Randomised controlled clinical trial for autologous fibroblast-hyaluronic acid complex in treating diabetic foot ulcers

You, Hi-Jin; Han, Seung Kyu; Rhie, Jong Won

doi:10.12968/jowc.2014.23.11.521

Cited by 42 publications

(52 citation statements)

References 22 publications

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“…The fibroblast is central to the normal wound-healing process [31]. Diabetes influences this process at the molecular level, resulting in fibroblast senescence and slower growth factor production [32]. Our results also demonstrated the impaired functions of diabetic fibroblasts.…”

Section: Discussionsupporting

confidence: 68%

Wound-healing potential of human umbilical cord blood–derived mesenchymal stromal cells in vitro—a pilot study

et al. 2015

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Section: Discussionsupporting

confidence: 68%

Wound-healing potential of human umbilical cord blood–derived mesenchymal stromal cells in vitro—a pilot study

et al. 2015

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“…El ECA de You, H.J. et al indicó que el complejo de ácido hialurónico-fibroblastos humanos autólogos puede ofrecer un tratamiento fiable para las DFU 15 , hecho que apoya a Dermagraft por contener fibroblastos y al ácido hialuróni-co como terapia tópica que ha demostrado tendencia a la curación 11 . El producto Targeted, como productor indirecto de liberación de colágeno mostró mejoras en la cicatrización de DFU 17 , sin embargo, de las terapias investigadas en la revisión sistemática del 2015, ninguna reveló evidencia suficiente 18 11,14 .…”

Section: Discussionunclassified

Tratamiento de úlceras en el pie diabético. Revisión

Blanco

2017

Rev. Int. Cienc. Podol.

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Resumen. La Diabetes Mellitus se postula como una de las grandes epidemias del siglo XXI, siendo el pie diabético una de sus mayores complicaciones. Objetivo: Describir tratamientos novedosos que permitan la cura de úlceras diabéticas. Metodología: Búsqueda de artículos publicados en Pubmed y Scielo y repaso de la bibliografía disponible en la Universidad Rey Juan Carlos hasta el 3 de enero de 2016. Resultados: Han sido revisados el estándar de cuidado, terapias electrofísicas como las ondas de choque, la presión negativa tópica, el ozono o el oxígeno hiperbárico, factores de crecimiento y equivalentes de piel biológica, entre otros, en un total de doce artículos. Discusión: La ozonoterapia, la corriente continua de baja intensidad catódica, los sustitutos de piel de bioingeniería, el complejo ácido hialurónico-fibroblastos autólogos y Targeted son terapias beneficiosas. Las ondas de choque, la presión negativa y el oxígeno hiperbárico recibieron bajo nivel de evidencia. Se recomienda el uso de factores de crecimiento endógenos por encima de los locales. Dermagraft aparece en confrontación entre artículos. El desbridamiento quirúrgico es el más eficaz, pero la terapia con larvas (desbridamiento biológico) cada vez tiene mayor peso. En descarga, la férula o yeso de contacto total y la férula o yeso de contacto total instantáneo resultaron ser útiles. Conclusiones: Los tratamientos existentes para las DFU son múltiples. No existe un protocolo específico de actuación, se debe ajustar el tratamiento al paciente. Son precisos más ensayos que generen resultados homogéneos y comparables entre estudios. Palabras clave: Úlcera de pie diabético; tratamiento; cuidado; terapia; cura.[en]Treatment of Diabetic foot Ulcers: A review Abstract. Mellitus diabetes has gained the tittle of epidemy of the 21 st century, in which the diabetic food is one its critics complication. Objective: To describe newfangled treatments which allow the cure of diabetic ulcerous. Methods: Research of articles published on "Pubmed" and "Scielo", as well as the review of the available bibliography on Rey Juan Carlos University unit January the 3 rd 2016. Results: They have been revised the following techniques: The care standards, electromechanical therapies, such as shock waves, topical negative pressure, ozone or hiperbaric oxygen; growing factors and biological skin equivalents, amongst others; out of twelve articles. Discussion: the therapy based on ozone, low cathodic continuous flow, bio-ingeniering skin substitutes, hialuronic-fibroblasts autolugous and Targeted are beneficial therapies. The shock waves, topical negative pressure and the hiperbaric oxygen received a low evidence level. The use of endogenous growing factors recommended above the locals. There is a confrontation in the articles about Dermagraft. Surgical debridement is the most efficient, but larval therapy (biological debridement) is become more relevant. In discharge, splint or total contact plaster and splint or instantaneous total contact plaster resulted useful. Conclusion...

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“…There was no difference in the numbers of patients healed at 12 weeks, but the study was stopped before the planned target of 200 patients was reached because of the long duration of recruitment (>6 years) . Another unblinded study of cultured autologous fibroblasts plus HA in 63 patients reported significant benefit on complete ulcer healing at 12 weeks but only included dorsal ulcers and was considered to be at a high risk of bias …”

Section: Bioengineered Skin and Skin Graftsmentioning

confidence: 99%

“…147 Another unblinded study of cultured autologous fibroblasts plus HA in 63 patients reported significant benefit on complete ulcer healing at 12 weeks but only included dorsal ulcers and was considered to be at a high risk of bias. 148…”

Section: Fibroblast/keratinocyte Co-culturementioning

confidence: 99%

Effectiveness of interventions to enhance healing of chronic foot ulcers in diabetes: a systematic review

Vas

Rayman

Dhatariya

et al. 2020

Diabetes Metabolism Res

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The management of diabetic foot ulcers (DFU) remains a challenge, and there is continuing uncertainty concerning optimal approaches to wound healing. The International Working Group of the Diabetic Foot (IWGDF) working group on wound healing has previously published systematic reviews of the evidence in 2008, 2012 and 2016 to inform protocols for routine care and to highlight areas which should be considered for further study. The working group has now updated this review by considering papers on the interventions to improve the healing of DFU's published between June 2014 and August 2018. Methodological quality of selected studies was independently assessed by a minimum of two reviewers using the recently published 21‐point questionnaire as recommended by IWGDF/European Wound Management Association, as well as the previously incorporated Scottish Intercollegiate Guidelines Network criteria. Of the 2275 papers identified, 97 were finally selected for grading following full text review. Overall, there has been an improvement in study design and a significant rise in the number of published studies. While previous systematic reviews did not find any evidence to justify the use of newer therapies, except for negative pressure wound therapy in post‐surgical wounds, in this review we found additional evidence to support some interventions including a sucrose‐octasulfate dressing, the combined leucocyte, fibrin and platelet patch as well as topical application of some placental membrane products, all when used in addition to usual best care. Nonetheless, the assessment and comparison of published trials remains difficult with marked clinical heterogeneity between studies: in patient selection, study duration, standard of usual care provision and the timing and description of the clinical endpoints.

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Randomised controlled clinical trial for autologous fibroblast-hyaluronic acid complex in treating diabetic foot ulcers

Abstract: These results indicate that autologous fibroblast-hyaluronic acid complex may offer a safe and effective treatment for DFUs.

Cited by 42 publications

References 22 publications

Wound-healing potential of human umbilical cord blood–derived mesenchymal stromal cells in vitro—a pilot study

Wound-healing potential of human umbilical cord blood–derived mesenchymal stromal cells in vitro—a pilot study

Tratamiento de úlceras en el pie diabético. Revisión

Effectiveness of interventions to enhance healing of chronic foot ulcers in diabetes: a systematic review

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