Randomised Controlled Clinical Study of Injection Caroverine and Ginkgo Biloba Extract in Cochlear Synaptic Tinnitus

Nishad, Rajeev Kumar; Jain, Anil K.; Singh, Magan; Verma, Reetu; Jain, Sanyogita

doi:10.1007/s12070-019-01655-5

Cited by 7 publications

(8 citation statements)

References 11 publications

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“…Furthermore, G. biloba extract EGb 761 had a lower rate of adverse events than its comparator pentoxifylline. This finding was supported by another parallel group RCT showing that 240 mg G biloba extract EGb 761 significantly improved self-perception of tinnitus loudness and severity after 90 days of treatment in patients with hearing loss (Procházková et al, 2018;Nishad et al, 2019;Radunz et al, 2020). In an earlier RCT of 60 patients with chronic tinnitus, Morgenstern and Biermann demonstrated that 160 mg/day G biloba extract EGb 761 subsequent to 10-day G. biloba extract EGb 761 infusion resulted in significant change in tinnitus volume compared to placebo (Morgenstern and Biermann, 2002).…”

Section: G Biloba In the Treatment Of Tinnitusmentioning

confidence: 73%

Herbal medicines in the treatment of tinnitus: An updated review

Hu²,

Wang³

et al. 2023

Front. Pharmacol.

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Tinnitus is perception of sound in the absence of an apparent external acoustic stimulus. The condition is prevalent in adults, especially the elderly (≥65 years), and may be associated with cognitive function decline and significantly impacts on the quality of life, heralding difficulties in managing this challenging disorder. Interventions for tinnitus have been varied. However, drugs have not yet been approved for the treatment of tinnitus and there is no pharmacotherapy recommended by existing guidelines. Still, herbal medicines are used for the treatment of tinnitus in many countries, especially Gingko (G.) biloba. In the current updated literature review, we evaluated the efficacy of herbal medicines in the treatment of tinnitus by reviewing the evidence of relevant randomized controlled trials. The authors also highlight some of the issues in clinical trials of herbal medicines given that currently available evidence on herbal medicines for tinnitus is overall of insufficient quality and the conclusions from existing trials are conflicting. Nevertheless, there is a clear and urgent need for safe and effective pharmacotherapy of tinnitus.

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Section: G Biloba In the Treatment Of Tinnitusmentioning

confidence: 73%

Herbal medicines in the treatment of tinnitus: An updated review

Hu²,

Wang³

et al. 2023

Front. Pharmacol.

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“…Procházková et al ( Procházková et al, 2018 ) in a recent double-blind randomized trial of 200 subjects with sub-chronic or chronic tinnitus who received either G. biloba Egb 761 extract or pentoxifylline over 12 weeks found significant improvement in all tinnitus questionnaires used. Nishad et al ( Nishad et al, 2019 ) evaluated the effect of treatment with a single intravenous injection of caroverine and G. biloba extract (60 mg twice a day) in 86 patients with tinnitus. They found that a single dose infusion of caroverine immediately improved tinnitus in 54.5% of the patients, but the improvement was not sustained at a 3-6 months follow-up.…”

Section: Discussionmentioning

confidence: 99%

The effect of MemoVigor 2 on recent-onset idiopathic tinnitus: a randomized double-blind placebo-controlled clinical trial

Balatsouras,

Papitsi,

Koukoutsis

et al. 2024

Front. Pharmacol.

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Background: Tinnitus is a common symptom associated with the conscious perception of sound in the absence of a corresponding external or internal sound source, which can severely impact quality of life. Because of the current limited understanding of the precise pathophysiological mechanism of idiopathic tinnitus, no curable treatment has been attained yet. A food supplement trading as MemoVigor 2, which contains a combination of therapeutic ingredients with mainly antioxidant activity, has been used in the treatment of tinnitus. The objective of our study was to evaluate the effectiveness of MemoVigor 2 in the treatment of recent-onset idiopathic tinnitus.Methods: In a prospective single-centre randomized, double-blind, placebo-controlled clinical trial we studied 204 patients with idiopathic tinnitus divided into two groups: 104 patients who received MemoVigor 2 and 100 patients treated with placebo. To evaluate changes in tinnitus we used (1) audiometry/tympanometry; (2) specific measures of tinnitus perception, including tinnitus pitch, loudness at tinnitus pitch, loudness at 1 kHz, minimum masking level, and residual inhibition; (3) questionnaires of tinnitus handicap inventory, mini tinnitus questionnaire and patients’ global impression of change. All patients underwent this test battery at the beginning of the study and in a repeat post-3-month session.Results: All tinnitus measures, including pitch, loudness, minimum masking level and residual inhibition improved significantly in the intervention group. Most of these measures improved in the placebo group too, but in a lesser degree. All questionnaire scores diminished significantly in both groups, but the degree of decrease was greater in the intervention group. The participants’ tinnitus outcome reported after treatment using the patients’ global impression of change score differed significantly between the two groups, with greater improvement observed in the intervention group.Conclusion: We found that the use of MemoVigor 2 improved recent-onset tinnitus, as proved by a set of tests performed for its evaluation, including audiometric measures, specific measures of tinnitus perception and tinnitus questionnaires. Tinnitus in the placebo group improved too, but to a lesser degree.Clinical Trial Registration: isrctn.com, Identifier ISRCTN16025480

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“…The yearly trend in major drug prescriptions has been decreasing for blood circulation agents and increasing for tinnitus agents and vertigo agents. The main ingredient in tinnitus agents is Ginkgo biloba, which is a CAM drug that research suggests is effective in treating tinnitus [ 35 , 36 ]. Moreover, because Ginkgo biloba is used to treat tinnitus, it can also be classified as a vasodilator [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

Trends of Medical Service Utilization for Tinnitus: Analysis Using 2010–2018 Health Insurance Review and Assessment Service National Patient Sample Data

et al. 2022

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Given the increasing prevalence of tinnitus and expenditure related to its treatment, it is important to identify the efficacy of different treatment methods used for its diagnosis and treatment. To this end, this study analyzed the trends of medical service utilization for tinnitus in adult patients from 2010 to 2018 based on a national sample of medical claims data from the Health Insurance Review and Assessment Service National Patient Samples database. A total of 94,323 patients with tinnitus were identified in Korea between 2010 and 2018. The results confirmed that the number of patients, claim numbers, and expenditures steadily increased during the nine-year period. Blood circulation agents were the most commonly used drug therapy; however, the frequency of their use gradually decreased, whereas that of tinnitus and vertigo medicines gradually increased. Total and average expenditure per patient nearly doubled in this period. The study showed that medication trends are changing from blood circulation agents to tinnitus or vertigo medicines. The findings of this study may be helpful for clinicians and researchers in the study, treatment, and management of tinnitus.

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Randomised Controlled Clinical Study of Injection Caroverine and Ginkgo Biloba Extract in Cochlear Synaptic Tinnitus

Cited by 7 publications

References 11 publications

Herbal medicines in the treatment of tinnitus: An updated review

Herbal medicines in the treatment of tinnitus: An updated review

The effect of MemoVigor 2 on recent-onset idiopathic tinnitus: a randomized double-blind placebo-controlled clinical trial

Trends of Medical Service Utilization for Tinnitus: Analysis Using 2010–2018 Health Insurance Review and Assessment Service National Patient Sample Data

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