Randomised clinical trial: rabeprazole improves symptoms in patients with functional dyspepsia in Japan

Iwakiri, Ryuichi; Tominaga, Kazunari; Furuta, K.; Inamori, Masahiko; Furuta, Takahisa; Masuyama, Hironori; Kanke, Kazunari; Nagahara, Akihito; Haruma, Ken; Kinoshita, Yoshikazu; Higuchi, Kazuhide; Takahashi, S.; Kusano, Motoyasu; Iwakiri, Katsuhiko; Kato, Mototsugu; Hongo, Michio; Hiraishi, Hideyuki; Watanabe, Sumio; Miwa, Hiroto; Naito, Yuji; Fujimoto, Kazuma; Arakawa, Tetsuo

doi:10.1111/apt.12444

Cited by 63 publications

(71 citation statements)

References 29 publications

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“…The lesser number of subjects with gastroduodenal ulcers might be a major reason for the lack of a relationship between gastroduodenal ulcers and upper gastrointestinal symptoms. The presence of relationship between H. pylori infection and dyspepsia symptoms was controversial in several studies [20][21][22] , and this study suggests that H. pylori infection does not influence the development of acid-related dyspepsia in the general population of Japan.…”

Section: Discussionmentioning

confidence: 72%

Higher Frequency of Reflux Symptoms and Acid-Related Dyspepsia in Women than Men Regardless of Endoscopic Esophagitis: Analysis of 3,505 Japanese Subjects Undergoing Medical Health Checkups

Takeshita

Sakata²,

Hara³

et al. 2016

Digestion

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Background/Aims: This study aimed at (i) clarifying the factors associated with high scores on the modified frequency scale for the symptoms of gastroesophageal reflux disease (FSSG) among 3,505 relatively healthy subjects undergoing routine medical health checkups with gastrointestinal endoscopy and (ii) comparing risk factors for high FSSG scores between subjects with and without reflux esophagitis. Methods: In total, 3,505 subjects (male/female: 1,922/1,583) who underwent upper gastrointestinal endoscopy during health medical checkups at 5 hospitals in Saga, Japan from January 2013 to December 2013 were enrolled. All subjects completed a modified FSSG questionnaire, which comprised 7 questions regarding reflux symptoms and 7 questions regarding acid-related dyspepsia. Each question was assigned a score based on the frequency of symptoms. Results: Younger age, female gender, hiatal herniation, and endoscopic reflux esophagitis were risk factors for a FSSG score with a high total. Subjects with high scores but without esophagitis were women, and hiatal herniation and Barrett's esophagus were frequently seen in patients with reflux esophagitis. Conclusion: Younger age, female gender, hiatal hernia, and endoscopic esophagitis were risk factors for a high FSSG score, and women tended to complain of upper gastrointestinal symptoms more frequently than did men among subjects without endoscopic esophagitis.

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Section: Discussionmentioning

confidence: 72%

Higher Frequency of Reflux Symptoms and Acid-Related Dyspepsia in Women than Men Regardless of Endoscopic Esophagitis: Analysis of 3,505 Japanese Subjects Undergoing Medical Health Checkups

Takeshita

Sakata²,

Hara³

et al. 2016

Digestion

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“…Participants rated the severity of symptoms (heartburn, epigastric pain, epigastric burning, postprandial fullness, epigastric bloating, early satiety, belching, nausea, abdominal bloating, and reflex feeling of gastric acid) occurring in the prior week on a 7-point Likert scale as follows [23,24]: (1) none (absence of symptoms); (2) extremely mild (symptoms could be entirely ignored); (3) mild (symptoms easily tolerated); (4) moderate (symptoms noticed by the patient, but did not affect daily activities); (5) moderate-to-severe (symptoms occasionally limited daily activities); (6) severe (symptoms often limited daily activities); and (7) extremely severe (considerable interference with daily activities, often requiring rest).…”

Section: Methodsmentioning

confidence: 99%

“…The elimination rate for the 4 major FD symptoms [24] was calculated for each group using the following formula: the number of participants who experienced the disappearance of symptoms / the number of participants in the group × 100. The elimination rate for PDS symptoms was calculated for each group using the following formula: the number of participants classified as PDS (during the baseline period) who experienced the simultaneous disappearance of postprandial fullness and early satiety / the number of participants classified as PDS (during the baseline period) in the group × 100.…”

Section: Methodsmentioning

confidence: 99%

The Ameliorating Effect of Lactobacillus gasseri OLL2716 on Functional Dyspepsia in Helicobacter pylori-Uninfected Individuals: A Randomized Controlled Study

Ohtsu

Takagi²,

Uemura

et al. 2017

Digestion

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Background/Aims: Probiotics appear to improve Helicobacter pylori-associated dyspepsia via an inhibitory effect on H. pylori; however, uncertainty exists regarding their effects in H. pylori-uninfected individuals. We evaluated the efficacy of Lactobacillus gasseri OLL2716 (L. gasseri OLL2716) on H. pylori-uninfected individuals with functional dyspepsia (FD). Methods: A double-blind, parallel-group, placebo-controlled, randomized, controlled trial was performed. Participants were randomly assigned to ingest L. gasseri OLL2716-containing yogurt (L. gasseri OLL2716 group) or L. gasseri OLL2716-free yogurt (placebo group) for 12 weeks. Participants completed questionnaires that dealt with a global assessment as well as symptom severity. The per-protocol (PP) population was evaluated for efficacy in accordance with a plan prepared beforehand. Results: Randomization was performed on 116 individuals; the PP population consisted of 106 individuals (mean age 42.8 ± 9.0). The impressions regarding the overall effect on gastric symptoms were more positive in the L. gasseri OLL2716 group compared to that in the placebo group (statistical trend; p = 0.073). The elimination rate for major FD symptoms was 17.3 and 35.3% in the placebo and L. gasseri OLL2716 groups respectively (p = 0.048). Conclusion:L. gasseri OLL2716 has beneficial effects on FD without H. pylori involvement.

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“…12 However, a recent trial conducted in Japan that confirmed the efficacy of the PPI rabeprazole in patients with functional dyspepsia did not show any difference in the effect of treatment according to whether patients met the criteria for the epigastric pain syndrome or the postprandial distress syndrome. 57 A trial of acid suppression seems to be a worthwhile strategy in most patients with functional dyspepsia, particularly in those who have negative results on H. pylori testing or in those with positive results on H. pylori testing in whom eradication therapy has not improved symptoms. Antacids, bismuth, and sucralfate are not efficacious in functional dyspepsia.…”

Section: Acid-suppression Therapymentioning

confidence: 99%

Functional Dyspepsia

2015

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Randomised clinical trial: rabeprazole improves symptoms in patients with functional dyspepsia in Japan

Abstract: SUMMARY BackgroundThe efficacy of proton pump inhibitors (PPIs) for treating functional dyspepsia (FD) is not well established.

Cited by 63 publications

References 29 publications

Higher Frequency of Reflux Symptoms and Acid-Related Dyspepsia in Women than Men Regardless of Endoscopic Esophagitis: Analysis of 3,505 Japanese Subjects Undergoing Medical Health Checkups

Higher Frequency of Reflux Symptoms and Acid-Related Dyspepsia in Women than Men Regardless of Endoscopic Esophagitis: Analysis of 3,505 Japanese Subjects Undergoing Medical Health Checkups

The Ameliorating Effect of Lactobacillus gasseri OLL2716 on Functional Dyspepsia in Helicobacter pylori-Uninfected Individuals: A Randomized Controlled Study

Functional Dyspepsia

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