Randomised clinical trial: an assessment of acupuncture on specific meridian or specific acupoint vs. sham acupuncture for treating functional dyspepsia

T., T.; Yu, Shu-Guang; Li, Ying; Liang, Fanrong; Tian, Xiaoping; Zheng, Hui; Yan, Jie; Sun, Guangling; Chang, Xiao-Rong; Zhao, Ling; Wu, Xi; Zeng, Fang

doi:10.1111/j.1365-2036.2011.04979.x

Cited by 156 publications

(116 citation statements)

References 30 publications

(34 reference statements)

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“…The strengths and limitations of our trial have been discussed in a recent article of our research group [15.] In sum, we have demonstrated that acupuncture, especially at the specific acupoints along the stomach meridian, was shown to be significantly more effective than sham acupuncture in relieving meal-related symptoms in PDS, mostly by improving postprandial fullness.…”

Section: Discussionmentioning

confidence: 91%

“…The study was conducted according to methods described in a previously conducted RCT [15 ]which was performed at the outpatient departments of 8 hospitals in China between April 2008 and October 2009 in compliance with the rules specified in the Declaration of Helsinki and the Good Clinical Practice Guidelines. The study consisted of a 7-day run-in period prior to randomization, a treatment period of 4 weeks (5 consecutive sessions per week with an interval of 2 days between 2 weeks), and a 12-week follow-up.…”

Section: Methodsmentioning

confidence: 99%

“…In our previous studies, we have demonstrated the therapeutic effect of acupuncture in treating FD by a large-sample randomized trial, in which itopride and non-acupoint acupuncture were used as positive and negative controls [15.] Further, we explored the biological effects and cerebral glycometabolic responses elicited by acupuncture by using metabonomic and neuroimaging approaches [16,17.]…”

Section: Introductionmentioning

confidence: 99%

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Which Subtype of Functional Dyspepsia Patients Responses Better to Acupuncture? A Retrospective Analysis of a Randomized Controlled Trial

Ma¹,

Zeng²,

Li³

et al. 2015

Complement Med Res

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Background: Whether subgroups of functional dyspepsia (FD) should be treated with different approaches is controversially discussed in research. As our previous study has demonstrated the effect of acupuncture in FD treatment, we now further analyze the therapeutic effect of acupuncture in the treatment of postprandial distress syndrome (PDS) and epigastric pain syndrome (EPS). Methods: A retrospective analysis was conducted in 465 eligible PDS patients and 241 EPS patients. 4 acupuncture groups (group A: specific acupoints along the stomach meridian; group B: non-specific acupoints along the stomach meridian; group C: alarm and transport acupoints; group D: specific acupoints along the gallbladder meridian) were compared with a non-acupoint sham acupuncture group and an itopride group. The patients were treated in 5 consecutive sessions per week for 4 weeks and were followed-up for 12 weeks afterwards. Primary outcome of the study was defined as response rate and symptom improvement as measured by the Symptom Index of Dyspepsia, while secondary outcome was designated as improvement in quality of life (QoL) as determined by the Nepean Dyspepsia Index. Results: Symptoms of dyspepsia and QoL were improved from baseline in all groups. In EPS patients, no statistically significant differences could be observed in response rate (p = 0.239) and symptoms improvement (p = 0.344 for epigastric pain; p = 0.465 for epigastric burning). In contrast, PDS patients of the acupuncture group A showed higher response rate (53.2% vs. 19.7%, p<0.001; 53.2% vs. 35.1%, p = 0.025) and score change in postprandial fullness (1.01 vs. 0.27, p<0.001; 1.01 vs. 0.57, p<0.001), early satiation (0.81 vs. 0.21, p<0.001; 0.81 vs. 0.39, p=0.001), and QoL (14.5 vs. 4.33, p<0.001; 14.5 vs. 8.5, p<0.001) compared to the sham acupuncture and itopride group. Conclusions: FD patients with PDS responded better to the acupuncture therapies, especially at the specific acupoints along the stomach meridian. The positive therapeutic effect of acupuncture on PDS was correlated with the improvement in postprandial fullness. Trial Registration: ClinicalTrial.gov NCT00599677.

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Section: Discussionmentioning

confidence: 91%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Which Subtype of Functional Dyspepsia Patients Responses Better to Acupuncture? A Retrospective Analysis of a Randomized Controlled Trial

Ma¹,

Zeng²,

Li³

et al. 2015

Complement Med Res

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“…External application of mirabilite on the abdomen can withdraw the ascites, ease the burden of abdominal distension and intestinal tract, promote the detumescence of enterocoelia swollen organs, and is beneficial to the control of inflammation and recovery of intestinal functions [18]. Acupuncture at acupoints of Stomach Meridian of Foot-Yangming has some effects including regulating spleen and stomach, invigorating spleen-reinforcing Qi, clearing and activating the channels and collaterals, strengthening body resistance and eliminating evil, dual-direction regulation of nerve-internal secretion-immune systems, inhibition of systemic inflammatory response, and few adverse reactions [19]. A previous study showed that acupuncture at ST36 and EA could improve the intestinal mucosal barrier in sepsis [13].…”

Section: Discussionmentioning

confidence: 99%

Early Traditional Chinese Medicine Bundle Therapy for the Prevention of Sepsis Acute Gastrointestinal Injury in Patients with Severe Sepsis

Jiang¹

2017

IJCAM

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To study the role of early traditional Chinese medicine bundle therapy on the prevention of sepsis-associated acute gastrointestinal injury (AGI). This was a multicenter, prospective cohort study of 296 consecutive patients with severe sepsis between 2013/3 and 2014/11; 150 patients received standard treatments (controls) and 146 received traditional Chinese medicine bundle therapy (intervention group) (herbal decoction gavage based on syndrome differentiation, acupuncture, application of mirabilite, and defecation mixture). D-lactic acid, diamine oxidase, endotoxin, gastrin, and intra-abdominal pressure were measured. AGI was classified into four levels. Compared with controls, D-lactic acid, diamine oxidase, endotoxin, gastrin, and intra-abdominal pressure in the intervention group were decreased and motilin was increased on day 7 (P<0.05). AGI incidence in the intervention group was lower than in controls (P<0.05). GIF scores of the intervention AGI II and III groups were lower than in controls (P<0.05). The APACHE II scores of intervention AGI II, III, and IV groups were lower than in controls (P<0.05). Compared with controls, mechanical ventilation time and ICU stay in the intervention group were shorter ( P=0.011 and P=0.035); and 28-day overall and AGI-attributed mortality were lower (P=0.048 and P=0.043). For patients with severe sepsis, early traditional Chinese medicine bundle therapy could decrease AGI incidence and improve prognosis.

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“…We read the commentary from Oh and Fass and appreciate their opinions on our study. 1,2 In our study, the sham acupuncture (superficial needling on non-acupoints) also provided an active therapeutic effect, but was significantly inferior to the acupuncture groups A, B, C in terms of improvement in symptoms and quality of life. Whether sham acupuncture is as effective as real acupuncture is still under debate, but more and more clinical trials [3][4][5] and brain image studies [6][7][8] in recent years have given the affirmative answer.…”

mentioning

confidence: 93%

Commentary: functional dyspepsia ‐ is acupuncture the solution?

Fass

2012

Aliment Pharmacol Ther

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Commentary: functional dyspepsia -is acupuncture the solution?We read the article published by Ma et al.1 with great interest. The authors concluded that acupuncture is effective in the treatment of functional dyspepsia using specific acupoints. The last decade has seen a growing interest in complementary and alternative medicine techniques, especially among patients with chronic medical disorders. 2Acupuncture has been utilised in various gastrointestinal disorders, demonstrating a significant effect on acid secretion, gastrointestinal motility, neurohormonal levels and sensory perception thresholds for pain. 3, 4The study by Ma and colleagues emphasises the importance of sticking to specific acupoints, which are related to the stomach meridian, when treating patients with functional dyspepsia. Overall, the acupuncture effect was most prominent in early satiation, although some effect was also observed in postprandial fullness, epigastric pain and burning. The authors did not embark on functional assessment of the oesophagus and stomach, and thus the underlying mechanism of symptom improvement in this study is unknown.Surprisingly, sham acupuncture in this study was significantly inferior to the other acupuncture groups, regardless of the specific acupoints. There is increasing recognition in the acupuncture literature that superficial (needling of the skin), sham (needling on non-acupuncture points) and placebo (needling with blunt tip that does not penetrate the skin) acupuncture also provides an active therapeutic effect.5 This is particularly the case in pain conditions that are predominantly associated with an affective component. 6 It is likely that control procedures used in many acupuncture studies aimed at being inert may activate the C tactile afferents that alleviate unpleasantness and re-establish patients' sense of well being. 5Because functional dyspepsia is a chronic disorder with exacerbations and remissions, it remains to be elucidated how long the acupuncture treatment should last and what is the durability of its effect. ACKNOWLEDGEMENTDeclaration of personal and funding interests: None.

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Randomised clinical trial: an assessment of acupuncture on specific meridian or specific acupoint vs. sham acupuncture for treating functional dyspepsia

Abstract: SUMMARY BackgroundFunctional dyspepsia (FD) is a common disease without an established optimal treatment.

Cited by 156 publications

References 30 publications

Which Subtype of Functional Dyspepsia Patients Responses Better to Acupuncture? A Retrospective Analysis of a Randomized Controlled Trial

Which Subtype of Functional Dyspepsia Patients Responses Better to Acupuncture? A Retrospective Analysis of a Randomized Controlled Trial

Early Traditional Chinese Medicine Bundle Therapy for the Prevention of Sepsis Acute Gastrointestinal Injury in Patients with Severe Sepsis

Commentary: functional dyspepsia ‐ is acupuncture the solution?

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