Randomized Controlled Trial of Bovine Lactoferrin for Prevention of Sepsis and Neurodevelopment Impairment in Infants Weighing Less Than 2000 Grams

Ochoa, Theresa J.; Zegarra, Jaime; Bellomo, Sicilia; Cárcamo, César; Cam, Luis; Castañeda, Anne; Villavicencio, Aasith; Gonzales, Jorge; Rueda, Maria S; Turin, Christie G.; Zea-Vera, Alonso; Guillén, Daniel; Campos, Miguel; Ewing‐Cobbs, Linda

doi:10.1016/j.jpeds.2019.12.038

Cited by 40 publications

(16 citation statements)

References 40 publications

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“…According to Ochoa et al (17) , sepsis-associated death occurred in 22 infants (10.5%) in the bovine lactoferrin group vs 30 (14.6%) in the placebo group; there was no difference after adjusting for hospital and birth weight; hazard ratio was 0.73 (95% CI, 0.42-1.26). For infants with birth weights of <1500 g the hazard ratio was 0.69 (95% CI, 0.39-1.25).…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Lactoferrin in Prevention of Premature Rupture of Membrane

Fathi

Ali

Mohammed

2021

The Egyptian Journal of Hospital Medicine

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Background: Prematurity is a leading cause of maternal and neonatal mortality and morbidity, complicating up to 10% of all pregnancies. Mortality and morbidities, including respiratory distress syndrome (RDS), intraventricular hemorrhage (IVH), necrotizing enterocolitis (NEC) and sepsis, are inversely associated with gestational age at birth. Objective: This study aimed to decrease the morbidities and mortalities resulting from premature rupture of membrane (PROM).

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Section: Discussionmentioning

confidence: 99%

Efficacy of Lactoferrin in Prevention of Premature Rupture of Membrane

Fathi

Ali

Mohammed

2021

The Egyptian Journal of Hospital Medicine

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“…This is a secondary analysis of the data from the NEOLACTO trial (NCT 01525316) [17]. Briefly, this was a randomized, double-blind, placebo-controlled study to evaluate the effect of oral supplementation of bovine LF in 414 newborns enrolled in the first 3 days of life in Lima.…”

Section: Methodsmentioning

confidence: 99%

“…Our research group has recently conducted a randomized trial to evaluate the effect of daily supplementation of bovine LF on the prevention of neonatal late-onset sepsis (LOS) in < 2,000 g newborns. The study failed to demonstrate a significant effect on the reduction of sepsis [17]. As part of the trial, we obtained breastmilk samples to measure human LF concentrations [18].…”

Section: Introductionmentioning

confidence: 99%

Is Mother’s Own Milk Lactoferrin Intake Associated with Reduced Neonatal Sepsis, Necrotizing Enterocolitis, and Death?

et al. 2020

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Introduction: Lactoferrin (LF) is a protective protein present in milk with anti-infective and immune-modulating properties. Objectives: The aim of this study was to determine the association of maternal LF intake and mother's own milk intake in the first 10 days of life on the prevention of late-onset sepsis (LOS), necrotizing enterocolitis (NEC), or death in the first 8 weeks of life in newborns with a birth weight < 2,000 g. Methods: A retrospective cohort study was conducted, with the exposure being the consumption of mother's own LF and mother's own milk in the first 10 days of life, and the outcome being LOS, NEC, or death during days 11 and 56 of life, analyzed by Cox regression. Results: Two hundred and ninety-nine infants were enrolled, including 240 with human LF intake information. The average daily human LF intake over days 4-10 of life was 283 mg/kg/day (IQR 114-606 mg/ kg/day). The hazard ratio (HR) of mother's own milk LF intake ≥100 mg/kg/day in days 4-10 for LOS, NEC, or death was 0.297 (95% CI 0.156-0.568, p < 0.001); the adjusted HR was 0.752 (95% CI 0.301-1.877, p = 0.541). The adjusted HR of mother's own milk cumulative intake (days 4-10) of 54-344 mL/kg (25-75 quartiles) for LOS, NEC, or death was 0.414 (95% CI 0.196-0.873, p = 0.02). Infants who developed an event (LOS, NEC, or death) had significantly less median daily human LF intake than those that did not (89 vs. 334 mg/ kg/day, respectively, p < 0.0001). Conclusion: Consumption of higher amounts of mother's own milk in the first days of life is associated with less infection, NEC, and death. Early human milk intake should be strongly encouraged in all newborns.

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“…Lf has been studied as an ingredient for the very low birth weight infant with early evidence suggesting some protection against NEC and sepsis [ 99 , 100 ]. A more recent randomized controlled trial (RCT) in the same population did not demonstrate these benefits [ 101 , 102 ]. It is possible that a lack of significant effects on Lf in those infants was related to substantial levels of Lf received by the control group, which was fed HM.…”

Section: Ingredients Inspired By Human Milkmentioning

confidence: 99%

In the Age of Viral Pandemic, Can Ingredients Inspired by Human Milk and Infant Nutrition Be Repurposed to Support the Immune System?

et al. 2021

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In 2020, with the advent of a pandemic touching all aspects of global life, there is a renewed interest in nutrition solutions to support the immune system. Infants are vulnerable to infection and breastfeeding has been demonstrated to provide protection. As such, human milk is a great model for sources of functional nutrition ingredients, which may play direct roles in protection against viral diseases. This review aims to summarize the literature around human milk (lactoferrin, milk fat globule membrane, osteopontin, glycerol monolaurate and human milk oligosaccharides) and infant nutrition (polyunsaturated fatty acids, probiotics and postbiotics) inspired ingredients for support against viral infections and the immune system more broadly. We believe that the application of these ingredients can span across all life stages and thus apply to both pediatric and adult nutrition. We highlight the opportunities for further research in this field to help provide tangible nutrition solutions to support one’s immune system and fight against infections.

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Randomized Controlled Trial of Bovine Lactoferrin for Prevention of Sepsis and Neurodevelopment Impairment in Infants Weighing Less Than 2000 Grams

Cited by 40 publications

References 40 publications

Efficacy of Lactoferrin in Prevention of Premature Rupture of Membrane

Efficacy of Lactoferrin in Prevention of Premature Rupture of Membrane

Is Mother’s Own Milk Lactoferrin Intake Associated with Reduced Neonatal Sepsis, Necrotizing Enterocolitis, and Death?

In the Age of Viral Pandemic, Can Ingredients Inspired by Human Milk and Infant Nutrition Be Repurposed to Support the Immune System?

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