Randomized controlled trial of Siberian ginseng for chronic fatigue

Hartz, Arthur J.; Bentler, Suzanne E.; Noyes, Russell; Hoehns, James D.; Logemann, Craig D.; Sinift, Suzanne; Butani, Yogita; Wang, W.; Brake, K.; Ernst, Michael E.; Kautzman, Holli A.

doi:10.1017/s0033291703008791

Cited by 48 publications

(41 citation statements)

References 32 publications

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“…the eleutherosides similar to ginsenosides that have effects in the body conforming to its definition as an adaptogen [81]. Specifically, six Eleutherococcus compounds exert adaptogenic effects in the body; four of them act as antioxidants, four exhibit anticancer effects, and two show demonstrable immunostimulatory effects [82,83].…”

Section: Siberian Ginseng (Botanical Name: Eleutherococcus Senticosusmentioning

confidence: 96%

“…The immunostimulatory, antiviral, HPA axis-modulatory and fatiguedelaying effects of Siberian ginseng may serve people with CFS to improve these parameters, thereby alleviating some symptomatology of the syndrome. In a placebo-controlled study in humans [81], it showed moderate benefit in CFS. In another study [85], use of a Siberian ginseng containing a formulation called Ciwujia showed on exercise performance under a constant endurance load of 450 kg × m/min (75 W) that the preparation could increase oxygen uptake, spare the glycogen in muscle, and improve the exercise endurance and work performance in humans.…”

Section: Siberian Ginseng (Botanical Name: Eleutherococcus Senticosusmentioning

confidence: 96%

See 1 more Smart Citation

Herbal Drugs in Chronic Fatigue Syndrome: An Overview

Semalty

Panda

et al. 2012

Schweiz Z Ganzheitsmed

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Chronic fatigue syndrome (CFS) is a debilitating and complex disorder characterized by profound fatigue of 6 months or longer duration that is not improved by bed rest and that may be worsened by physical or mental activity. It is often age-related and may coexist with other diseases such as multiple sclerosis, Parkinson’s disease, depression, cancer, HIV infection etc. Persons with CFS most often function at a substantially lower level of activity than they were capable of before the onset of illness. Modern medicine has limited therapies and those offered by it have strong side-effects. On the other hand, various traditional systems of medicine such as the Chinese herbal system and Ayurveda offer several botanicals, especially the adaptogens, which have been used to combat chronic fatigue effectively. Literature reports a plethora of animal and clinical studies on the safety and efficacy of these plant drugs. The present article extensively reviews CFS, its pathophysiology, and its pharmacological treatment, with a special emphasis on herbal drugs such as Cat’s claw, Ginseng, caterpillar fungus, ashwagandha, Tulsi, jiaogulan etc. The botanical therapies discussed here are very commonly used drugs with profound data available on them.

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Section: Siberian Ginseng (Botanical Name: Eleutherococcus Senticosusmentioning

confidence: 96%

Section: Siberian Ginseng (Botanical Name: Eleutherococcus Senticosusmentioning

confidence: 96%

Herbal Drugs in Chronic Fatigue Syndrome: An Overview

Semalty

Panda

et al. 2012

Schweiz Z Ganzheitsmed

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“…Some showed no difference between Ginseng and placebo on relieving fatigue (13). On the other hand, in a randomized controlled trial of Ginseng for chronic fatigue, fatigue severity and duration were significantly improved in response to Ginseng and treatment was effective at 2 months for 45 subjects who had less severe fatigue among the group of 76 patients studied (14). In addition, Ginseng's ability to enhance cognitive performance in CFS patients was proven in a double-blind, placebo-controlled study (15).…”

Section: Present Evidence To Support the Efficacy Of Tcm In Treating mentioning

confidence: 99%

Traditional Chinese Medicine for Chronic Fatigue Syndrome

Chen

Moriya

Yamakawa

et al. 2008

Evidence-Based Complementary and Alternative Medicine

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More and more patients have been diagnosed as having chronic fatigue syndrome (CFS) in recent years. Western drug use for this syndrome is often associated with many side-effects and little clinical benefit. As an alternative medicine, traditional Chinese medicine (TCM) has provided some evidences based upon ancient texts and recent studies, not only to offer clinical benefit but also offer insights into their mechanisms of action. It has perceived advantages such as being natural, effective and safe to ameliorate symptoms of CFS such as fatigue, disordered sleep, cognitive handicaps and other complex complaints, although there are some limitations regarding the diagnostic standards and methodology in related clinical or experimental studies. Modern mechanisms of TCM on CFS mainly focus on adjusting immune dysfunction, regulating abnormal activity in the hypothalamic-pituitary-adrenal (HPA) axis and serving as an antioxidant. It is vitally important for the further development to establish standards for ‘zheng’ of CFS, i.e. the different types of CFS pathogenesis in TCM, to perform randomized and controlled trials of TCM on CFS and to make full use of the latest biological, biochemical, molecular and immunological approaches in the experimental design.

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“…Eleutherococcus senticosus) or Siberian ginseng is a spiny-stemmed shrub belonging to the family Araliaceae. In a placebo-controlled study in humans, it showed moderate benefit in chronic fatigue syndrome (Hartz et al, 2004). Another study, using a formulation containing Siberian ginseng called Ciwujia, on exercise performance showed that under a constant endurance load of 450 kg.m/min (75W), the preparation could increase oxygen uptake, spare the glycogen in muscle and improve the exercise endurance and work performance in humans (Wu et al, 1998).…”

Section: Acanthopanacis Senticosusmentioning

confidence: 99%