Randomized Clinical Trial of Extended Spectrum Antibiotic Prophylaxis With Coverage for Ureaplasma urealyticum to Reduce Post–Cesarean Delivery Endometritis

Andrews, William; Hauth, John C.; Cliver, Suzanne P.; Savage, Karen; Goldenberg, Robert L.

doi:10.1097/00006250-200306000-00010

Cited by 24 publications

(48 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Shehla et al (21) had reported the incidence of puerperal pyrexia as 44.7% and Jolly et al (16) as 7.58%. Incidence of wound infection had been reported as 6% by Chaim et al (30) and 2% by Andrews et al (31) Incidence of Chorioamnionitis had been reported as 4% by Hannah et al (2) and 1.6% by Ottervanger et al (32) In our study, significant number of neonates (27.6%) required NICU observation for mild respiratory distress and 5.3% of neonates were admitted in NICU for perinatal asphyxia and 2.6% of neonates were admitted for neonatal sepsis. There were no perinatal deaths.…”

Section: Discussionsupporting

confidence: 45%

Evaluation of Maternal and Foetal Outcome in Term Premature Rupture of Membranes Managed With Early Induction

P¹,

Jalakandan²

2016

jemds

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 45%

Evaluation of Maternal and Foetal Outcome in Term Premature Rupture of Membranes Managed With Early Induction

P¹,

Jalakandan²

2016

jemds

View full text Add to dashboard Cite

show abstract

“…The same investigators later provided indirect evidence that ureaplasmas may be involved in post-Cesarean delivery endometritis in a study in which 301 women who received doxycycline plus azithromycin were compared to 297 who received a placebo (16). The interesting finding in that investigation was that prophylaxis with antibiotics having activity against ureaplasmas reduced the length of hospitalization, frequency of endometritis, and wound infections.…”

Section: Postpartum Endometritismentioning

confidence: 99%

Mycoplasmas and Ureaplasmas as Neonatal Pathogens

Katz²,

2005

View full text Add to dashboard Cite

SUMMARY The genital mycoplasmas represent a complex and unique group of microorganisms that have been associated with a wide array of infectious diseases in adults and infants. The lack of conclusive knowledge regarding the pathogenic potential of Mycoplasma and Ureaplasma spp. in many conditions is due to a general unfamiliarity of physicians and microbiology laboratories with their fastidious growth requirements, leading to difficulty in their detection; their high prevalence in healthy persons; the poor design of research studies attempting to base association with disease on the mere presence of the organisms in the lower urogenital tract; the failure to consider multifactorial aspects of diseases; and considering these genital mycoplasmas only as a last resort. The situation is now changing because of a greater appreciation of the genital mycoplasmas as perinatal pathogens and improvements in laboratory detection, particularly with regard to the development of powerful molecular nucleic acid amplification tests. This review summarizes the epidemiology of genital mycoplasmas as causes of neonatal infections and premature birth; evidence linking ureaplasmas with bronchopulmonary dysplasia; recent changes in the taxonomy of the genus Ureaplasma; the neonatal host response to mycoplasma and ureaplasma infections; advances in laboratory detection, including molecular methods; and therapeutic considerations for treatment of systemic diseases.

show abstract

“…[11][12][13][14] A recent cohort study confirmed a corresponding drop in rates of post caesarean endometritis with increasing use of azithromycin based Extended spectrum prophylaxis. 15 However, antibiotic to be chosen depends on antimicrobial susceptibility patterns in the local hospitals, in our hospital, microbes are multidrug resistant including Ampicillin and Azythromycine.…”

Section: 10mentioning

confidence: 99%

To study the effectiveness of prophylactic use of ceftriaxone (single dose) in caesarean section in low risk patients in a tertiary care center, Moradabad, India

et al. 2017

View full text Add to dashboard Cite

Background: There is increasing incidence of caesarean section throughout the world. As caesarean section is associated with infectious complications which increase the rate of morbidity and mortality of mothers. For prevention of infectious complications antibiotics are used but careless use of antibiotics increasing incidence of antibiotic resistance. Many guidelines and studies recommend single dose antibiotic prophylaxis for women undergoing elective or non-elective caesarean section. The aim of this study was to assess the effectiveness of Ceftriaxone as prophylactic antibiotic (single dose) in caesarean section in low risk patients.Methods: A Prospective single blind study was carried out in the department of obstetrics and gynaecology, TMMC and RC Moradabad, a tertiary care center, in all low risk patients underwent for Elective and Emergency Lower segment caesarean section for 1 year from 1st June 2015 to May 2016 on 110 patients. Data was collected and analyzed by percentage and proportion.Results: Prevalence of caesarean section was maximum in women of 26-35years age group (52.72%),about 67.27% was emergency LSCS, most common indication of caesarean section was Fetal distress (29.09%),refusal for vaginal delivery after caesarean section (10.90%) was one of the cause for increasing rate of repeat caesarean section, 41.81% women in labour,72.27% cases were with intact membrane, in 9.09% cases, antibiotic had to change in post-operative period due to urinary tract infection and surgical site infection, most common post-operative complication was superficial surgical site infection with purulent discharge (2.72%). No major life-threatening complication occurred.Conclusions: Single dose of Ceftriaxone is effective for prevention of post-caesarean infectious complication.

show abstract

Randomized Clinical Trial of Extended Spectrum Antibiotic Prophylaxis With Coverage for Ureaplasma urealyticum to Reduce Post–Cesarean Delivery Endometritis

Cited by 24 publications

References 12 publications

Evaluation of Maternal and Foetal Outcome in Term Premature Rupture of Membranes Managed With Early Induction

Evaluation of Maternal and Foetal Outcome in Term Premature Rupture of Membranes Managed With Early Induction

Mycoplasmas and Ureaplasmas as Neonatal Pathogens

To study the effectiveness of prophylactic use of ceftriaxone (single dose) in caesarean section in low risk patients in a tertiary care center, Moradabad, India

Contact Info

Product

Resources

About