Randomized controlled trial of 2% lidocaine gel versus water-based lubricant for multi-channel urodynamics

Abstract

Use of 2% lidocaine gel during in and out catheterization, cotton-tipped swab test, and urodynamic testing decreases pain during these procedures.

Lidocaine lubricant jelly does not reduce pain perception during female urethral catheterization: A systematic review with meta‐analysis and trial sequential analysis

“…Harmanli et al 8 studied women who underwent catheterization and Q‐tip test for the complaints of urinary incompetence and/or pelvic organ prolapse. Ozel et al 12 and Kisby et al 7 report their findings for females who underwent catheterization for urodynamic testing. The studies by Harmanli et al 8 and Ozel et al 12 used the Wong–Baker faces pain score, while the others used the VAS 0‐100 mm.…”

“…Ozel et al 12 and Kisby et al 7 report their findings for females who underwent catheterization for urodynamic testing. The studies by Harmanli et al 8 and Ozel et al 12 used the Wong–Baker faces pain score, while the others used the VAS 0‐100 mm. The catheter sizes differed across the studies, ranging from 8 Fr to 16 Fr The volume of the gel used and the dwell time was not available for most of the studies.…”

“…Six RCTs with 464 patients were included in this review 7‐12 . Chan et al 11 , Chung et al 10 and Tanabe et al 9 studied female patients undergoing catheterization in the emergency department.…”

“…From the overall and subgroup analysis (according to the pain score), we did not find any significant difference between the two groups; SMD −0.24 (95% confidence interval (CI) [−0.96, 0.47]) (Figure 3). We also performed subgroup analyses by including studies that investigated intra‐urethral gel instillation (Kisby 7 and Tanabe et al 9 ; SMD 0.38 95% CI (−1.9, 2.65)) and performed urodynamic catheterization (Kisby 7 and Ozel et al 12 ; SMD 0.27 95% CI (−2.23, 2.77)). Random‐effect inverse variance model was used for all the analyses due to the presence of statistically significant heterogeneity in the model (Figure 3).…”

“…In a recently reported randomized controlled trial (RCT), comparing lidocaine and plain jelly in women undergoing flexible cystoscopy, the authors noted significantly reduced pain perception with 2% lidocaine 6 . However, the data regarding the pain perception and lidocaine use during female catheterization are still conflicting 7‐12 . The use of lidocaine lubricant is not risk free.…”