Randomized controlled trial of a synthetic sealant for preventing alveolar air leaks after lobectomy

Adhesive, Flexible, and Robust Polysaccharide Nanosheets Integrated for Tissue‐Defect Repair

“…Therefore, the tight and firm repair of a pleural injury/ defect is really important to prevent air leakage. [12,13] Nevertheless, it is sometimes difficult to practically suture or plicate a large defect or fragile tissue of the emphysematous lung. Overlapping is therefore considered to be an ideal maneuver to repair a pleural defect because it simply seals the injured surface without reducing the tissue volume of the injured lung.…”

The effect of fibrin sealant spraying on prolonged air leak after pulmonary resections: a single center experience

“…Nearly all of these studies represent a heterogeneous group of trials with a variety of products [16][17][18]. An overall review of these trials concluded that systematic use of these products were not recommended, as only one trial demonstrated a reduction in the duration or incidence of prolonged air leak [13].…”

Surgical Management of Prolonged Air Leak in Patients with Underlying Emphysema

“…Pulmonary sealants have been the focus of a large amount of research in the area of intraoperative prevention air leaks, with over a dozen studies on various types of sealants including fibrin glue(59-62), PEG-based sealants (63)(64)(65)(66)(67)(68)(69)(70) and coated collagen patches (71)(72)(73). However, as with studies on other strategies, these papers have generally not focused on patients with emphysema, and individually these studies each have small cohort sizes with very mixed patient populations as well as varying methods for reporting efficacy.…”

“…Thus, the use of sealants should best be reserved for patients at highest risk for developing post-operative prolonged air leak(35, 38), especially since rare complications, particularly empyema (63,67,75) may arise from the use of pulmonary sealants. Indeed, the studies which have focused on patients with emphysema have more consistently shown a significant reduction in the incidence of post-operative prolonged air leak and length of stay (62,73 Table 6.…”