2008
DOI: 10.1186/1471-244x-8-69
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Randomised trials relevant to mental health conducted in low and middle-income countries: a survey

Abstract: Background: A substantial proportion of the psychiatric burden of disease falls on the world's poorest nations, yet relatively little is known about randomised trials conducted in these countries. Our aim was to identify and describe a representative sample of mental health trials from low and middle-income countries.

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Cited by 16 publications
(12 citation statements)
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References 28 publications
(32 reference statements)
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“…Findings of significant improvement for people with a variety of mental health problems are consistent with other surveys in developing countries (Mari et al, 2009;Razzouk et al, 2010;Sheriff, Adams, Tharyan, Jayaram, & Duley, 2008). Comparative studies have actually demonstrated better long-term outcomes for schizophrenia in LMIC, particularly for individuals living in rural areas (Leff, Sartorius, Jablensky, Korten, & Ernberg, 1992).…”
Section: Overall Intervention Findingssupporting
confidence: 71%
“…Findings of significant improvement for people with a variety of mental health problems are consistent with other surveys in developing countries (Mari et al, 2009;Razzouk et al, 2010;Sheriff, Adams, Tharyan, Jayaram, & Duley, 2008). Comparative studies have actually demonstrated better long-term outcomes for schizophrenia in LMIC, particularly for individuals living in rural areas (Leff, Sartorius, Jablensky, Korten, & Ernberg, 1992).…”
Section: Overall Intervention Findingssupporting
confidence: 71%
“…A recent review has shown that 3% of clinical trials carried out in LAMIC were relevant to mental health, and they were conducted mostly in China [40]. Although there is an overall increase in the number of trials from these countries, they observed that, most of trials comprised of small samples with several methodological limitations [40].…”
Section: Discussionmentioning
confidence: 98%
“…A recent review has shown that 3% of clinical trials carried out in LAMIC were relevant to mental health, and they were conducted mostly in China [40]. Although there is an overall increase in the number of trials from these countries, they observed that, most of trials comprised of small samples with several methodological limitations [40]. We have also observed an increase in the number of clinical trials in mental health among leading Latin American countries in the period from 1999 to 2003, but we did not address the nature or quality of these trials [25].…”
Section: Discussionmentioning
confidence: 99%
“…However, to date we have little understanding of mental health outcomes among caregivers in these families. Our findings contribute insight into the intergenerational effects of HIV and violence on the mental health of families in South Africa, adding to the literature on the burden of mental health in low- and middle-income countries (68, 69). We still need to better understand how caregiver mental health may affect child outcomes through mechanisms such as parenting, family communication, and caregiver and child relationships.…”
Section: Discussionmentioning
confidence: 62%