Randomized Controlled Trial of Moxifloxacin Compared With Piperacillin???Tazobactam and Amoxicillin???Clavulanate for the Treatment of Complicated Intra-abdominal Infections

Malangoni, Mark A.; Song, James; Herrington, Janet; Choudhri, Shurjeel; Pertel, Peter

doi:10.1097/01.sla.0000230024.84190.a8

Cited by 106 publications

(99 citation statements)

References 15 publications

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“…According to previously reported studies and case reports, MXF has been shown to be successful for the treatment of abscesses of other origins, e.g., skin (26) and abdominal cavity (16).…”

Section: Discussionmentioning

confidence: 99%

Comparative Efficacy and Safety of Moxifloxacin and Clindamycin in the Treatment of Odontogenic Abscesses and Inflammatory Infiltrates: a Phase II, Double-Blind, Randomized Trial

Cachovan

Böger

Giersdorf

et al. 2011

Antimicrob Agents Chemother

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“…According to previously reported studies and case reports, MXF has been shown to be successful for the treatment of abscesses of other origins, e.g., skin (26) and abdominal cavity (16).…”

Section: Discussionmentioning

confidence: 99%

Comparative Efficacy and Safety of Moxifloxacin and Clindamycin in the Treatment of Odontogenic Abscesses and Inflammatory Infiltrates: a Phase II, Double-Blind, Randomized Trial

Cachovan

Böger

Giersdorf

et al. 2011

Antimicrob Agents Chemother

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“…Future prospective studies are needed to determine whether antibiotics alone or with percutaneous drainage is a non-inferior treatment to surgical therapy in pregnant patients with appendicitis. Although several different antibiotic regimens have been proposed [142][143][144], the type, duration and indications for these antibiotics are yet to be determined in pregnant patients.…”

Section: Discussionmentioning

confidence: 99%

Review of Operative vs. Non-Operative Management of Appendicitis in Pregnancy

Blears¹,

Keller²,

Ellis³

2017

Surgery Curr Res

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The last decade has marked a paradigm shift in the care for acute appendicitis in children and non-pregnant adults. Although surgical management remains the safest treatment modality for perforated or complicated appendicitis, antibiotic therapy has been proven to be safe in adult and pediatric patients with non-perforated appendicitis. However, controversy exists for the type of surgery (laparoscopic vs. open) and the post-operative antibiotic regimens which result in optimal patient care of pregnant as well as non-pregnant adults. As several authors have begun to evaluate a non-operative strategy for treating acute appendicitis, whether with antibiotic therapy alone or combined with image-guided percutaneous drainage, others have retrospectively analyzed these strategies to pregnant women with abdominal pain. This collective review presents the epidemiology and diagnostic challenges of acute appendicitis in the pregnant patient and a review of the data that supports non-operative management in non-pregnant adults and pediatric patients as well as the limited data that supports non-operative management in pregnant adults.

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“…The best evidence for the efficacy of an oral regimen comes from the study of Solomkin et al [53], in which a switch to the use of oral ciprofloxacin ϩ metronidazole was found to be as effective as continued intravenous therapy in the treatment of patients with complicated intraabdominal infections. In other trials for complicated intraabdominal infections, oral moxifloxacin was used as continuation therapy after intravenous moxifloxacin [56], and amoxicillin/clavulanic acid was used as continuation therapy after piperacillin/tazobactam or a carbapenem [33]. No prospective studies have investigated the use of oral antibiotics specifically for the treatment of diverticulitis.…”

Section: Oral Antimicrobial Therapymentioning

confidence: 99%

“…Moxifloxacin was evaluated recently for complicated intra-abdominal infections in a randomized controlled trial [56]. Intravenous moxifloxacin with an option for oral conversion was compared with piperacillin/tazobactam, with the option of conversion to oral amoxicillin/clavulanic acid.…”

Section: Fluoroquinolonesmentioning

confidence: 99%

Antimicrobial Therapy for Acute Colonic Diverticulitis

Byrnes

Mazuski

2009

Surgical Infections

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Background: Although guidelines and reviews have systematically evaluated diagnosis and surgical management of acute diverticulitis, they have focused only minimally on antibiotic selection for the treatment of this disease. We undertook a review of the literature to assess more clearly the use of specific antimicrobial agents in the treatment of patients with acute diverticulitis of the colon. Methods: A MEDLINE search was conducted to identify original research, review papers, and guidelines on the use of antimicrobial agents for the treatment of acute diverticulitis. Results:The general recommendation to use antibiotics with activity against common gram-negative and anaerobic pathogens has remained consistent. A number of single agents and combination regimens provide such activity. However, there is little evidence on which to base selection of specific antimicrobial regimens, and no regimen has demonstrated superiority. In general, episodes of diverticulitis severe enough to warrant hospitalization should be managed initially with intravenous antibiotics. Oral therapy can be used for outpatient treatment or when the patient's condition improves. There is a paucity of data regarding the optimal duration of antimicrobial therapy. Conclusions: Careful clinical studies are needed to evaluate better the antibiotic regimens for the treatment of acute diverticulitis. Until such studies are conducted, we are forced to rely on tradition, in vitro analyses, pharmacokinetic profiling, and indirect evidence from studies of complicated intra-abdominal infections to determine appropriate therapy for this disease.

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Randomized Controlled Trial of Moxifloxacin Compared With Piperacillin???Tazobactam and Amoxicillin???Clavulanate for the Treatment of Complicated Intra-abdominal Infections

Abstract: Once daily IV/PO moxifloxacin monotherapy was as least as effective as standard IV piperacillin-tazobactam/PO amoxicillin-clavulanate dosed multiple times daily for the treatment of cIAIs.

Cited by 106 publications

References 15 publications

Comparative Efficacy and Safety of Moxifloxacin and Clindamycin in the Treatment of Odontogenic Abscesses and Inflammatory Infiltrates: a Phase II, Double-Blind, Randomized Trial

Comparative Efficacy and Safety of Moxifloxacin and Clindamycin in the Treatment of Odontogenic Abscesses and Inflammatory Infiltrates: a Phase II, Double-Blind, Randomized Trial

Review of Operative vs. Non-Operative Management of Appendicitis in Pregnancy

Antimicrobial Therapy for Acute Colonic Diverticulitis

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