Randomized controlled trial on treatment of bronchial asthma of qi-deficiency cold syndrome type by Pingchuan Yiqi Granule (平喘益气颗粒)

Abstract

PYG used to treat BS-QDC is effective and safe, it's effect is similar to that of RDP.

Chinese herbal medicine formula for acute asthma: A multi-center, randomized, double-blind, proof-of-concept trial

“…We speculated that PCYQ could reduce IL-5 release through inhibiting PGD2 production. One component of the PCYQ granule, licorice could inhibit production of IL-4 and IL-5 by murine memory T H 2 cells and eotaxin-1 production [41]. More importantly, PCYQ did not affect the production of antiviral cytokines (IFN-α/-β), this indicates that PCYQ may provide a more precise inhibition of cytokines involved in inflammation and fibrosis, without affecting antiviral immunity that is observed in corticosteroids [53].…”

“…The targeted sample size of 296 randomized subjects would need to be enrolled, to allow for 20% withdrawals, in order to provide 80% power to detect a difference of 40 L/min in PEF at a one-sided 0.05 level, according to our previous study [41], thus we intended to finally recruit 300 participants. The primary and secondary efficacy measures were evaluated by using the intention-to-treat (ITT) population analysis.…”

Efeitos da acupuntura e fitoterapia chinesa na qualidade de vida e nos marcadores inflamatórios de pacientes asmáticos: estudo piloto

“…Um nível de significância de p < 0,05 foi adotado para todas as análises. Os artigos publicados por Zhang Ying et al [11] e Hong Ping Zhang et al [12] utilizaram em seus estudos a fórmula chinesa de fitoterapia intitulada de Grânulo de PingchuanYiqi (PCYQ). Evidenciou-se por meio dos estudos de Zhang Ying et al [11] que não houve diferença significativa entre os dois grupos tratados para asma no período de uma semana.…”

Clinical Studies with Traditional Chinese Medicine in the Past Decade and Future Research and Development

“…Rheumatoid arthritis [49][50][51] Joint symptoms, cold pattern, heat pattern, deficiency pattern Vitiligo [52] Qi-stagnancy and blood-stasis syndrome type Impaired glucose tolerance [53] Pi-Wei dampness-heat syndrome type Irritable bowel syndrome [54] Gan-qi attacking Pi syndrome type Unstable angina pectoris [55] Phlegm and blood stasis syndrome type Post-traumatic stress disorder [56] Heart Shen disturbance Liver Qi stagnation Vascular dementia [57] Kidney deficiency and blood stagnation type Gastric ulcer [58] Pi-insufficiency and stasis-heat syndrome type Respiratory syncytial viral pneumonia [59] Phlegm-heat blocking Fei syndrome type Bronchial asthma [60] Qi-deficiency cold syndrome type stitutional deficiencies in the heart, kidney, and spleen organ systems. Liuʼs study found that Kangxin capsule can effectively improve the symptom of patients with vascular dementia, with TCM senile kidney deficiency and a blood stagnation pattern and the average value of the curative effect index of patients was higher and did not demonstrate any obvious toxic side effect [57].…”

“…Yang and coworkersʼ study on evaluation by survival analysis on the effect of TCM in treating children with respiratory syncytial viral pneumonia with TCM phlegm-heat blocking lung pattern demonstrated that the three curative parameters including comprehensive efficacy, post-treatment main symptoms score improvement and survival analysis of the main symptoms were improved in the TCM treatment [59]. In an RCT on treatment of bronchial asthma with TCM Qi-deficiency and cold pattern by taking Pingchuan Yiqi granule and Ruyi Dingchuan pill [60], the clinically controlled rate, markedly effective rate, improved rate and ineffective rate between the Pingchuan Yiqi granule group and Ruyi Dingchuan pill group showed an insignificant difference, and showed that both TCM preparations were effective in the treatment.…”