the naked eye examinations. Apart from the pits and the presence of bacteria, the most common histopathological finding for PK was color alteration of keratin. The presence of bacteria correlated with interrupted dermatoglyphic lines and the color alteration of keratin. Moreover, the presence of bacteria at the base of pits was related to worse treatment outcomes. Conclusions. Dermoscopy is a useful tool for PK diagnosis. Color alteration of keratin is another histopathological finding for PK. The presence of bacteria is associated with worse treatment outcomes.

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Putjeszolen/pitted keratolysis

de Regt,

Exter

2023

Kleine Kwalen in De Huisartsenpraktijk

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Randomized, controlled trial testing the effectiveness and safety of 2.5% and 5% benzoyl peroxide for the treatment of pitted keratolysis

Cited by 5 publications

References 12 publications

Randomized controlled trial and cost‐effectiveness analysis: Comparing chlorhexidine scrub, ZnO‐nanoparticle socks, and their combination in pitted keratolysis treatment

Randomized controlled trial and cost‐effectiveness analysis: Comparing chlorhexidine scrub, ZnO‐nanoparticle socks, and their combination in pitted keratolysis treatment

The Correlations between Clinical Features, Dermoscopic and Histopathological Findings, and Treatment Outcomes of Patients with Pitted Keratolysis

Putjeszolen/pitted keratolysis

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