Randomized clinical trial of the effect of perioperative synbiotics <i>versus</i> no synbiotics on bacterial translocation after oesophagectomy

Yokoyama, Yukihiro; Nishigaki, Eiji; T, Abe; Fukaya, Masahide; Asahara, Takashi; Nomoto, Koji; Nagino, Masato

doi:10.1002/bjs.9385

Cited by 56 publications

(65 citation statements)

References 23 publications

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“…This takes the form of defense against bacterial translocation and infectious complications in seriously ill patients, including perioperative patients with bile duct cancer (21,39), esophageal cancer (51,52), hepatic cirrhosis (53), and colorectal cancer (54), patients undergoing cancer chemotherapy (55), systemic inflammatory response syndrome (SIRS) patients (40), and patients on long-term mechanical ventilation (56). Moreover, research has suggested that improvement of dysbiosis and activity to improve the intestinal environment (pH and organic acid [acetic acid] level) are important in the mechanism for this protective effect against infections.…”

Section: Figmentioning

confidence: 99%

Protective Effect of a Synbiotic against Multidrug-Resistant Acinetobacter baumannii in a Murine Infection Model

Asahara

Takahashi

Yuki

et al. 2016

Antimicrob Agents Chemother

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Section: Figmentioning

confidence: 99%

Protective Effect of a Synbiotic against Multidrug-Resistant Acinetobacter baumannii in a Murine Infection Model

Asahara

Takahashi

Yuki

et al. 2016

Antimicrob Agents Chemother

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“…Administration of synbiotics prevented postoperative deterioration of the intestinal microfloral environment and suppressed excessive inflammatory response, possibly by exerting immunomodulatory effects and by inhibiting bacterial translocation [88,89]. Additionally, synbiotics led to decreased incidence of severe diarrhea and lower interruption or reduction of enteral nutrition.…”

Section: Esophageal Abnormalitiesmentioning

confidence: 99%

Nutritional Management of Esophageal Cancer Patients

Schizas¹,

Lidoriki²,

Moris³

et al. 2017

Esophageal Abnormalities

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Esophageal cancer is associated with malnutrition in the vast majority of patients. This phenomenon is partly attributed to the disease process itself, the location of the tumor and other factors, such as dysphagia which is often accentuated due to chemotherapy/ radiotherapy treatment or surgical intervention. The poor nutritional status of these patients is often related to the presence of cancer cachexia, altered metabolism, and tissue wasting. Malnutrition in this patient population affects quality of life, worsens patient's tolerance to chemotherapy and accounts for lower survival. Nutritional management of these patients includes both proper nutritional assessment and support and might prevent, to a certain extent, the manifestation of malnutrition-related consequences. The purpose of this article is to review the current literature in order to focus on the etiology and diagnosis of malnutrition in esophageal cancer patients, emphasizing also on the optimal nutritional support during multimodality treatment.

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“…This high analytical sensitivity enables more accurate and reliable detection (compared with conventional culture methods) of microorganisms that have migrated into the bloodstream, a condition known as bacteremia. Using this method, bacteremia was detected far earlier, and in some cases unexpectedly, in individuals, including adults subjected to invasive abdominal surgery [2] and pediatric surgical patients [5]. The analytical method was found to be useful for the detection of bacteremia in pediatric patients with febrile neutropenia (mucositis) [6], type 2 diabetes [7], and ischemic stroke [8].…”

Section: A Cutting-edge Analytical Methods For Detection Of Bacteria Imentioning

confidence: 99%

“…This study group also demonstrated these findings in the context of dysbiosis-related deteriorations of the gut environment [9]. One of the excellent papers of Prof. Y. Yokoyama’s group [5] is summarized below.…”

Section: Bacteremia In Highly Invasive Abdominal Surgery and Its Prevmentioning

confidence: 99%

Gut Microbiota in Health and Disease

Yamashiro¹

2017

Ann Nutr Metab

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Intestinal regulatory T (Treg) cells are critical to maintaining immune tolerance to dietary antigens and gut microbiota. This paper reviews several papers on this topic that were recently published by Japanese researchers. Specifically, Prof. K. Honda and his group have found that commensal microbiota capable of metabolizing butyrate induces the differentiation of colonic Treg cells. In a separate work, Prof. Y. Yokoyama and his group used a novel, culture-independent analytical method (the Yakult Intestinal Flora-Scan) for detection of bacteria in the bloodstream. Their work revealed that bacteremia in invasive surgery patients was ameliorated by synbiotic supplementation; similar results were reported in pediatric surgical cases by Dr. T. Okazaki and his group. This cutting-edge method may lead to the evolution of an altered disease concept; an example of this change is provided by the description of bacteremia in patients with type 2 diabetes, as reported by Dr. J. Sato and her group. In a similar work, Prof. Y. Yamashiro and his group found that infants born by cesarean (C)-section, who typically have gut dysbiosis, exhibit higher carriage of toxigenic Clostridium perfringens. The finding suggests that C-section-born infants may serve as a potential reservoir of this opportunistic pathogen. Another separate work by the laboratory of Dr. K. Yamashiro has revealed that gut dysbiosis is associated with altered metabolism and systemic inflammation in patients with ischemic stroke. These papers are consistent with a study by Prof. N. Sudo and his group, who have made significant progress in research on interaction among the microbiota, gut, and brain.

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Randomized clinical trial of the effect of perioperative synbiotics versus no synbiotics on bacterial translocation after oesophagectomy

Abstract: ID 000003262 (University Hospital Medical Information Network, http://www.umin.ac.jp).

Cited by 56 publications

References 23 publications

Protective Effect of a Synbiotic against Multidrug-Resistant Acinetobacter baumannii in a Murine Infection Model

Protective Effect of a Synbiotic against Multidrug-Resistant Acinetobacter baumannii in a Murine Infection Model

Nutritional Management of Esophageal Cancer Patients

Gut Microbiota in Health and Disease

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