“…Several biological mechanisms, including endogenous reproductive hormones, chronic inflammation and metabolic changes such as insulin resistance, have been proposed to explain the effects of adiposity and PA on BC prognosis (Calle & Kaaks, 2004;Champ, Volek, Siglin, Jin, & Simone, 2012;Neilson, Friedenreich, Brockton, & Millikan, 2009;Patterson et al, 2013). Several intervention studies have already been implemented to reach this goal (Befort et al, 2012;Fairey et al, 2003;Irwin et al, 2009;Lahart, Metsios, Nevill, Kitas, & Carmichael, 2016;Ligibel et al, 2008;Schmitz, Ahmed, Hannan, & Yee, 2005;Scott et al, 2013); nevertheless, due to the heterogeneity of their results, it is difficult to draw clear conclusions about the effects that lifestyle changes may have on lipid profiles, insulin resistance or adipokine levels. Studies in BC survivors have described a high prevalence of comorbid conditions in this population, which are likely to affect total mortality and also BC-specific mortality (Braithwaite et al, 2012;Nechuta et al, 2013;Patnaik, Byers, DiGuiseppi, Dabelea, & Denberg, 2011;.…”