Randomized controlled trial of multi‐modular motion‐assisted memory desensitization and reconsolidation (3MDR) for male military veterans with treatment‐resistant post‐traumatic stress disorder

Bisson, Jonathan I.; Deursen, Robert William Martin Van; Hannigan, Ben; Kitchiner, Neil J; Barawi, Kali; Jones, Kate; Pickles, Timothy; Skipper, Jessica; Young, Charles Y.F.; Abbott, Leigh R.; Gelderen, Marieke van; Nijdam, Mirjam J.; Vermetten, Eric

doi:10.1111/acps.13200

Cited by 34 publications

(76 citation statements)

References 26 publications

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“…Additionally, to conduct a 3MDR session, a technical operator and therapists are needed, which increases personnel costs (Vermetten et al, 2013;Van Gelderen et al, 2020). However, there is empirical evidence that 3MDR is a successful treatment for patients who cannot benefit from classic trauma-focused guidelines, which can reduce long-term therapy costs (Bisson et al, 2020;Van Gelderen et al, 2020). Nevertheless, the cost-efficiency aspect of virtual trauma intervention is not satisfactorily answered through research.…”

Section: Trauma Therapy and Virtual Realitymentioning

confidence: 99%

“…We identified a total of 805 articles, of which 18 met the inclusion criteria. Of the 18 studies, nine (50%) (Difede et al, 2013;Rothbaum et al, 2014;Reger et al, 2016;Beidel et al, 2017a;McLay et al, 2017;Maples-Keller et al, 2018;Van't Wout et al, 2018;Bisson et al, 2020;Van Gelderen et al, 2020) were RCTs with a total of 483 patients (317 received VR treatment, 100 received an active treatment and 66 allocated to waitlist). Six (33.3%) (Vermetten et al, 2013;Arens, 2014;Kengne et al, 2018;Menelas et al, 2018;Nijdam and Vermetten, 2018;Van Gelderen et al, 2018) were case studies examined a total of 10 patients and three (16.6%) (Beidel et al, 2017b;Jetly et al, 2017;Loucks et al, 2018) were non-randomized single-arm trials subsumed to pilot studies with a total of 116 patients.…”

Section: General Overviewmentioning

confidence: 99%

“…Ten studies (55.5%) (Difede et al, 2013;Arens, 2014;Rothbaum et al, 2014;Reger et al, 2016;Beidel et al, 2017a,b;McLay et al, 2017;Loucks et al, 2018;Maples-Keller et al, 2018;Van't Wout et al, 2018) were conducted in North America, three (16.6%) (Jetly et al, 2017;Kengne et al, 2018;Menelas et al, 2018) in Canada, four in the Netherlands (22.2%) (Vermetten et al, 2013;Nijdam and Vermetten, 2018;Van Gelderen et al, 2018, 2020 and one in Wales, United Kingdom (5.5%) (Bisson et al, 2020). Patients were predominantly male (92.7%), and the mean age ranged from 29 (Reger et al, 2016) -51 (Nijdam and Vermetten, 2018).…”

Section: General Overviewmentioning

confidence: 99%

“…Regarding the main research question, the results indicate that there are three different approaches to a virtual trauma intervention, namely, VRET (Difede et al, 2013;Arens, 2014;Rothbaum et al, 2014;Reger et al, 2016;Beidel et al, 2017a,b;McLay et al, 2017;Loucks et al, 2018;Maples-Keller et al, 2018;Van't Wout et al, 2018), 3MDR (Vermetten et al, 2013;Jetly et al, 2017;Nijdam and Vermetten, 2018;Van Gelderen et al, 2018, 2020Bisson et al, 2020), and action-centered exposure therapy (ACET) (Kengne et al, 2018;Menelas et al, 2018). The following describes the results of all research questions separated based on the application of VRET, 3MDR, and ACET (see Table 2 for the results of the qualitative analysis for each study and Table 3 for an overview of the results).…”

Section: General Overviewmentioning

confidence: 99%

“…One central part of the preparatory sessions is the selection process of 10-20 highly affective photographs associated with the traumatic experience (Bisson et al, 2020;Van Gelderen et al, 2020). The patients can choose any photograph they want to see (Bisson et al, 2020).…”

Section: Multi-modular Motion-assisted Memory Desensitization and Recmentioning

confidence: 99%

See 4 more Smart Citations

Virtual Trauma Interventions for the Treatment of Post-traumatic Stress Disorders: A Scoping Review

et al. 2020

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Section: Trauma Therapy and Virtual Realitymentioning

confidence: 99%

Section: General Overviewmentioning

confidence: 99%

Section: General Overviewmentioning

confidence: 99%

Section: General Overviewmentioning

confidence: 99%

Section: Multi-modular Motion-assisted Memory Desensitization and Recmentioning

confidence: 99%

See 3 more Smart Citations

Virtual Trauma Interventions for the Treatment of Post-traumatic Stress Disorders: A Scoping Review

et al. 2020

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Quantitative changes in mental health measures with 3MDR treatment for Canadian military members and veterans

et al. 2022

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Objective Military members and veterans are at elevated risk of treatment‐resistant posttraumatic stress disorder (TR‐PTSD) due to higher rates of exposure to potentially traumatic events during the course of duty. Knowledge of TR‐PTSD is limited, and specific protocols or evidence‐based TR‐PTSD therapies are lacking. Multimodal motion‐assisted memory desensitization and reconsolidation (3MDR) therapy is an emerging intervention for combat‐related TR‐PTSD. The purpose of this study was to preliminarily assess the effectiveness of 3MDR in addressing TR‐PTSD in Canadian military members and veterans. Methods This study is a longitudinal mixed‐methods clinical trial. English‐speaking military members and veterans aged 18–60 with TR‐PTSD were recruited to participate. The intervention consisted of six sessions of 3MDR therapy. Quantitative data were collected pretreatment, posttreatment, and longitudinally at 1, 3, and 6 months after completion of 3MDR. Results Results from the first 11 participants to complete the 3MDR protocol exhibited statistically significant improvement (surviving multiple comparison correction) in clinically administered and self‐reported scores for PTSD (CAPS‐5 and PCL‐5), moral injury (MISS‐M‐SF), depression (PHQ‐9), anxiety (GAD‐7), emotional regulation (DERS‐18), and resilience (CD‐RS‐25). Conclusion The preliminary and exploratory results from this clinical trial support the growing body of literature illustrating 3MDR as an effective treatment for military‐related TR‐PTSD. These results are notable given participants' previous lack of success with frontline psychotherapeutic and pharmacological interventions. Given that there are currently very limited treatment options for TR‐PTSD, 3MDR could prove to be a valuable treatment option for military members and veterans with TR‐PTSD.

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The impact of trauma‐focused psychotherapy for posttraumatic stress disorder on interpersonal functioning: A systematic review and meta‐analysis of randomized clinical trials

Swerdlow

Baker

Leifker

et al. 2023

Journal of Traumatic Stress

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Interpersonal functioning is a common concern for people with postttraumatic stress disorder (PTSD) but is not a key target of most trauma‐focused psychotherapies (TFPs). We preregistered and undertook a systematic review and meta‐analysis of randomized clinical trials (RCTs) examining the efficacy of TFPs for improving interpersonal functioning. Studies were identified through the PTSD Trials Standardized Data Repository, scholarly databases, and the solicitation of unpublished data from the PTSD research community following current PRISMA guidelines. We used random effects meta‐analysis to estimate within‐group change (i.e., pre‐ to posttreatment) in interpersonal functioning. Meta‐analytic findings yielded a medium total effect of TFP on interpersonal functioning, g = 0.54, 95% CI [0.37, 0.72], with high between‐study heterogeneity. Sensitivity analyses yielded substantively equivalent point estimates when outliers were excluded, g = 0.55, and when only the most well‐established individual TFPs were included, g = 0.57. In contrast, allocation to a control condition was associated with little average change in interpersonal functioning, g = 0.04 [‐0.12, 0.21]. Formal tests did not yield clear evidence of publication bias. Bias‐corrected estimates varied but centered around a medium effect, gs = 0.41–1.11. There was a medium‐to‐large association between change in interpersonal functioning and change in PTSD symptoms, rs = ‐.35–‐.44. The extant literature on TFPs and interpersonal functioning is small and heterogeneous, indicating the need for more focused attention on this outcome. Results suggest that, on average, TFPs are moderately efficacious for improving interpersonal functioning; however, additional treatment may be needed to meet the desired level of improvement

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Randomized controlled trial of multi‐modular motion‐assisted memory desensitization and reconsolidation (3MDR) for male military veterans with treatment‐resistant post‐traumatic stress disorder

Cited by 34 publications

References 26 publications

Virtual Trauma Interventions for the Treatment of Post-traumatic Stress Disorders: A Scoping Review

Virtual Trauma Interventions for the Treatment of Post-traumatic Stress Disorders: A Scoping Review

Quantitative changes in mental health measures with 3MDR treatment for Canadian military members and veterans

The impact of trauma‐focused psychotherapy for posttraumatic stress disorder on interpersonal functioning: A systematic review and meta‐analysis of randomized clinical trials

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