Randomized Controlled Trial of Early Parenteral Nutrition Cycling to Prevent Cholestasis in Very Low Birth Weight Infants

Retrospective Dual‐Center Study of Parenteral Nutrition–Associated Cholestasis in Premature Neonates: 15 Years' Experience

“…The idea of sex differences in PNAC has not yet reached a consensus among researchers. For instance, Albers et al 22 showed that male sex may predispose neonate surgical patients to PNAC, and similar results were reported by Jolin‐Dahel et al 2 However, male sex is not identified as a risk factor in many other studies 3 , 8 , 10 , 30 …”

Parenteral Nutrition-Associated Liver Disease in Pediatric Patients: Strategies for Treatment and Prevention

“…At any time during the course of PN, after adjusting for other confounding factors, patients who received continuous PN were 2.86 times more likely to develop hyperbilirubinemia as compared to those patients on cycled PN; however, this result was not statistically significant. Conversely, in another study of cyclic PN in very-low-birth-weight infants (weight ≤1,250 g), early cycling of PN did not significantly reduce the development of cholestasis [ 57 ]. Rather, other factors such as duration of PN as well as the time to full enteral feedings were identifi ed as independent risk factors for the development of PNALD.…”

Prácticas de prescripción de nutrición parenteral neonatal en Portugal

“…En casi todas las unidades portuguesas, los lípidos intravenosos se inician en los 3 primeros días posnatales, generalmente en la dosis diaria de 1 g/kg y se aumentan hasta 3 g/kg, como se recomienda 6,15,19 ; en una de las unidades no se prescriben lípidos intravenosos. En todas las unidades se administra la emulsión lipídica a lo largo de las 24 h, excepto en una en que se infunde en 20 h. Esta opción puede basarse en la posible reducción de la incidencia de colestasis asociada a la NP cuando se administra de forma cíclica 20 . La mayoría de las unidades británicas e irlandesas inicia lípidos en el primer día a una dosis inferior (0,1-1 g/kg).…”