Randomized, blinded, controlled clinical trial shows no benefit of homeopathic mastitis treatment in dairy cows

Ebert, Fanny; Staufenbiel, R.; Simons, Julia; Pieper, Laura

doi:10.3168/jds.2016-11805

Cited by 12 publications

(9 citation statements)

References 43 publications

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“… a According to Wildman et al (1982) . b Cows were screened for mastitis prior to every milking (d –7 to 84) using the strip cup method, whereas clinical mastitis was defined as a change in milk secretion (e.g., flakes) and external evidence of udder inflammation (e.g., hardening and redness) as in Ebert et al (2017) . c Total cases of mastitis divided by number of cows within each treatment group.…”

Section: Resultsmentioning

confidence: 99%

“…Cows were monitored daily during the entire experimental period (d –7 to 84) for incidence of morbidity or mortality by trained personnel ( Lima et al, 2012 ). Cows were screened for mastitis before every milking using the strip cup method, whereas clinical mastitis was defined as a change in milk secretion (e.g., flakes) and external evidence of udder inflammation (e.g., hardening and redness) as in Ebert et al (2017) . Cows diagnosed with mastitis were treated with ceftiofur hydrochloride (Spectramast LC; Zoetis, São Paulo, Brazil) for 5 consecutive days on diagnosis as recommended by the manufacturer, whereas milk yield was recorded but milk was discarded for 8 consecutive days after diagnosis.…”

Section: Methodsmentioning

confidence: 99%

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Productive and physiological responses of lactating dairy cows supplemented with phytogenic feed ingredients1

Rodrigues

Cooke

Firmino

et al. 2019

Translational Animal Science

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This experiment compared milk production, milk composition, and physiological responses in lactating dairy cows supplemented with or without a mixture of condensed tannins, encapsulated cinnamaldehyde, curcumin, capsaicin, and piperine. Thirty-six lactating, multiparous, pregnant ¾ Holstein × ¼ Gir cows were maintained in a single drylot pen with ad libitum access to water and a total-mixed ration and were milked twice daily (d –7 to 84). On d 0, cows were ranked by days in milk (86 ± 3 d), milk yield (27.8 ± 1.0 kg), body weight (BW; 584 ± 10 kg), and body condition score (BCS; 3.04 ± 0.06) and assigned to receive (SUPP; n = 18) or not (CON; n = 18) 30 g/cow daily (as-fed basis) of Actifor Pro (Delacon Biotechnik GmbH; Steyregg, Austria). From d 0 to 84, SUPP cows individually received (as-fed basis) 15 g of Actifor Pro mixed with 85 g of finely ground corn through self-locking headgates before each milking of the day. Each CON cow concurrently received 85 g (as-fed basis) of finely ground corn through self-locking headgates. Throughout the experimental period (d –7 to 84), cows from both treatments were administered 500 mg of sometribove zinc at 14-d intervals and were monitored daily for morbidity, including clinical mastitis. Individual milk production was recorded daily, whereas milk samples were collected weekly for analysis of milk composition. Cow BW, BCS, and blood samples were also collected weekly. Cows receiving SUPP gained more BCS (P = 0.05) and had greater (P = 0.04) milk yield during the experiment compared with CON cows (0.22 vs. 0.07 of BCS, SEM = 0.05; 29.5 vs. 27.9 kg/d, SEM = 0.5). Milk composition did not differ (P ≥ 0.15) between SUPP and CON cows; hence, SUPP cows also had greater (P ≤ 0.02) production of fat-corrected and energy-corrected milk. Incidence of clinical mastitis did not differ (P ≥ 0.49) between SUPP and CON cows. No treatment differences were also detected (P ≥ 0.21) for serum concentrations of glucose and serum urea N. Mean serum haptoglobin concentration during the experiment was greater (P = 0.05) in CON vs. SUPP cows. Cows receiving SUPP had less (P ≤ 0.04) serum cortisol concentrations on d 21 and 42, and greater (P ≤ 0.05) serum concentrations of insulin-like growth factor-I on d 7, 35, and 63 compared with CON cows (treatment × day interactions; P ≤ 0.02). Collectively, supplementing phytogenic feed ingredients improved nutritional status and milk production of lactating ¾ Holstein × ¼ Gir cows.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Productive and physiological responses of lactating dairy cows supplemented with phytogenic feed ingredients1

Rodrigues

Cooke

Firmino

et al. 2019

Translational Animal Science

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“…An article on homeopathic treatment of mastitis was recently published in the Journal of Dairy Science (Ebert et al, 2017). The results indicated no additional effect of homeopathic treatments compared with placebo.…”

Section: Natural Productsmentioning

confidence: 99%

A 100-Year Review: Metabolic modifiers in dairy cattle nutrition

McGuffey¹

2017

Journal of Dairy Science

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The first issue of the Journal of Dairy Science in 1917 opened with the text of the speech by Raymond A. Pearson, president of the Iowa State College of Agriculture, at the dedication of the new dairy building at the University of Nebraska (J. Dairy Sci. 1:4-18, 1917). Fittingly, this was the birth of a new research facility and more importantly, the beginning of a new journal devoted to the sciences of milk production and manufacture of products from milk. Metabolic modifiers of dairy cow metabolism enhance, change, or interfere with normal metabolic processes in the ruminant digestive tract or alter postabsorption partitioning of nutrients among body tissues. Papers on metabolic modifiers became more frequent in the journal around 1950. Dairy farming changed radically between 1955 and 1965. Changes in housing and feeding moved more cows outside, and cows and heifers in all stages of lactation, including the dry period, were fed as a single group. Rations became wetter with the shift to corn silage as the major forage in many rations. Liberal grain feeding met the requirements of high-producing cows and increased production per cow but introduced new challenges; for example, managing and feeding cows as a group. These changes led to the introduction of new strategies that identified and expanded the use of metabolic modifiers. Research was directed at characterizing the new problems for the dairy cow created by group feeding. Metabolic modifiers went beyond feeding the cow and included environmental and housing factors and additives to reduce the incidence and severity of many new conditions and pathologies. New collaborations began among dairy cattle specialties that broadened our understanding of the workings of the cow. The Journal of Dairy Science then and now plays an enormously important role in dissemination of the findings of dairy scientists worldwide that address existing and new technologies.

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“…The efficacy of antibiotic and/or anti-inflammatory treatment in mastitis is still a topic of scientific debate, and studies on treatment value in clinical cases show conflicting results [ 29 , 30 ]. Moreover, efforts to find other therapy methods such as homeopathic treatment had no success in this disease [ 31 ]. Identification of disease-causing genes that underlie complex traits such as susceptibility to mastitis is the goal of many genetic and biomedical studies, which provides mechanistic insights into host resistance in addition to improving the diagnosis and treatment of the disease.…”

Section: Introductionmentioning

confidence: 99%

Integration of machine learning and meta-analysis identifies the transcriptomic bio-signature of mastitis disease in cattle

et al. 2018

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Gram-negative bacteria such as Escherichia coli (E. coli) are assumed to be among the main agents that cause severe mastitis disease with clinical signs in dairy cattle. Rapid detection of this disease is so important in order to prevent transmission to other cows and helps to reduce inappropriate use of antibiotics. With the rapid progress in high-throughput technologies, and accumulation of various kinds of ‘-omics’ data in public repositories, there is an opportunity to retrieve, integrate, and reanalyze these resources to improve the diagnosis and treatment of different diseases and to provide mechanistic insights into host resistance in an efficient way. Meta-analysis is a relatively inexpensive option with good potential to increase the statistical power and generalizability of single-study analysis. In the current meta-analysis research, six microarray-based studies that investigate the transcriptome profile of mammary gland tissue after induced mastitis by E. coli infection were used. This meta-analysis not only reinforced the findings in individual studies, but also several novel terms including responses to hypoxia, response to drug, anti-apoptosis and positive regulation of transcription from RNA polymerase II promoter enriched by up-regulated genes. Finally, in order to identify the small sets of genes that are sufficiently informative in E. coli mastitis, the differentially expressed gene introduced by meta-analysis were prioritized by using ten different attribute weighting algorithms. Twelve meta-genes were detected by the majority of attribute weighting algorithms (with weight above 0.7) as most informative genes including CXCL8 (IL8), NFKBIZ, HP, ZC3H12A, PDE4B, CASP4, CXCL2, CCL20, GRO1(CXCL1), CFB, S100A9, and S100A8. Interestingly, the results have been demonstrated that all of these genes are the key genes in the immune response, inflammation or mastitis. The Decision tree models efficiently discovered the best combination of the meta-genes as bio-signature and confirmed that some of the top-ranked genes -ZC3H12A, CXCL2, GRO, CFB- as biomarkers for E. coli mastitis (with the accuracy 83% in average). This research properly indicated that by combination of two novel data mining tools, meta-analysis and machine learning, increased power to detect most informative genes that can help to improve the diagnosis and treatment strategies for E. coli associated with mastitis in cattle.

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Randomized, blinded, controlled clinical trial shows no benefit of homeopathic mastitis treatment in dairy cows

Cited by 12 publications

References 43 publications

Productive and physiological responses of lactating dairy cows supplemented with phytogenic feed ingredients1

Productive and physiological responses of lactating dairy cows supplemented with phytogenic feed ingredients1

A 100-Year Review: Metabolic modifiers in dairy cattle nutrition

Integration of machine learning and meta-analysis identifies the transcriptomic bio-signature of mastitis disease in cattle

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