Randomized comparison of near-infrared fluorescence lymphatic tracers for sentinel lymph node mapping of cervical cancer

Schaafsma, Boudewijn E.; Vorst, Joost R. van der; Gaarenstroom, Katja N.; Peters, Alexander; Verbeek, F.P.R.; Kroon, Cornelis D. de; Trimbos, J. Baptist; Poelgeest, Mariëtte I.E. van; Frangioni, John V.; Velde, Cornelis J.H. van de; Vahrmeijer, Alexander L.

doi:10.1016/j.ygyno.2012.07.002

Cited by 77 publications

(64 citation statements)

References 25 publications

(21 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, all these data may be organ-dependent, so it is presently unknown if this is also the case in ovarian cancer. Moreover, newly developed hybrid SN detection agents, combining radioactivity with fluorescence or paramagnetic capabilities; alternative operative techniques such as multiphased injection; and new intraoperative imaging technologies may provide additional advantages (24)(25)(26)(27).…”

Section: Discussionmentioning

confidence: 99%

The Detection of Sentinel Nodes in Ovarian Cancer: A Feasibility Study

et al. 2014

View full text Add to dashboard Cite

Few sentinel node (SN) studies in ovarian cancer have been reported, mainly because of the risk of tumor dissemination associated with the injection of tracers into the ovarian cortex. To our knowledge, the injection of tracers into the ovarian ligaments has not been explored. The aim of this study was to determine the feasibility of the SN procedure in ovarian cancer with tracer injection into the ovarian ligaments and to establish whether the procedure is safe for the healthcare workers. Methods: The study included patients who were at high risk of ovarian malignancy. Blue dye and radioactive colloid were injected into the proper ovarian ligament and suspensory ligament of the ovary. To measure professional radiation exposure, ring dose meters were worn by the surgeon, theater nurse, and pathologist during 3 procedures. Results: An SN procedure was performed in 21 patients, and at least 1 SN location was identified in all patients using the γ probe before retroperitoneal exploration. SNs were located in the paraaortic and paracaval regions only in 67% of the patients, in the pelvic region only in 9%, and in both the paraaortic/paracaval and the pelvic regions in 24%. All but 2 SNs were found on the ipsilateral side. In 6 patients who underwent retroperitoneal exploration, 1-4 SNs were identified using the γ probe and resected. Blue-stained SNs were detected in 2 patients. Positive SNs were detected in 1 patient with lymph node metastases. The amount of radiation exposure to the surgeon, theater nurse, and pathologist did not exceed the safe limit. Conclusion: The identification of SNs in all cases suggests that the SN procedure performed by injection of tracers in the ovarian ligaments is feasible and promising. The procedure is safe for the involved personnel. Further investigation is necessary to determine the clinical application of this new technique.

show abstract

Section: Discussionmentioning

confidence: 99%

The Detection of Sentinel Nodes in Ovarian Cancer: A Feasibility Study

et al. 2014

View full text Add to dashboard Cite

show abstract

“…With the recent invention of useful devices such as the Photodynamic Eye (PDE) and Hyper Medical Eye System, ICG fluorescence imaging for SN biopsy has been widely used in various cancer surgeries (18)(19)(20)(21)(22)(23)(24)(25)(26)(27). ICG fluorescence imaging has unique characteristics, including an extra-high sensitivity (26,28) and signal stability (23,26,28).…”

Section: Introductionmentioning

confidence: 99%

Optimal settings and accuracy of indocyanine green fluorescence imaging for sentinel node biopsy in early gastric cancer

et al. 2016

View full text Add to dashboard Cite

Abstract. Indocyanine green (ICG) fluorescence imaging represents a promising method for sentinel node (SN) biopsy in laparoscopic gastric surgery due to its signal stability. In the present study, the suitability and optimal settings of ICG fluorescence imaging for SN biopsy in early gastric cancer were determined. Patients with single primary superficial-type adenocarcinoma of the stomach, lesions <5 cm in diameter, and no evident nodal metastasis and out of indication for endoscopic submucosal dissection were enrolled. The day prior to surgery, ICG solution was endoscopically injected into four quadrants of the submucosal layer of the tumor. The Photodynamic Eye was used to detect ICG fluorescence. Bright nodes were defined as clearly fluorescent nodes. A total of 72 patients were enrolled; 11 cases presented with metastasis, and of these, 10 could be diagnosed by bright node biopsy. The adequate concentration and injection volume of ICG was determined to be 50 µg/ml (x100) and 0.5 mlx4 points, respectively. There was 1 false-negative case, and this was attributed to the failure of the frozen section diagnosis. These results suggested that ICG fluorescence imaging for SN biopsy in laparoscopic surgery for early gastric cancer is feasible. However, a weakness of ICG fluorescence imaging is the subjectivity of bright node evaluation.

show abstract

“…A pseudocolored (lime green) merged image of the color video and NIR fluorescence images is also displayed. The Mini-FLARE™ imaging system allows quantification of the signal intensity, creating results that are objective and comparable, as well as providing real-time NIR fluorescence imaging for image-guided surgery [14,15,16,17]. …”

Section: Methodsmentioning

confidence: 99%

Intraoperative Real-Time Assessment of Liver Function with Near-Infrared Fluorescence Imaging

Narasaki¹,

Noji²,

Wada³

et al. 2017

Eur Surg Res

View full text Add to dashboard Cite

Background: Postoperative liver failure is a serious complication after major hepatectomy, and perioperative prediction of its incidence using current technology is still very difficult. Near-infrared (NIR) fluorescence imaging allows quantitative assessment of the fluorescent signal from indocyanine green (ICG) in regions of interest on the liver surface. This method might offer a new promising modality for evaluating regional liver reserve. However, data are lacking regarding the relationship between liver function and fluorescent signals on the liver surface after intravenous ICG injection. This study was conducted to obtain the data necessary to apply NIR fluorescence imaging as a modality for measuring liver function. Materials and Methods: This study included 16 patients who underwent open hepatopancreatobiliary surgery between March 2011 and March 2012. After laparotomy, ICG was injected intravenously at 2.5 mg/L of liver volume, then the fluorescence intensity (FI) and signal-to-background ratio (SBR) in the lateral segment of the liver were assessed for 15 min. Intraoperative blood samples were also obtained to measure the plasma clearance rate of ICG (ICGK). Correlations between ICGK, liver volume, and SBR, as well as between ICGK, liver volume, and rate of change of FI were analyzed. Results: The experimental procedure was performed in all 16 patients. The FI of the liver increased rapidly after ICG injection, then became more gradual, reaching a near-plateau after 15 min. A significant correlation was seen between ICGK and the rate of change of FI up to 15 min (|rS| = 0.5725, p < 0.05). Conclusion: This is the first report to show a relationship between liver function and fluorescent signals on the liver surface after intravenous ICG injection. Intraoperative NIR fluorescence imaging with ICG may be useful as a new method for assessing liver function.

show abstract

Randomized comparison of near-infrared fluorescence lymphatic tracers for sentinel lymph node mapping of cervical cancer

Cited by 77 publications

References 25 publications

The Detection of Sentinel Nodes in Ovarian Cancer: A Feasibility Study

The Detection of Sentinel Nodes in Ovarian Cancer: A Feasibility Study

Optimal settings and accuracy of indocyanine green fluorescence imaging for sentinel node biopsy in early gastric cancer

Intraoperative Real-Time Assessment of Liver Function with Near-Infrared Fluorescence Imaging

Contact Info

Product

Resources

About