Randomized Controlled Trial Comparing the Efficacy of Terlipressin and Albumin with a Combination of Concurrent Dopamine, Furosemide, and Albumin in Hepatorenal Syndrome

“…All trials used albumin or a similar plasma expander in both treatment and comparator groups. Four studies included both HRS1 and HRS2 patients, but reported results for the HRS1 subgroup independently . Study characteristics are shown in Table .…”

Section: Resultsmentioning

confidence: 99%

Systematic review with meta‐analysis: vasoactive drugs for the treatment of hepatorenal syndrome type 1

Gifford

Morling

Fallowfield

2017

Aliment Pharmacol Ther

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“…Clinical trials comparing standard therapy with terlipressin and albumin with triple therapy of dopamine, albumin and furosemide showed similar results with these approaches [19, 20]. …”

Section: Discussionmentioning

confidence: 99%

Cirrhotic Cardiomyopathy: Another Case of a Successful Approach to Treatment of Hepatorenal Syndrome

Mocarzel

Bicca

Jarske

et al. 2016

Case Rep Gastroenterol

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Hepatorenal syndrome (HRS) is defined as a failure of renal function, potentially reversible, in patients with liver cirrhosis and ascites. Recently, a component of cardiomyopathy associated with HRS was described, but the use of positive inotropic medicine as part of the treatment of the acute phase has not been extensively evaluated. We report a second case in our hospital of a patient with HRS type I without previous heart disease, with secondary hemodynamic decompensation due to liver disease, in which the abnormalities in systolic function by speckle-tracking echocardiography were observed and could be reversed by the use of inotropes. After partial response to current therapies, the patient presented a clinical and laboratorial response with improvement of renal function after infusion of dobutamine. Clinical studies are needed for the therapy approach to HRS taking into account myocardial dysfunction as a major contributing factor for renal dysfunction.

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“…5, However, a recent study showed efficacy of dopamine both in lowering plasma renin activity and in treatment of HRS when used in combination with albumin and furosemide. 6 …”

Section: Correct Answers: a C D And Ementioning

confidence: 99%

Hepatobiliary Quiz Answers—17 (2016)

Rathi

Dhiman

2016

Journal of Clinical and Experimental Hepatology

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Randomized Controlled Trial Comparing the Efficacy of Terlipressin and Albumin with a Combination of Concurrent Dopamine, Furosemide, and Albumin in Hepatorenal Syndrome

Abstract: Concurrent triple therapy improved renal function in HRS and was less expensive than terlipressin (Registration: CTRI/2011/07/001860; www.ctri.nic.in).

Cited by 34 publications

References 24 publications

Systematic review with meta‐analysis: vasoactive drugs for the treatment of hepatorenal syndrome type 1

Systematic review with meta‐analysis: vasoactive drugs for the treatment of hepatorenal syndrome type 1

Cirrhotic Cardiomyopathy: Another Case of a Successful Approach to Treatment of Hepatorenal Syndrome

Hepatobiliary Quiz Answers—17 (2016)

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