Randomised trial of azithromycin to eradicate Ureaplasma in preterm infants

Gandecha, Hema; Boyle, Elaine M.

doi:10.1111/apa.16159

Cited by 1 publication

(1 citation statement)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, a recent randomized trial reported that the eradication of Ureaplasma by azithromycin failed to decrease the risk of BPD [ 12 ]. Although the trial was underpowered to detect a difference in BPD due to funding problems [ 13 ], it indirectly supports the idea that Ureaplasma was not associated with BPD [ 14 ]. Noticeably, the detection and diagnosis criteria of Ureaplasma and BPD vary greatly among these studies, which may partially explain the elusive association between Ureaplasma and BPD.…”

Section: Introductionmentioning

confidence: 93%

Association of Ureaplasma infection pattern and azithromycin treatment effect with bronchopulmonary dysplasia in Ureaplasma positive infants: a cohort study

et al. 2023

View full text Add to dashboard Cite

Background It is unclear whether Ureaplasma-associated pneumonia and azithromycin treatment affect the risk for bronchopulmonary dysplasia (BPD). Methods A retrospective cohort study was performed in very low birth weight (VLBW) infants who tested positive for Ureaplasma within 72 h after birth in a tertiary unit. Chest X-ray (CXR) and laboratory test were performed before and after azithromycin treatment. Multivariate logistic regression analysis was used to identify the independent association between BPD and Ureaplasma-associated pneumonia, as well as BPD and effective azithromycin treatment. Results A total of 118 infants were included in the current study, of whom 36 developed BPD (defined as supplemental oxygen needed at postmenstrual age 36 weeks or discharge). The rate of BPD was significantly higher in infants with Ureaplasma-associated pneumonia (44.6%) compared to infants with Ureaplasma colonization (17.7%, P = 0.002). After adjusting for confounders, an effective azithromycin treatment was significantly associated with reduced risk of BPD [odd ratio (OR) 0.011; 95% confidence interval (CI): 0.000–0.250), whereas Ureaplasma-associated pneumonia was not significantly associated with BPD (OR 1.835; 95% CI: 0.548–6.147). Conclusion Effective Azithromycin treatment in Ureaplasma positive VLBW infants was associated with a reduced risk of BPD.

show abstract

Section: Introductionmentioning

confidence: 93%