Randomized controlled and double-blinded study of Caphosol versus saline oral rinses in pediatric patients with cancer

Immonen, Egle; Aine, L; Nikkil, Atte; Parikka, Mataleena; nroos, Marika Gr; inen, Kaisa Veps l; Palmu, Sauli; Helminen, Mika; ki, Timo Peltom; Lohi, Olli

doi:10.22541/au.158955379.92316344

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“…This implementation could be in the context of routine clinical care or within the design and conduct of clinical trials. (Immonen et al., 2020; Khurana et al., 2013; Ribeiro da Silva et al., 2018; Treister et al., 2017).…”

Section: Discussionmentioning

confidence: 99%

Validation of healthcare professional proxy‐reported children’s International Mucositis Evaluation Scale

et al. 2021

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Objective:The objective was to describe the reliability and validity of the healthcare professional proxy-report version of the Children's International Mucositis Evaluation Scale (ChIMES). Methods:We included pediatric patients who were between 4 and 21 years of age and scheduled to undergo hematopoietic cell transplantation. Mucositis was evaluated by trained healthcare professionals who scored ChIMES, the World Health Organization oral toxicity scale, mouth, and throat pain visual analogue scale, National Cancer Institute-Common Terminology Criteria and the Oral Mucositis Daily Questionnaire.Measures were completed daily and evaluated on days 7-17 post-stem cell infusion for this analysis. Psychometric properties examined were internal consistency, testretest reliability (days 13 and 14), and convergent construct validity.Results: There were 192 participants included. Cronbach's alpha was 0.90 for ChIMES Total Score and 0.93 for ChIMES Percentage Score. Test-retest reliability were as follows: intraclass correlation coefficient (ICC) 0.82 (95% confidence interval (CI) 0.77-0.85) for ChIMES Total Score and ICC 0.82 (95% CI 0.77-0.86) for ChIMES Percentage Score. In terms of construct validation, all correlations between measures met or exceeded those hypothesized (all p < 0.05). Conclusions:The healthcare professional proxy-report version of ChIMES is reliable and valid for children and adolescents undergoing hematopoietic cell transplantation.

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Section: Discussionmentioning

confidence: 99%

Validation of healthcare professional proxy‐reported children’s International Mucositis Evaluation Scale

et al. 2021

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show abstract

Randomized controlled and double-blinded study of Caphosol versus saline oral rinses in pediatric patients with cancer

Abstract: The manuscript contains 3 tables, 3 figures and 2 supplementary figures.

Cited by 1 publication

References 17 publications

Validation of healthcare professional proxy‐reported children’s International Mucositis Evaluation Scale

Validation of healthcare professional proxy‐reported children’s International Mucositis Evaluation Scale

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