Randomized, controlled trial of slow versus rapid feeding volume advancement in preterm infants

Christensen, Robert D.; Street, Jennifer L.

doi:10.1016/j.jpeds.2005.03.024

Cited by 4 publications

(5 citation statements)

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“…Similar to our study, many of the previous studies have reported comparable rates of NEC among twins and triplets [20,37,44,45]. Similar to other care practices in neonatology, during this study period, changes in neonatal feeding practices and central line care bundles may have significantly modified the neonatal outcomes such as NEC and sepsis [34,35,[46][47][48][49][50][51][52].…”

Section: Sepsis and Necrotizing Enterocolitissupporting

confidence: 87%

Outcomes of multiple gestation births compared to singleton: analysis of multicenter KID database

Thekkeveedu

Dankhara

Desai

et al. 2021

matern health, neonatol and perinatol

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Background The available data regarding morbidity and mortality associated with multiple gestation births is conflicting and contradicting. Objective To compare morbidity, mortality, and length of stay (LOS) outcomes between multiple gestation (twin, triplet and higher-order) and singleton births. Methods Data from the national multicenter Kids’ Inpatient Database of the Healthcare Cost and Utilization Project from the years 2000, 2003, 2006, 2009, 2012, and 2016 were analyzed using a complex survey design using Statistical Analysis System (SAS) 9.4 (SAS Institute, Cary NC). Neonates with ICD9 and ICD10 codes indicating singletons, twins or triplets, and higher-order multiples were included. Mortality was compared between these groups after excluding transfer outs to avoid duplicate inclusion. To analyze LOS, we included inborn neonates and excluded transfers; who died inpatient and any neonates who appear to have been discharged less than 33 weeks PMA. The LOS was compared by gestational age groups. Results A total of 22,853,125 neonates were analyzed for mortality after applying inclusion-exclusion criteria; 2.96% were twins, and 0.13% were triplets or more. A total of 22,690,082 neonates were analyzed for LOS. Mean GA, expressed as mean (SD), for singleton, twins and triplets, were 38.30 (2.21), 36.39 (4.21), and 32.72 (4.14), respectively. The adjusted odds for mortality were similar for twin births compared to singleton (aOR: 1.004, 95% CI:0.960–1.051, p = 0.8521). The adjusted odds of mortality for triplet or higher-order gestation births were higher (aOR: 1.33, 95% CI: 1.128–1.575, p = 0.0008) when compared to the singleton births. Median LOS (days) was significantly longer in multiple gestation compared to singleton births overall (singletons: 1.59 [1.13, 2.19] vs. twins 3.29 [2.17, 9.59] vs. triplets or higher-order multiples 19.15 [8.80, 36.38], p < .0001), and this difference remained significant within each GA category. Conclusion Multiple gestation births have higher mortality and longer LOS when compared to singleton births. This population data from multiple centers across the country could be useful in counseling parents when caring for multiple gestation pregnancies.

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Section: Sepsis and Necrotizing Enterocolitissupporting

confidence: 87%

Outcomes of multiple gestation births compared to singleton: analysis of multicenter KID database

Thekkeveedu

Dankhara

Desai

et al. 2021

matern health, neonatol and perinatol

View full text Add to dashboard Cite

show abstract

“…feedings, using feeding guidelines, have been implemented and these too have been shown to improve weight gain. [13][14][15][16][17][18] We recognize that our new weight grid does not display 'ideal' weight changes, but it displays actual changes, using a large cohort of heterogeneous low birth weight (LBW) NICU patients in four different hospitals. The lack of initial weight loss we observed among the smallest neonates was not seen in the previous growth grids.…”

Section: Discussionmentioning

confidence: 99%

“…[6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] On the basis of these, we hypothesized that NICU patients cared for currently have more rapid weight gain than are displayed on the commonly used postnatal grids. [2][3][4][5] To test this we collected, from electronic records, all daily weights of all patients with birth weights 400-2600 g, born during a 30-month period, January 1, 2003-June 30, 2005, cared for in any the NICU's of the Intermountain Health Care (IHC) System.…”

Section: Introductionmentioning

confidence: 99%

Pattern of daily weights among low birth weight neonates in the neonatal intensive care unit: data from a multihospital health-care system

et al. 2005

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“…Therefore, certain authors argue that the risk of NEC should not be considered in isolation of other potential clinical outcomes while formulating feeding policies and practices for preterm infants [ 20 ]. Clinical studies have evaluated the effects of different feeding regimens on the incidence of NEC and outcomes in premature neonates [ 21 ]. The use of breast milk initially may be protective against NEC.…”

Section: Discussionmentioning

confidence: 99%

The Association of Nil Per Os (NPO) Days with Necrotizing Enterocolitis

Wang

Guo

2018

Gastroenterology Research and Practice

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Background Enteral feeds are an essential part of care for infants and may be a potential risk factor in NEC development. The present study objective was to evaluate the relationship between nil per os (NPO) and clinical outcomes in infants with NEC. Methods This was a retrospective review of 196 premature, low-birth-weight infants with NEC from January 1, 2011, to October 31, 2016, at four academic tertiary care hospitals. The patients were evaluated based on the median nil per os (NPO) days (5.6 days) in longer NPO (6.3 ± 1.1 days) versus shorter NPO groups (4.2 ± 0.9 days). Results Patients who experienced longer than 5.6 NPO days were more likely associated with perforated NEC (odds ratio (OR), 2.01; 95% confidence interval (CI), 1.07–3.76; p = 0.021), stage III NEC (OR, 1.81; 95% CI, 0.97–3.38; p = 0.042), and longer duration of mechanical ventilation (OR, 0.17; 95% CI, 0.08–0.98; p = 0.005) than the shorter duration group of 5.6 NPO days. For the secondary outcomes, there was a trend towards earlier birth (p = 0.083), longer NICU length of stay (p = 0.093), and higher mortality (p = 0.10) in the longer NPO cohort (p = 0.057). The incidence of bacterial sepsis and short bowel syndrome also increased as the length of NPO increased. There was no statistically significant difference in nutritional variables between the two groups within the in-hospital period. Conclusion Longer NPO time was associated with the severity of NEC and more injurious clinical outcomes, as demonstrated by rates of surgical intervention and duration of mechanical ventilation.

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Randomized, controlled trial of slow versus rapid feeding volume advancement in preterm infants

Cited by 4 publications

References 0 publications

Outcomes of multiple gestation births compared to singleton: analysis of multicenter KID database

Outcomes of multiple gestation births compared to singleton: analysis of multicenter KID database

Pattern of daily weights among low birth weight neonates in the neonatal intensive care unit: data from a multihospital health-care system

The Association of Nil Per Os (NPO) Days with Necrotizing Enterocolitis

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