Randomised, placebo-controlled, double-blind clinical trial of β-sitosterol in patients with benign prostatic hyperplasia

Berges, Richard; Windeler, Jürgen; Trampisch, Hans–Joachim; Senge, Th.; group, β-sitosterol study

doi:10.1016/s0140-6736(95)91085-9

Cited by 263 publications

(143 citation statements)

References 9 publications

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“…8,16 Rückle was the first physician who regularly used tea from Urtica dioica in cases of urine retention. 17 Since these first observations, various extracts of Urtica dioica were commonly used in the treatment of prostate diseases.…”

Section: Discussionmentioning

confidence: 99%

“…21 In another clinical trial, β-sitosterol was found to significantly improve the symptoms and urinary flow of the patients. 8 Another component of Urtica dioica root extracts was shown to directly inhibit cell proliferation of HeLa cells and to block binding of epidermal growth factor (EGF) to its receptor. 22 All these observations need however further verifications since none of them has given satisfactory explanations.…”

Section: Discussionmentioning

confidence: 99%

“…7 For example, it has been observed that β-sitosterol which is rich in Urtica dioica causes significant improvement in symptoms and urinary flow parameters of patients with prostate diseases. 8 In fact, drugs derived from plants have a long tradition in the medical treatment of prostate diseases. Although neither mechanism of action nor precise classification of the active compounds for many of these drugs have yet been established, substantial symptom improvement has been reported.…”

Section: Introductionmentioning

confidence: 99%

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Aqueous extract of urtica dioica makes significant inhibition on adenosine deaminase activity in prostate tissue from patients with prostate cancer

Durak

Biri²,

Devrım³

et al. 2004

Cancer Biology & Therapy

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Aim: Investigation of possible effects of aqueous extract of Urtica dioica leaves on adenosine deaminase activity in prostate tissue from patients with prostate cancer.Methods: Ten prostate tissues from patients with pathologically proven localized prostate cancer (Gleason scores 4 to 7) were used in the study. In the tissues, ADA activities with and without preincubation with different amounts of Urtica dioica extracts were performed.Results: Aqueous extract of Urtica dioica results in significant inhibition on adenosine deaminase (ADA) activity of prostate tissue.Conclusion: ADA inhibition by Urtica dioica extract might be one of the mechanisms in the observed beneficial effect of Urtica dioica in prostate cancer.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Aqueous extract of urtica dioica makes significant inhibition on adenosine deaminase activity in prostate tissue from patients with prostate cancer

Durak

Biri²,

Devrım³

et al. 2004

Cancer Biology & Therapy

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“…4 ± 7 On the contrary, only a limited number of placebo-controlled studies concerning the ef®cacy of plant extracts using up-to-date methodology have been executed with b-sitosterol. 8,9 In addition, the ef®cacy of the phytotherapeutic Serenoa repens seems to be comparable to that of ®nasteride. 10 The fact, however, that this trial did not include a placebo group and that the ef®cacy of ®nasteride over placebo is questioned in patients with small prostates 3,7 makes these study results less convincing.…”

Section: Introductionmentioning

confidence: 99%

Treatment of lower urinary tract symptoms suggestive of benign prostatic obstruction in real life practice in France

Vallancien

Pariente

2001

Prostate Cancer Prostatic Dis

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The objective of this work is to describe the pro®le of prevalent and incident populations suffering from lower urinary tract symptoms (LUTS) suggestive of benign prostatic obstruction (BPO) and to analyse the management of care by 620 general practitioners (GPs) in France in 1997 and 1998. Patient records were extracted from the THALES database. Special attention was given to the use of medical therapy and switch rates (ie change to another or combination with another drug). In real life practice (RLP) French GPs predominantly utilise a 1 -adrenoceptor antagonists for the treatment of LUTS. This is in agreement with available evidence from randomised controlled trials (RCTs) with different medical therapies (a 1 -adrenoceptor antagonists, ®nasteride, plant extracts). On the contrary, the relatively high usage of phytotherapy might be explained by traditional and personal preferences. Using purely descriptive statistics, newer a 1 -adrenoceptor antagonists, alfuzosin and tamsulosin, seem to be the most frequently prescribed medical therapy for new patients and are, moreover, associated with a low switch rate. Prostate Cancer and Prostatic Diseases (2001) 4, 124±131.

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“…Moreover, the website mentions that the PSA levels in more than 70% of the patients decreased. In a placebo controlled survey of 200 men with benign prostate hypertrophy examining the substance beta-sitosterol, a component of Prostasol, it was reported that there were no significant side effects of beta-sitosterol and it was suggested that beta-sitosterol is a safe agent (Berges et al 1995 (Breza et al 1998). There is one published study that showed a suppression of testosterone upon intake of Prostasol and that effect was allocated to the presence of phytoestrogens (Clement and Bubley 2008).…”

Section: Examination Of the Supplementmentioning

confidence: 99%

Gynaecomastia linked to the intake of a herbal supplement fortified with diethylstilbestrol

Toorians

Bovee

Rooy

et al. 2010

Food Additives & Contaminants: Part A

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This study reports the findings of a supplement marketed on the internet for prostate problems. The supplement was orally taken by a 60-year old man with divergent hormonal levels and who was surgically treated for gynaecomastia: development of abnormally large mammary glands in males. The supplement showed a strong effect in a yeast estrogen bioassay, expressing a yeast enhanced green fluorescent protein (yEGFP) upon exposure to estrogens. Using both NMR and a gradient liquid chromatographic time of flight mass spectrometric (LC/TOFMS) method, the response was shown to be caused by very high levels of diethylstilbestrol, known for causing gynaecomastia. The gynaecomastia was most probably caused by this orally taken 'natural' herbal supplement, as the patient hormonal levels also returned to normal again when stopping the use of it. This case demonstrates that physicians need to be aware of the use of supplements with illegal components that may be responsible for unwanted side-effects.

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Randomised, placebo-controlled, double-blind clinical trial of β-sitosterol in patients with benign prostatic hyperplasia

Cited by 263 publications

References 9 publications

Aqueous extract of urtica dioica makes significant inhibition on adenosine deaminase activity in prostate tissue from patients with prostate cancer

Aqueous extract of urtica dioica makes significant inhibition on adenosine deaminase activity in prostate tissue from patients with prostate cancer

Treatment of lower urinary tract symptoms suggestive of benign prostatic obstruction in real life practice in France

Gynaecomastia linked to the intake of a herbal supplement fortified with diethylstilbestrol

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