Randomised study on steroid free immunosuppression with basiliximab induction vs standard triple drug immunosuppression in adult live donor liver transplantation (LDLT). CTRI/2017/08/009508

Abstract

p=0.04), total bilirubin (p=0.03), TNF-alpha (p< 0.01), IL-10 (p< 0.01); and IL-6 (p< 0.01). Mitochondrial calcium retention capacity and respiration confirmed preservation of mitochondrial function in Group II. Histopathological evaluation of hepatocyte viability showed minimal ischemic changes in Group II; however, a significant degree of hepatocyte necrosis was observed the other groups. Conclusion: Ex Vivo subnormothermic regulated hepatic reperfusion mitigates IRI, preserves mitochondrial function and facilitates liver function recovery after donation after cardiac death. This novel strategy has potential applicability to human liver transplantation.