Randomized Controlled Trial of Intramuscular Droperidol Versus Midazolam for Violence and Acute Behavioral Disturbance: The DORM Study

Isbister, Geoffrey K.; Calver, Leonie; Page, Colin B.; Stokes, Barrie; Bryant, Jenni L; Downes, Michael A.

doi:10.1016/j.annemergmed.2010.05.037

Cited by 130 publications

(168 citation statements)

References 23 publications

Supporting

Mentioning

153

Contrasting

Unclassified

Order By: Relevance

“…In particular, FGAs are known to cause both cardiac-related side effects and movement-related side effects such as tardive dyskinesia or dystonia (8,9,(17)(18)(19). Given the black box warning by the U.S. Food and Drug Administration (FDA) issued in 2001, the safety profile of droperidol remains a controversial topic in ED literature, with several studies suggesting its safety in everyday clinical use (19)(20)(21)(22)(23)(24)(25). Although haloperidol has not received a black-box warning from the FDA, the risk of motorrelated side effects is quite common in practice.…”

Section: Introductionmentioning

confidence: 99%

First-generation Antipsychotics Are Often Prescribed in the Emergency Department but Are Often Not Administered with Adjunctive Medications

Campillo¹,

Castillo

Vilke

et al. 2015

The Journal of Emergency Medicine

View full text Add to dashboard Cite

, Abstract-Background: Although first-generation antipsychotics (FGAs) have long been used in the emergency department (ED) to treat acute agitation, little is known about how these medications are used in modern clinical practice. In particular, little work has been published about whether ED clinicians administer FGAs with adjunctive medications in accordance with expert guidelines or the prescribing practices of FGAs over time. Objectives: 1) To provide a comparison of the frequency with which FGAs are administered with adjunctive benzodiazepines or anticholinergic medications. 2) To analyze the prescribing trends for FGAs over time, particularly in the years after the U.S. Food and Drug Administration (FDA) black-box warning for droperidol. Methods: This is a structured review of a retrospective cohort of patients receiving haloperidol or droperidol in two EDs over a 7-year period. Results: Haloperidol or droperidol was administered on 2833 patient visits during the study period, with haloperidol being administered most often. Adjunctive medications are administered less than half of the time. The use of droperidol has remained relatively static, whereas the use of haloperidol has increased. Conclusions: First-generation antipsychotics are still widely utilized in the ED. When administered, these medications are used with adjunctive medications that may decrease side effects less than half of the time. Droperidol use has remained unchanged in the years after the FDA black-box warning, whereas use of haloperidol has continued to rise. Ó 2015 Elsevier Inc.

show abstract

Section: Introductionmentioning

confidence: 99%

First-generation Antipsychotics Are Often Prescribed in the Emergency Department but Are Often Not Administered with Adjunctive Medications

Campillo¹,

Castillo

Vilke

et al. 2015

The Journal of Emergency Medicine

View full text Add to dashboard Cite

show abstract

“…In such cases, patients should be always monitored for QT prolongation. [26,27] In the second case of our series, we added low doses of quetiapine to the patient's treatment (benzodiazepines), which proved to be more effective in the management of his psychiatric manifestations.…”

Section: Discussionmentioning

confidence: 99%

Anticholinergic syndrome induced by toxic plants

Σουλαϊδόπουλος

Sinakos

Dimopoulou

et al. 2017

World Journal of Emergency Medicine

View full text Add to dashboard Cite

“…[15][16][17] Two of the three studies were superiority trials, 15,17 while one was a non-inferiority trial. 16 Two RCTs involved a single study centre.…”

Section: Methodsmentioning

confidence: 99%

“…16 Two RCTs involved a single study centre. 15,17 One evidence-based CPG, published by the National Institute for Health and Care Excellence (NICE) in 2015, provided recommendations on the short-term management of violence and aggression in mental health, health and community settings. 21 Part of the recommendations included use of rapid tranquilization.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Agitation: Where We’re Going, Where We’ve Been

Zeller¹

2017

The Diagnosis and Management of Agitation

View full text Add to dashboard Cite

Disclaimer: The Rapid Response Service is an information service for those involved in planning and providing health care in Canada. Rapid responses are based on a limited literature search and are not comprehensive, systematic review s. The intent is to provide a list of sources of the best evidence on the topic that CADTH could identify using all reasonable efforts w ithin the time allow ed. Rapid responses should be considered along w ith other types of information and health care considerations. The information included in this response is not intended to replace professional medical advice, nor should it be construed as a recommendation for or against the use of a particular health technology. Readers are also cautioned that a lack of good quality evidence does not necessarily mean a lack of effectiveness particularly in the case of new and emerging health technologies, for w hich little information can be found, but w hich may in future prove to be effective. While CADTH has taken care in the preparation of the report to ensure that its contents are accurate, complete and up to date, CADTH does not make any guarantee to that ef fect. CADTH is not liable for any loss or damages resulting from use of the information in the report.Copyright: This report contains CADTH copyright material and may contain material in w hich a third party ow ns copyright. This report m ay be used for the purposes of rese arch or private study only. It may not be copied, posted on a w eb site, redistributed by email or stored on an electronic system w ithout the prior w ritten permission of CADTH or applicable copyrigh t ow ner.Links: This report may contain links to other information available on the w ebsites of third parties on the Internet. CADTH does not have control over the content of such sites. Use of thi rd party sites is governed by the owners" own terms and conditions .

show abstract

Randomized Controlled Trial of Intramuscular Droperidol Versus Midazolam for Violence and Acute Behavioral Disturbance: The DORM Study

Cited by 130 publications

References 23 publications

First-generation Antipsychotics Are Often Prescribed in the Emergency Department but Are Often Not Administered with Adjunctive Medications

First-generation Antipsychotics Are Often Prescribed in the Emergency Department but Are Often Not Administered with Adjunctive Medications

Anticholinergic syndrome induced by toxic plants

Agitation: Where We’re Going, Where We’ve Been

Contact Info

Product

Resources

About