Randomised comparison of the FerX Ella antireflux stent and the ultraflex stent: Proton pump inhibitor combination for prevention of post‐stent reflux in patients with esophageal carcinoma involving the esophago‐gastric junction

Abstract

The antireflux stent had no demonstrable advantages compared to the combination of standard open stent and proton pump inhibitor medication.

The Use of Self-Expanding Stents in Esophageal and Gastroesophageal Junction Cancer Palliation: A Meta-Analysis and Meta-Regression Analysis of Outcomes

“…Two studies had a score of 4 points [6,7], eight studies had scores of 3 [4,8,10,12,[14][15][16]18], five studies scored 2 [3,9,11,13,17], and one study received one point [5]. The baseline characteristics of the patients in the trials included are summarized in Table 2.…”

“…All randomized control trials (RCTs) concerning esophageal and gastroesophageal junction palliation were identified [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18]. Studies using the conventional prosthetic tubes (Celestin or Mackler tube) were excluded since the method has fallen out of favor.…”

Technical feasibility and safety of a new, implantable reflux control system to prevent gastroesophageal reflux in patients with stents placed through the lower esophageal sphincter (with video)

“…11,14 In addition, most patients with a stent placed across the GEJ are effectively treated with a standard open stent in combination with PPI therapy. 5 In the small selection of patients who experience persistent reflux symptoms despite PPI use, an implantable anti-reflux valve may be an option.…”

“…4 In the last decade, various anti-reflux stent designs have been tested in patients with distal esophageal cancer. [4][5][6][7][8][9][10][11] Clinical success with regard to relief of dysphagia and reflux symptoms, however, varies considerably between stent designs. Because some anti-reflux stents are associated with high migration rates, 4 it is not generally recommended to place anti-reflux stents in all patients with GEJ cancer.…”

Gastrointestinal stenting: Current status and imaging features

“…Although some of the stents appeared effective in reducing gastroesophageal reflux, further research is required to confirm this favorable outcome [29][30][31][32][33][34]. During the start of radiotherapy, dysphagia often increases due to mucositis and esophagitis.…”