Randomized Controlled Trial of Interventions for Young People at Ultra High Risk for Psychosis

Yung, Alison R.; Phillips, Lisa; Nelson, Barnaby; Francey, Shona; PanYuen, Hok; Simmons, Magenta; Ross, Margaret; Kelly, Daniel P.; Baker, Kathryn; Amminger, G. Paul; Berger, Gregor; Thompson, Andrew; Thampi, Annette; McGorry, Patrick D.

doi:10.4088/jcp.08m04979ora

Cited by 133 publications

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“…Indeed, it has been postulated that at times psychotic-like symptoms may represent 'clinical noise' around a non-psychotic syndrome [55]. Regardless of this the high levels of distress and impairments our participants reported suggest that these individuals require some form of support from services.…”

Section: Discussionmentioning

confidence: 66%

The ‘At-Risk Mental State’ for Psychosis in Adolescents: Clinical Presentation, Transition and Remission

Welsh

Tiffin

2013

Child Psychiatry Hum Dev

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. (2014) 'The 'At-risk mental state' for psychosis in adolescents : clinical presentation, transition and remission.', Child psychiatry and human development., 45 (1). pp. 90-98.Further information on publisher's website:http://dx.doi.org/10.1007/s10578-013-0380-z Publisher's copyright statement:The nal publication is available at Springer via http://dx.doi.org/10.1007/s10578-013-0380-z.Additional information: Use policyThe full-text may be used and/or reproduced, and given to third parties in any format or medium, without prior permission or charge, for personal research or study, educational, or not-for-pro t purposes provided that:• a full bibliographic reference is made to the original source • a link is made to the metadata record in DRO • the full-text is not changed in any way The full-text must not be sold in any format or medium without the formal permission of the copyright holders.Please consult the full DRO policy for further details. 2 Abstract:Despite increased efforts over the last decade to prospectively identify individuals at ultrahigh risk of developing a psychotic illness, limited attention has been specifically directed towards adolescent populations (<18 years). In order to evaluate how those under 18 fulfilling the operationalised criteria for an At-Risk Mental State (ARMS) present and fare over time, we conducted an observational study. Participants (N=30) generally reported a high degree of functional disability and frequent and distressing perceptual disturbance, mainly in the form of auditory hallucinations. Seventy percent (21/30) were found to fulfil the criteria for a co-morbid ICD-10 listed mental health disorder, with mood (affective; 13/30) disorders being most prevalent. Overall transition rates to psychosis were low at 24 month follow-up (2/28; 7.1%) whilst many participants demonstrated a significant reduction in psychotic-like symptoms. The generalisation of these findings may be limited due to the small sample size and require replication in a larger sample.

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Section: Discussionmentioning

confidence: 66%

The ‘At-Risk Mental State’ for Psychosis in Adolescents: Clinical Presentation, Transition and Remission

Welsh

Tiffin

2013

Child Psychiatry Hum Dev

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“…Seven studies -three intervention (Berger et al, 2012;McGorry et al, 2002;Yung et al, 2011) and four cohort (Phillips et al, 2009;Thompson et al, 2007;Yung et al, 1996;Yung et al, 2003) studies -were conducted over this period.…”

Section: Setting and Samplementioning

confidence: 99%

Further examination of the reducing transition rate in ultra high risk for psychosis samples: The possible role of earlier intervention

Nelson

Yuen

Lin

et al. 2016

Schizophrenia Research

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“…Murphy & Brewer (2011a) fail to distinguish between individuals in the prodrome and individuals at ultra-high risk of psychosis: this is a key conceptual problem for the field. They also fail to report that the rate of conversion to psychosis in recent studies of high-risk populations is very low and that work from EPPIC itself (Yung 2011) showed 6-month conversion rates of between 5.1% and 7.0%. The EPPIC study also failed to show any difference in primary or secondary out comes between cognitive therapy plus risperidone, cognitive therapy plus placebo, supportive therapy and simply monitoring.…”

Section: Propping Up the Paradigmmentioning

confidence: 91%

Should early psychosis intervention be the focus for mental health services?

Castle¹

2011

Adv. psychiatr. treat

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Randomized Controlled Trial of Interventions for Young People at Ultra High Risk for Psychosis

Abstract: http://www.anzctr.org.au Identifier: ACTRN012605000247673.

Cited by 133 publications

References 0 publications

The ‘At-Risk Mental State’ for Psychosis in Adolescents: Clinical Presentation, Transition and Remission

The ‘At-Risk Mental State’ for Psychosis in Adolescents: Clinical Presentation, Transition and Remission

Further examination of the reducing transition rate in ultra high risk for psychosis samples: The possible role of earlier intervention

Should early psychosis intervention be the focus for mental health services?

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