Randomized clinical trial of autologous skin cell suspension for accelerating re-epithelialization of split-thickness donor sites

Hu, Zhicheng; Guo, Dong; Liu, Peng; Cao, Xiaoling; Li, S; Zhu, Jiayuan; Tang, Bin

doi:10.1002/bjs.10508

Cited by 28 publications

(13 citation statements)

References 28 publications

(50 reference statements)

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“… 13 , 23 , 24 In addition, ReCell treatment to the donor sites has previously been shown to significantly improve donor site healing. 15 Therefore, based on the collective data, the authors conclude that the results demonstrated in this study may be extrapolated for the treatment of all deep-partial thickness thermal burns.…”

Section: Discussionmentioning

confidence: 65%

“…Preclinical data demonstrate that ASCS contains a mixed population of skin cells found at the dermoepidermal junction of predominantly keratinocyte, fibroblast, and melanocyte phenotypes. 12 ReCell-generated ASCS has been used to treat a wide variety of wound conditions such as burns, 13 , 14 STSG donor sites, 15 chronic wounds, 16 , 17 hypopigmented scars, 18 vitiligo, 19 , 20 and large congenital melanotic nevus. 21 A randomized study conducted by Gravante et al demonstrated that deep partial-thickness burns treated with ASCS produced using the ReCell device showed similar results to standard skin grafting, with the use of significantly less donor skin.…”

mentioning

confidence: 99%

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A Comparative Study of the ReCell® Device and Autologous Split-Thickness Meshed Skin Graft in the Treatment of Acute Burn Injuries

Holmes

Molnár

Carter

et al. 2018

Journal of Burn Care &Amp; Research

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Early excision and autografting are standard care for deeper burns. However, donor sites are a source of significant morbidity. To address this, the ReCell® Autologous Cell Harvesting Device (ReCell) was designed for use at the point-of-care to prepare a noncultured, autologous skin cell suspension (ASCS) capable of epidermal regeneration using minimal donor skin. A prospective study was conducted to evaluate the clinical performance of ReCell vs meshed split-thickness skin grafts (STSG, Control) for the treatment of deep partial-thickness burns. Effectiveness measures were assessed to 1 year for both ASCS and Control treatment sites and donor sites, including the incidence of healing, scarring, and pain. At 4 weeks, 98% of the ASCS-treated sites were healed compared with 100% of the Controls. Pain and assessments of scarring at the treatment sites were reported to be similar between groups. Significant differences were observed between ReCell and Control donor sites. The mean ReCell donor area was approximately 40 times smaller than that of the Control (P < .0001), and after 1 week, significantly more ReCell donor sites were healed than Controls (P = .04). Over the first 16 weeks, patients reported significantly less pain at the ReCell donor sites compared with Controls (P ≤ .05 at each time point). Long-term patients reported higher satisfaction with ReCell donor site outcomes compared with the Controls. This study provides evidence that the treatment of deep partial-thickness burns with ASCS results in comparable healing, with significantly reduced donor site size and pain and improved appearance relative to STSG.

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Section: Discussionmentioning

confidence: 65%

mentioning

confidence: 99%

A Comparative Study of the ReCell® Device and Autologous Split-Thickness Meshed Skin Graft in the Treatment of Acute Burn Injuries

Holmes

Molnár

Carter

et al. 2018

Journal of Burn Care &Amp; Research

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“…Recently, novel concepts like an autologous skin cell suspension has shown accelerated healing rates in donor site wounds [7], but fails to compare this to more conventional and readily available dressing approaches. Moreover, cost is a determining and mitigating factor, especially in the South African State Care setting: a resource constrained environment.…”

Section: Discussionmentioning

confidence: 99%

A Prospective, Within-Patient Controlled Study to Compare the Ability of the Non Adherent Drawtex® Hydroconductive Dressing to a Transparent Polyurethane Film Dressing (Standard of Care) on the Healing of Split-Thickness Skin Graft Donor Sites*

Bergh¹,

Kruger²,

Kourie³

et al. 2018

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Background: Dressing of split-thickness skin graft donor sites can be traumatic for the patient. The most advanced and expensive dressings have been compared to the most basic of dressings, with little or no consensus and an unpersuasive level of evidence. We aimed to determine the efficacy of the locally manufactured non-adherent, hydroconductive Drawtex® dressing and compare it to our current standard-of-care dressing, a thin transparent polyurethane film, in the healing of split-thickness donor sites. Methods: This prospective, within-patient controlled study included 27 adult participants, each with two split-thickness skin donor sites. The 54 donor site wounds were compared with regard to time to re-epithelialisation, perceived pain and healed wound quality. Results: By day 5, complete healing of donor site wounds, defined as >90% of epithelialized surface, was significantly higher in the hydroconductive dressing group compared to the polyurethane film group (22.2% and 3.7%, respectively; p < 0.0001). The hydroconductive dressing-treated donor site wounds were significantly less painful at 24-hours, *A research report on the original work presented in this article has been approved in partial fulfilment of the requirements for the degree of Master of Medicine by the University of the Witwatersrand.

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“…Using the scalp or harvest thinner grafts could potentially shorten healing times at the donor sites [138,139] and save melanocytes in epidermal appendages, the latter to reduce the risk of hypopigmentation. Other surgical techniques such as dermis grafts can be advocated [140] or resurfacing the donor sites with thin grafts [141]; minced grafts [142]or by adding autologous skin cells [143].…”

Section: Factors Predicting Scarring Of Partial Thickness Burns (Studmentioning

confidence: 99%

Studying the healing and long-term outcomes of two partial thickness wound models using different wound dressings

Karlsson

2019

Linköping University Medical Dissertations

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Background: Safe and effective wound dressing treatments are important for proper wound healing. Such procedures therefore need to be evidence-based regarding the most important outcome measures such as healing time, less discomfort for the patient, duration of hospital care and, importantly, less scarring. As the relation between longer healing times and more severe scarring is known, it is important to find dressing treatments that reduces such complications by providing fast and proper wound healing. In this thesis, four established wound dressing treatments (hydrofibre covered with film; porcine xenografts and polyurethane foam, with and without silver), were evaluated for two types of acute, partial thickness wounds: split thickness skin graft (STSG) donor sites and partial thickness burn wounds in two randomised, controlled clinical trials (RCT) with longterm scar follow ups. The relations between factors thought to influence wound healing and scarring as sex, infection, wound extent and depth, healing time and skin grafting were also investigated in these two wound models. Methods: Data from these trials were collected on sex, infection rates, wound depth and extent, need of skin grafting, healing times and scarring frequency together with demographic data. Scars were evaluated at 8 years in Study II and III and at 6 and 12 months after injury in Study V.

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Randomized clinical trial of autologous skin cell suspension for accelerating re-epithelialization of split-thickness donor sites

Abstract: The use of autologous skin cell suspension with hydrocolloid dressings accelerated epithelialization and improved healing quality of the donor site compared with hydrocolloid dressings alone. Registration number: UMIN000015000 ( http://www.umin.ac.jp/ctr).

Cited by 28 publications

References 28 publications

A Comparative Study of the ReCell® Device and Autologous Split-Thickness Meshed Skin Graft in the Treatment of Acute Burn Injuries

A Comparative Study of the ReCell® Device and Autologous Split-Thickness Meshed Skin Graft in the Treatment of Acute Burn Injuries

A Prospective, Within-Patient Controlled Study to Compare the Ability of the Non Adherent Drawtex® Hydroconductive Dressing to a Transparent Polyurethane Film Dressing (Standard of Care) on the Healing of Split-Thickness Skin Graft Donor Sites*

Studying the healing and long-term outcomes of two partial thickness wound models using different wound dressings

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Randomized clinical trial of autologous skin cell suspension for accelerating re-epithelialization of split-thickness donor sites

Abstract: The use of autologous skin cell suspension with hydrocolloid dressings accelerated epithelialization and improved healing quality of the donor site compared with hydrocolloid dressings alone. Registration number: UMIN000015000 ( http://www.umin.ac.jp/ctr).

Cited by 28 publications

References 28 publications

A Comparative Study of the ReCell® Device and Autologous Split-Thickness Meshed Skin Graft in the Treatment of Acute Burn Injuries

A Comparative Study of the ReCell® Device and Autologous Split-Thickness Meshed Skin Graft in the Treatment of Acute Burn Injuries

A Prospective, Within-Patient Controlled Study to Compare the Ability of the Non Adherent Drawtex&#174; Hydroconductive Dressing to a Transparent Polyurethane Film Dressing (Standard of Care) on the Healing of Split-Thickness Skin Graft Donor Sites*

Studying the healing and long-term outcomes of two partial thickness wound models using different wound dressings

Contact Info

Product

Resources

About

A Prospective, Within-Patient Controlled Study to Compare the Ability of the Non Adherent Drawtex® Hydroconductive Dressing to a Transparent Polyurethane Film Dressing (Standard of Care) on the Healing of Split-Thickness Skin Graft Donor Sites*