Randomized and double-blinded pilot clinical study of the safety and anti-diabetic efficacy of the Rauvolfia-Citrus tea, as used in Nigerian Traditional Medicine

Campbell-Tofte, Joan; Mølgaard, Per; Josefsen, Knud; Abdallah, Zostam; Hansen, Steen Honoré; Cornett, Claus; Mu, Huiling; Richter, Erik A.; Petersen, Henning Willads; Nørregaard, Jens Christian; Winther, Kaj

doi:10.1016/j.jep.2010.10.013

Cited by 30 publications

(34 citation statements)

References 35 publications

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“…In a randomized, doubleblinded, and placebo-controlled pilot clinical trial, a 4-month administration of RC to Danish T2D patients already stabilized on OADs, led to significant reductions in postprandial plasma glucose and HbA1c values, without adverse effects or significant weight loss. 28 Although basal phosphorylated acetyl CoA carboxylase was significantly reduced with RC treatment, basal AMP-activated protein kinase expression was unaffected, suggesting that the treatment does not enhance beta-oxidation via AMPK activity. Neither treatment with RC tea nor the placebo caused changes in body weight in the study subjects.…”

Section: Finding Phytopreparations With Innovative and More Effectivementioning

confidence: 94%

“…and the Rauvolfia-Citrus decoction. 28 Within the last two decades, there has been a renaissance of interest in Western countries for treatment solutions known in local traditional medicine and considerable adoption of foreign traditional medicinal practices, particularly of Chinese and Ayurvedic origins. 19 Whether this phenomenon is driven by increased immigration or globalization, the WHO fact sheet No 134 also states that 70%-80% of the population in developed countries has used some form of alternative or complementary medicine.…”

Section: From Everywherementioning

confidence: 99%

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Harnessing the potential clinical use of medicinal plants as anti-diabetic agents

Campbell-Tofte¹,

Mølgaard²,

Winther³

2012

BTAT

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Diabetes is a metabolic disorder arising from complex interactions between multiple genetic and/or environmental factors. The characteristic high blood sugar levels result from either lack of the hormone insulin (type 1 diabetes, T1D), or because body tissues do not respond to the hormone (type 2 diabetes, T2D). T1D patients currently need exogenous insulin for life, while for T2D patients who do not respond to diet and exercise regimes, oral anti-diabetic drugs (OADs) and sometimes insulin are administered to help keep their blood glucose as normal as possible. As neither the administration of insulin nor OADs is curative, many patients develop tissue degenerative processes that result in life-threatening diabetes comorbidities. Several surveys of medicinal plants used as anti-diabetic agents amongst different peoples have been published. Some of this interest is driven by the ongoing diabetes pandemic coupled with the inadequacies associated with the current state of-the-art care and management of the syndrome. However, there is a huge cleft between traditional medicine and modern (Western) medicine, with the latter understandably demanding meaningful and scientific validation of anecdotal evidence for acceptance of the former. The main problems for clinical evaluation of medicinal plants with promising anti-diabetic properties reside both with the complexity of components of the plant materials and with the lack of full understanding of the diabetes disease etiology. This review is therefore focused on why research activities involving an integration of Systems Biology-based technologies of pharmacogenomics, metabolomics, and bioinformatics with standard clinical data, should be used for cost-effective validation of the safety and anti-diabetic efficacy of promising medicinal plants. The application of such approaches to studying entire mixtures of plant materials will ensure proper elucidation of novel therapies with improved mechanisms of action, as well as facilitate a personalized clinical use of medicinal plants as anti-diabetic agents.

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Section: Finding Phytopreparations With Innovative and More Effectivementioning

confidence: 94%

Section: From Everywherementioning

confidence: 99%

Harnessing the potential clinical use of medicinal plants as anti-diabetic agents

Campbell-Tofte¹,

Mølgaard²,

Winther³

2012

BTAT

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“…54 The African snake root/bitter orange tea is a traditional Nigerian remedy for DM. After 4 months, 2-hour postprandial plasma glucose levels fell significantly in the traditional versus the placebo tea group.…”

Section: English Walnut Leafmentioning

confidence: 99%

Herbs for Diabetes: Update—Part 2

Yarnell¹

2015

Alternative and Complementary Therapies

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This article continues a review of herbal medicines for diabetes mellitus (DM) begun in the prior issue of this Journal. The research on Momordica charantia (bitter melon) fruit for diabetes mellitus (DM) published since 2005 is reviewed. Vegetable insulin derived from the seeds of bitter melon is discussed. Research on, and use of, Opuntia spp. (prickly pear) fruit and pad for DM since 2000 is reviewed. A thorough discussion of Trigonella foenum-graecum (fenugreek) seed and Aloe vera (aloe) gel, both relatively well-studied agents, is included.Several less well-documented but intriguing herbal antidiabetics, including Capparis spinosa (capers) fruit, Juglans regia (English walnut) leaf, Rauvolfia vomitoria (African snakeroot) root, Citrus aurantium (bitter orange) peel, and Salvia officinalis (sage) leaf are reviewed.

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“…A combination of Epigallocatechin gallate (the main component of green tea extract) and amla (an extract from the Indian gooseberry) showed improvements in plasma glucose levels, LDL/HDL ratio, and measures of oxidative stress in patients with T2D and uremia [28•]; turmeric was found to lower urine protein and urinary IL-8 in patients with diabetic nephropathy [29]. Studies of Rauvolfiacitrus tea, a Nigerian folk medicine, [30], broccoli sprouts [31], almonds [32,33], and fractionated yellow pea flour [34] reported significant results in glycemic parameters, insulin resistance, lipids, or oxidative stress. Studies of tomatoes [35] and flaxseed/flaxseed oil [36] did not find statistically significant results (Table 2).…”

Section: Natural Productsmentioning

confidence: 99%

Complementary and Alternative Medicine in Diabetes Care

et al. 2012

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Growing numbers of people with diabetes in the U.S. and worldwide use complementary and alternative medicine (CAM) while receiving conventional medical therapy as a means of managing disease and improving quality of life. Although herbal and natural products are the most commonly used forms of CAM, mind-body approaches are also gaining popularity and scientific interest. Current findings suggest that CAM may help to promote an integrative, participatory model of diabetes care that relies upon provider knowledge of evidence-based therapies and patient disclosure of CAM use. Emerging evidence of positive findings with some natural products and mind-body therapies have been reported in glycemic parameters, markers of cardiovascular risk, and quality of life in individuals with type 2 diabetes; however, further investigation in well-designed, adequately powered studies is needed before use of CAM modalities can be recommended as part of clinical care.

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Randomized and double-blinded pilot clinical study of the safety and anti-diabetic efficacy of the Rauvolfia-Citrus tea, as used in Nigerian Traditional Medicine

Cited by 30 publications

References 35 publications

Harnessing the potential clinical use of medicinal plants as anti-diabetic agents

Harnessing the potential clinical use of medicinal plants as anti-diabetic agents

Herbs for Diabetes: Update—Part 2

Complementary and Alternative Medicine in Diabetes Care

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