Randomized Clinical Trial of Plantago Ovata Seeds (Dietary Fiber) As Compared With Mesalamine in Maintaining Remission in Ulcerative Colitis

Fernández‐Bañares, Fernando; Hinojosa, Joaquín; Sánchez-Lombraña, J L; Navarro, E.; Martínez-Salmerón, J F; García-Pugés, A; González-Húix, Ferrán; Riera, Joan; González-Lara, V.; Domínguez-Abascal, F.; Giné, J.; Molés, J R; Gomollón, Fernando; Gassull, Miquel A.

doi:10.1111/j.1572-0241.1999.872_a.x

Cited by 299 publications

(136 citation statements)

References 28 publications

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“…It was demonstrated that colonic fermentation of Plantago ovata seeds yields butyrate, which serves as a nutrient for intestinal epithelial cells. The presence of butyrate in inflammatory bowel disease (IBD) in humans reduced the inflammation by inhibiting the production of cytokines and the activation of the transcription factor nuclear factor -kappa B (NF-κB) (Fernandez-Banares et al, 1999). In addition, butyrate protects the intestinal mucosa against injury and promotes mucosal healing (Scheppach et al, 1992).…”

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confidence: 99%

Short Communication Effects of short chain fatty acid (SCFA) supplementation on performance and egg characteristics of old breeder hens

Şengör¹,

Yardimci²,

Çetingül³

et al. 2007

SA J. An. Sci.

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A study was conducted to determine the effect of supplementing the diet of breeder hens with a shortchain fatty acid (SCFA) premix, containing 509 g fatty acid salts/kg of which 285 g were calcium butyrate, on their eggshell characteristics and the hatching percentage of the eggs. One thousand six hundred 66-week old White Bovans laying breeder hens were used in this experiment. They were housed in eight identical pens, each containing 200 birds, and four pens were used per treatment. The SCFA premix was included at 1000 mg/kg in the treatment diet, and fed for a period of nine weeks. Responses were compared with an unsupplemented treatment. Supplementation started when the hens were 66 weeks old. From day 75 eggs were collected for the next seven weeks and the occurrence of cracked, dirty and misshapen eggs was recorded, and the hatching percentage of the eggs was determined. Eggshell strength was lower in eggs from the control (1.76 ± 0.05) than from the treatment group (2.07 ± 0.03). The percentage of eggs produced by the control group (68.6 ± 0.08) was significantly lower than that by the supplemented group (71.5 ± 0.15). Percentage of dirty, cracked and misshapen eggs, and the hatchability percentage of the control group (1.15 ± 0.03, 3.44 ± 0.05, 6.27 ± 0.03 and 88.93 ± 0.06, respectively) were also significantly lower than in the group receiving SCFA (0.47 ± 0.03, 2.21 ± 0.03, 3.81 ± 0.03 and 93.36 ± 0.05, respectively). It was concluded that dietary supplementation of SCFA to layer breeder hens from 66 weeks of age onwards improved eggshell strength, reduced the percentage of dirty, cracked and misshapen eggs and increased the hatching percentage of the eggs. The positive responses were suggested to be largely due to the butyrate in the SCFA. _______________________________________________________________________________________

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mentioning

confidence: 99%

Short Communication Effects of short chain fatty acid (SCFA) supplementation on performance and egg characteristics of old breeder hens

Şengör¹,

Yardimci²,

Çetingül³

et al. 2007

SA J. An. Sci.

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“…The rate of relapse in patients with quiescent UC treated with soluble dietary fiber was not higher than that of patients given 5-ASA at the usual maintenance dose (5). Although the intake of dietary fiber, both soluble and insoluble, in the present UC patients was the same as that in the controls, the total fiber intake was less than that considered adequate for adult Japanese (29).…”

Section: Discussionmentioning

confidence: 55%

Dietary Intake, Neutrophil Fatty Acid Profile, Serum Antioxidant Vitamins and Oxygen Radical Absorbance Capacity in Patients with Ulcerative Colitis

Kawakami

Okada

Murakami

et al. 2007

J Nutr Sci Vitaminol

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Summary Nutrition may play an important role in the pathogenesis and treatment of ulcerative colitis. Several studies suggest an association between dietary factors and the onset of ulcerative colitis; however, only few studies have examined the relationship between dietary intake and relapse of ulcerative colitis. The aim of this study was to assess the dietary intake and antioxidative capacity of ulcerative colitis patients and to elucidate the efficacy of dietary therapy for ulcerative colitis. Dietary intake, fatty acid composition of phospholipids in plasma and neutrophils, serum fat-soluble vitamin levels, and oxygen radical absorbance capacity were analyzed in 29 ulcerative colitis patients (7 males and 22 females), who were treated at the Department of Gastroenterology, Okayama University Hospital. Total fat intake, fat energy ratio and linoleic acid intake were significantly lower, while protein and carbohydrate intakes were significantly higher, in the patients than age-and sex-matched controls. In the neutrophil phospholipids of ulcerative colitis patients, significantly higher levels of linoleic aicd and arachidonic acid and a lower level of eicosapentaenoic acid were observed. The concentrations of serum retinol and ␤ -carotene but not ␣ -tocopherol were significantly lower and serum oxygen radical absorbance capacity was also lower than in the controls. Significant correlations between serum oxygen radical absorbance capacity and retinol ( r ϭ 0.567, p ϭ 0.0031), ␣ -tocopherol ( r ϭ 0.560, p ϭ 0.0036) and ␤ -carotene ( r ϭ 0.440, p ϭ 0.0279) concentrations were observed in the ulcerative colitis patients. A diet restricting the intake of linoleic acid and supplemented with eicosapentaenoic acid and antioxidative vitamins may be recommendable for the nutritional management of ulcerative colitis patients.

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“…Soluble fibers are a different issue. There are studies suggesting that food products rich in soluble fibers, particularly germinated barley food stuff and seeds of the plantago ovata plant, might have positive effects in UC patients (20)(21)(22). It is known that short-chain fatty acids such as butyrate, which is a degradation product of soluble fibers, have positive effects on colonocytes.…”

Section: Resultsmentioning

confidence: 99%

Ulcerative colitis and diet

Çekiç¹,

Ünsal²

2012

Turk J Gastroenterol

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Randomized Clinical Trial of Plantago Ovata Seeds (Dietary Fiber) As Compared With Mesalamine in Maintaining Remission in Ulcerative Colitis

Abstract: Plantago ovata seeds (dietary fiber) might be as effective as mesalamine to maintain remission in ulcerative colitis.

Cited by 299 publications

References 28 publications

Short Communication Effects of short chain fatty acid (SCFA) supplementation on performance and egg characteristics of old breeder hens

Short Communication Effects of short chain fatty acid (SCFA) supplementation on performance and egg characteristics of old breeder hens

Dietary Intake, Neutrophil Fatty Acid Profile, Serum Antioxidant Vitamins and Oxygen Radical Absorbance Capacity in Patients with Ulcerative Colitis

Ulcerative colitis and diet

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