Randomized Clinical Trial to Assess the Efficacy of a Comprehensive Programme of Secondary Prevention of Cardiovascular Disease in General Practice: The PREseAP Study

Brotons, Carlos; Soriano, Núria; Moral, Irene; Rodrigo, María Pilar; Kloppe, Pilar; Rodríguez, Ana Iglesias; González, María Luisa Soriano; Ariño, Dolores; Orozco, D.; Buitrago, Francisco; Pepió, J.M.; Borrás, Isabel

doi:10.1016/j.rec.2010.06.007

Cited by 20 publications

(40 citation statements)

References 17 publications

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“…The studies by Reid et al consisted of two separate programmes, one internet based [23], the other one by phone counselling [24] and these were named and considered accordingly. Four studies included patients with other cardiovascular diseases than coronary artery disease including peripheral vascular disease and ischaemic stroke [21,[25][26][27]. In total, 989 patients in this meta-analysis were diagnosed with other cardiovascular diseases.…”

Section: Included Studiesmentioning

confidence: 99%

Lessons from contemporary trials of cardiovascular prevention and rehabilitation: A systematic review and meta-analysis

Halewijn

Deckers

Tay

et al. 2017

International Journal of Cardiology

133

110

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Comprehensive prevention and rehabilitation programmes managing six or more risk factors, and those prescribing and monitoring medications within programmes to lower blood pressure and lipids, continue to reduce all-cause mortality. In addition, these comprehensive programmes not only reduced cardiovascular mortality and myocardial infarction but also, for the first time, cerebrovascular events, and all these outcomes across a broader spectrum of patients with atherosclerotic disease.

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Section: Included Studiesmentioning

confidence: 99%

Lessons from contemporary trials of cardiovascular prevention and rehabilitation: A systematic review and meta-analysis

Halewijn

Deckers

Tay

et al. 2017

International Journal of Cardiology

133

110

View full text Add to dashboard Cite

show abstract

“…The novel research paradigms required to conduct comparative effectiveness research entail unique challenges as illustrated by the present study by Brotons et al 4 Cluster randomized trials must account for clustering in the sample size calculations 6 as was done in the Brotons study. 4 In addition, to ensure internal validity, the allocation status must be masked to those who identifying or recruit individuals into the trial.…”

Section: Why Are the Results Essentially Negative When Prior Studies mentioning

confidence: 93%

“…4 In addition, to ensure internal validity, the allocation status must be masked to those who identifying or recruit individuals into the trial. 6 This may be difficult to achieve, as, in cluster randomized trials, there are two levels of participation: the cluster and the individual.…”

Section: Why Are the Results Essentially Negative When Prior Studies mentioning

confidence: 99%

“…Another consideration is that optimizing healthy habits and reducing depression has benefits that extend beyond the cardiovascular subsystem and is likely to also favorably impact other outcomes such as quality of life and/or health care utilization. Finally, all patients in the study by Brotons et al 4 had cardiovascular disease but with diverse clinical manifestations (including coronary disease, cerebrovascular disease or peripheral arterial disease). The intervention was similar, regardless of the type of manifestation of cardiovascular disease.…”

Section: What Are the Clinical And Research Implications Of This Study?mentioning

confidence: 97%

“…The study by Brotons et al, published in this issue of Revista Española de Cardiologia 4 contributes to address this gap in knowledge by evaluating the efficacy of secondary prevention between 2004 and 2005. The authors report on 1224 patients with cardiovascular disease (coronary disease, cerebrovascular disease or peripheral arterial disease) from 42 practices in Spain, similarly distributed between control and intervention, the latter consisting of education and structured intervention based on the patient's risk factor profile.…”

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confidence: 99%

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Secondary Prevention: The Ongoing Challenge

Roger

2011

Revista Española de Cardiología (English Edition)

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Exercise for intermittent claudication

Lane

Harwood

Watson

et al. 2017

Cochrane Database of Systematic Reviews

319

156

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Background Exercise programmes are a relatively inexpensive, low-risk option compared with other, more invasive therapies for treatment of leg pain on walking (intermittent claudication (IC)). This is the fourth update of a review first published in 1998. Objectives Our goal was to determine whether an exercise programme was effective in alleviating symptoms and increasing walking treadmill distances and walking times in people with intermittent claudication. Secondary objectives were to determine whether exercise was effective in preventing deterioration of underlying disease, reducing cardiovascular events, and improving quality of life. Search methods For this update, the Cochrane Vascular Information Specialist searched the Specialised Register (last searched 15 November 2016) and the Cochrane Central Register of Controlled Trials (CENTRAL; 2016, Issue 10) via the Cochrane Register of Studies Online, along with trials registries. Selection criteria Randomised controlled trials of an exercise regimen versus control or versus medical therapy for people with IC due to peripheral arterial disease (PAD). We included any exercise programme or regimen used for treatment of IC, such as walking, skipping, and running. Inclusion of trials was not affected by duration, frequency, or intensity of the exercise programme. Outcome measures collected included treadmill walking distance (time to onset of pain or pain-free walking distance and maximum walking time or maximum walking distance), ankle brachial index (ABI), quality of life, morbidity, or amputation; if none of these was reported, we did not include the trial in this review. Data collection and analysis For this update (2017), RAL and AH selected trials and extracted data independently. We assessed study quality by using the Cochrane 'Risk of bias' tool. We analysed continuous data by determining mean differences (MDs) and 95% confidence intervals (CIs), and dichotomous data by determining risk ratios (RRs) and 95% CIs. We pooled data using a fixed-effect model unless we identified significant heterogeneity, in which case we used a random-effects model. We used the GRADE approach to assess the overall quality of evidence supporting the outcomes assessed in this review.

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Randomized Clinical Trial to Assess the Efficacy of a Comprehensive Programme of Secondary Prevention of Cardiovascular Disease in General Practice: The PREseAP Study

Cited by 20 publications

References 17 publications

Lessons from contemporary trials of cardiovascular prevention and rehabilitation: A systematic review and meta-analysis

Lessons from contemporary trials of cardiovascular prevention and rehabilitation: A systematic review and meta-analysis

Secondary Prevention: The Ongoing Challenge

Exercise for intermittent claudication

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