Randomized Controlled Trial of a Novel Device for Tinnitus Sound Therapy During Sleep

Theodoroff, Sarah M.; McMillan, Garnett P.; Zaugg, Tara L.; Cheslock, Megan; Roberts, Chan; Henry, James A.

doi:10.1044/2017_aja-17-0022

Cited by 29 publications

(14 citation statements)

References 29 publications

(18 reference statements)

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“… 19 There is currently no standardized tinnitus evaluation method, but it can be seen from different evaluation methods (numeric rating scales of tinnitus loudness, THI, and the number of subjects with complete residual inhibition) that the effect of tinnitus pitch-matched therapy is better than non-customized noise stimulation. 21 , 23 In an RCT using 1 month of pitch-matched stimulus on tinnitus patients, the compensation for the frequency of hearing loss was not beneficial in suppressing tinnitus, whereas excessive compensation worsened tinnitus both clinically and electrophysiologically. 22 It remains unclear why the efficacy of tinnitus pitch-matched therapy is inconsistent in different studies, and factors such as the etiology of the tinnitus, the intensity of the stimulating sound, adaptation to the stimulating sound, understanding of tinnitus, and treatment duration might all have an effect on the efficacy of tinnitus pitch-matched therapy.…”

Section: Tinnitus Pitch-matched Therapymentioning

confidence: 99%

The state of the art of sound therapy for subjective tinnitus in adults

Wang

Tang

et al. 2020

Therapeutic Advances in Chronic Disease

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Background: Sound therapy is a clinically common method of tinnitus management. Various forms of sound therapy have been developed, but there are controversies regarding the selection criteria and the efficacy of different forms of sound therapy in the clinic. Our goal was to review the types and forms of sound therapy and our understanding of how the different characteristics of tinnitus patients influence their curative effects so as to provide a reference for personalized choice of tinnitus sound therapy. Method: Using an established methodological framework, a search of six databases including PubMed identified 43 records that met our inclusion criteria. The search strategy used the following key words: tinnitus AND (acoustic OR sound OR music) AND (treatment OR therapy OR management OR intervention OR measure). Results: There are various forms of sound therapy, and most of them show positive therapeutic effects. The effect of customized sound therapy is generally better than that of non-customized sound therapy, and patients with more severe initial tinnitus respond better to sound therapy. Conclusion: Sound therapy can effectively suppress tinnitus, at least in some patients. However, there is a lack of randomized controlled trials to identify effective management strategies. Further studies are needed to identify the most effective form of sound therapy for individualized therapy, and large, multicenter, long-term follow-up studies are still needed in order to develop more effective and targeted sound-therapy protocols. In addition, it is necessary to analyze the characteristics of individual tinnitus patients and to unify the assessment criteria of tinnitus.

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Section: Tinnitus Pitch-matched Therapymentioning

confidence: 99%

The state of the art of sound therapy for subjective tinnitus in adults

Wang

Tang

et al. 2020

Therapeutic Advances in Chronic Disease

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“…Our results of this pilot study add to the growing literature that CBT and sound therapy can be helpful for suppressing tinnitus symptoms and their effect on quality of life. 17,18,23,[37][38][39] Following this proof-of-concept pilot study, we will be evaluating the second version of this smartphone program in a large randomized controlled clinical trial.…”

Section: Discussionmentioning

confidence: 99%

Adapting Personal Therapies Using a Mobile Application for Tinnitus Rehabilitation: A Preliminary Study

Abouzari

Goshtasbi

Sarna

et al. 2020

Ann Otol Rhinol Laryngol

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Objectives: To develop a smartphone application providing sound therapy and cognitive behavioral therapy (CBT) for treating tinnitus and performing a proof-of-concept pilot study evaluating its potential efficacy. Methods: An interactive smartphone application available on iOS and Android platforms was developed, which provided an 8-week tinnitus-specific CBT and personalized and frequency-matched sound therapy. Included patients presented to our tertiary clinic between 2017 and 2018, while those waitlisted were regarded as controls. Three surveys were administrated: Tinnitus Handicap Inventory (THI), Generalized Anxiety Disorder 7-item (GAD-7), and Perceived Stress Scale (PSS). Results: A total of 30 patients enrolled in this study consisting of 20 treatment and 10 control patients and mean age was 55.4 ± 11.6 years. Treatment and control patients had similar age, sex, and pre-enrolment GAD and PSS (all P > .05). Baseline THI scores were also similar between treatment and control cohorts (50.1 ± 21.9 vs 62.0 ± 20.7; P = .15). After 8 weeks, though changes in GAD and PSS scores were similar ( P > .05), the treatment group reported a significantly greater improvement in THI scores (17.7 ± 15.8 vs 5.3 ± 10.5, P = .04). Conclusions: This pilot study demonstrated potentially promising efficacy of a smartphone-based CBT and sound therapy platform for treating tinnitus and encourages future randomized controlled trials on this treatment modality.

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“…Various sound therapies with or without music have been used in the management of perceptions of and reactions to tinnitus signal [13]. Music positively affects both neural and hormonal activities and provides psychological relaxation through activation of the limbic or paralimbic systems [14-16].…”

Section: Discussionmentioning

confidence: 99%

“…Listening to music can decrease the level of discomfort caused by tinnitus and personal music players can be used for this purpose [17, 18]. It was also proposed that music therapy applied during sleep is even effective in tinnitus treatment [13].…”

Section: Discussionmentioning

confidence: 99%

Individualized Treatment of Tinnitus during Sleep Using Combined Tinnitus Signal and Music

Deni̇z

Bayazıt

Sarac

2020

ORL

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Introduction: Tinnitus is a widely seen otological symptom that interferes with daily activities and causes discomfort. Tinnitus treatments can be classified into 4 main groups: pharmacological treatments, cognitive and behavioral therapy, psychological treatments, and combined treatment approaches made up of at least 2 of these 3 treatment methods. Objective: The aim of this study was to assess whether it would be possible to develop an individualized treatment method of tinnitus by application of a combined tinnitus signal and music during sleep. Methods: Forty-three ears of 30 patients who had subjective tinnitus were included. The patients were evaluated using Tinnitus Handicap Inventory, Visual Analogue Scale, and Beck Depression Inventory. The psychoacoustic parameters of tinnitus, such as tinnitus frequency and loudness, and minimal masking levels, were determined. The patients were asked to select musical melodies that they liked. The tinnitus frequency of each patient was taken as the central frequency according to ANSI 2004. All sound files were prepared as stereo channels, with 16-bit resolution and 44,100 Hz sampling rate. The root mean square power value of the music and the band noise’s average root mean square power value were equalized with the “Amplification” command, and 70% of the music and 30% of wide/narrow-band noise were mixed as a stereo channel by the “Mix Paste” command. The patients were instructed to listen to that individualized music/narrow-band noise (tinnitus signal) for 2 h during sleep for a duration of 6 months. Results: Tinnitus frequencies of the patients measured prior to treatment and at the second, fourth, and sixth months of follow-up were not significantly different. A statistically significant decrease was seen in tinnitus loudness, minimal masking levels, and residual inhibition during the follow-up. Tinnitus Handicap Inventory scores decreased significantly during follow-up, and the number of patients who complained of tinnitus decreased (p < 0.05). The Visual Analogue Scale scores significantly decreased during follow-up (p < 0.05). Beck Depression Inventory scores decreased significantly during follow-up (p < 0.05). Conclusion: Stimulation of the auditory and limbic systems during sleep by the tinnitus signal combined with individualized musical melodies seems an alternative, effective, and cheap method in the treatment of tinnitus.

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Randomized Controlled Trial of a Novel Device for Tinnitus Sound Therapy During Sleep

Abstract: https://doi.org/10.23641/asha.5545759.

Cited by 29 publications

References 29 publications

The state of the art of sound therapy for subjective tinnitus in adults

The state of the art of sound therapy for subjective tinnitus in adults

Adapting Personal Therapies Using a Mobile Application for Tinnitus Rehabilitation: A Preliminary Study

Individualized Treatment of Tinnitus during Sleep Using Combined Tinnitus Signal and Music

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