Randomized Controlled Trial of a Structured Training Program in Breast Cancer Patients with Tumor-Related Chronic Fatigue

Heim, Manfred; Malsburg, Marie-Luise Elsner v. d.; Niklas, Andree

doi:10.1159/000104097

Cited by 52 publications

(77 citation statements)

References 16 publications

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“…Our results are similar to previous studies and meta-analysis [8,36,[51][52][53][54][55][56]. However, this is a post-treatment study, which may lead to greater changes than previous studies developed during chemotherapy [57], suggesting that the best opportunity to modify PROs should be after cancer (neo) adjuvant treatments.…”

supporting

confidence: 87%

“…It is estimated that around 60 % of patients present one upper-body symptom, which affects breast cancer patients' daily activities and reduces significantly their quality of life [31]. Others have previously shown similar results to ours [34][35][36][37][38][39][40], despite the fact that most of these studies involved longer interventions. We are encouraged that shorter interventions of even 12 weeks appear effective to reduce such treatment side effects achieving similar improvements.…”

Section: Discussionsupporting

confidence: 64%

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Supervised physical exercise improves VO2max, quality of life, and health in early stage breast cancer patients: a randomized controlled trial

Casla

López-Tarruella

Jerez

et al. 2015

Breast Cancer Res Treat

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Breast cancer patients suffer impairment in cardiorespiratory fitness after treatment for primary disease, affecting patients' health and survival. The aim of this study was to evaluate the ability of a pragmatic exercise intervention to improve cardiorespiratory fitness of breast cancer patients after primary treatment. Between February 2013 and December 2014, 94 women with early stage (I-III) breast cancer, 1-36 months post-chemotherapy, and radiotherapy were randomly assigned to an intervention program (EX) combining supervised aerobic and resistance exercise (n = 44) or usual care (CON) (n = 45) for 12 weeks. Primary study endpoint was VO 2max . Secondary endpoints were muscle strength, shoulder range of motion, body composition, and quality of life (QoL). Assessments were undertaken at baseline, 12-week, and 6-month followups. Eighty-nine patients aged 29-69 years were assessed at baseline and 12 weeks. The EX group showed significant improvements in VO 2max , muscle strength, percent fat, and lean mass (p B 0.001 in all cases) and QoL compared with usual care (CON). Apart from body composition, improvements were maintained for the EX at 6-month follow-up. There were no adverse events during the testing or exercise intervention program. A combined exercise intervention produced considerable improvement in cardiorespiratory fitness, physical function, and quality of life in breast cancer patients previously treated with chemotherapy and radiation therapy. Importantly, most of these benefits were maintained 6 months after ceasing the supervised exercise intervention.

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supporting

confidence: 87%

Section: Discussionsupporting

confidence: 64%

Supervised physical exercise improves VO2max, quality of life, and health in early stage breast cancer patients: a randomized controlled trial

Casla

López-Tarruella

Jerez

et al. 2015

Breast Cancer Res Treat

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“…Twenty-five studies examined exercise interventions exclusively in breast cancer survivors (44)(45)(46)(47)(48)(49)(50)(51)(52)(53)(54)(55)(57)(58)(59)(60)(61)(62)(63)(64)(65)(66)(67)(68), 4 in prostate cancer survivors (69-72), 4 in lymphoma (73-76), 1 in leukemia (78), and 1 in colorectal cancer (77). The remaining 9 studies examined exercise interventions in a mixed group of cancer survivors (35)(36)(37)(38)(39)(40)(41)(42)(43) Table 5 characteristics of included studies, Supplementary).…”

Section: Resultsmentioning

confidence: 99%

Efficacy of Exercise Interventions in Modulating Cancer-Related Fatigue among Adult Cancer Survivors: A Meta-Analysis

Brown

Huedo‐Medina²,

Pescatello³

et al. 2011

Cancer Epidemiology, Biomarkers &Amp; Prevention

359

269

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Background: The purpose of this meta-analysis was to explore the efficacy of exercise as a nonpharmacologic intervention to reduce cancer-related fatigue (CRF) among adult cancer survivors. We also investigated how different components of the exercise prescription (Ex R x ), methodologic considerations, and subject characteristics modulate CRF.Methods: A systematic search for randomized controlled trials was conducted using words related to cancer, exercise, and fatigue.Results: In total, 44 studies with 48 interventions qualified, including 3,254 participants of varying cancer types, stages of diagnosis, treatments, and exercise interventions. Cancer survivors in exercise interventions reduced their CRF levels to a greater extent than usual care controls, d þ ¼ 0.31 (95% CI ¼ 0.22-0.40), an effect that appeared to generalize across several types of cancer. CRF levels improved in direct proportion to the intensity of resistance exercise (b ¼ 0.60, P ¼ 0.01), a pattern that was stronger in higher quality studies (b ¼ 0.23, P < 0.05). CRF levels also reduced to a greater extent when interventions were theoretically driven (b ¼ 0.48, P < 0.001) or cancer survivors were older (b ¼ 0.24, P ¼ 0.04).Conclusions: Exercise reduced CRF especially in programs that involved moderate-intensity, resistance exercise among older cancer survivors and that were guided by theory.Impact: Our results indicate exercise interventions for adult cancer survivors should be multi-dimensional and individualized according to health outcome and cancer type. Cancer Epidemiol Biomarkers Prev; 20(1); 123-33.

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“…Detailed assessment of the full text of the 39 remaining trials resulted in the exclusion of a further34trials.Ofthese,24trialswereconductedinanout-patientsetting,12werenon-controlledtrials,3hadnoexer-ciseintervention,and1studywasnotwrittenintheEnglish language.Consensuswasreachedtoyieldatotalof5relevant clinicaltrials [4,[9][10][11][12] (fig.1). …”

Section: Yieldmentioning

confidence: 99%

“…Cancerrelated fatigue is characterised by a persistent intense and chronic sense of tiredness [4] that affects quality of life [5], mood [6,7] and physical performance [6,8], and fails to be relievedbyrest [9].Furthermore,thissymptomcanaffectthe courseoftreatment,withfatiguebeingadose-limitingsymptom for some cancer therapies such as interferon and interleukin-2 [10]. The causes of cancer-related fatigue are not understood completely [11].…”

Section: Introductionmentioning

confidence: 99%

Does Exercise Reduce Cancer-Related Fatigue in Hospitalised Oncology Patients? A Systematic Review

Arnold

Taylor

2010

Onkologie

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The primary aim was to find out if exercise reduces cancer-related fatigue in hospitalised oncology patients. Controlled trials of fatigue outcomes after exercise in hospitalised oncology patients were obtained by searching electronic databases. Two reviewers completed data extraction and quality assessment independently. Standardised mean differences and 95% confidence intervals (CI) were determined and a meta-analysis completed. Five relevant trials evaluated 269 hospitalised oncology patients. Meta-analysis of fatigue had an overall standardised mean difference of –0.27 (95% CI –0.62 to 0.08, p = 0.13) in favour of exercise. Evidence from a single trial supported the use of exercise in increasing muscle strength, and there were no significant between-group differences in psychological status and aerobic capacity. Though inconclusive, the findings demonstrate positive trends of reduced cancer-related fatigue in hospitalised oncology patients who exercise. Future adequately powered trials are required to provide evidence to confirm these positive effects.

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Randomized Controlled Trial of a Structured Training Program in Breast Cancer Patients with Tumor-Related Chronic Fatigue

Cited by 52 publications

References 16 publications

Supervised physical exercise improves VO2max, quality of life, and health in early stage breast cancer patients: a randomized controlled trial

Supervised physical exercise improves VO2max, quality of life, and health in early stage breast cancer patients: a randomized controlled trial

Efficacy of Exercise Interventions in Modulating Cancer-Related Fatigue among Adult Cancer Survivors: A Meta-Analysis

Does Exercise Reduce Cancer-Related Fatigue in Hospitalised Oncology Patients? A Systematic Review

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