Abstract:In geriatric health care centres in France, an active multicenter program giving personal satisfaction and taking into account the profile of non-vaccinated HCWs was more effective in promoting flu vaccination than a scientifically factual information program. HCW involvement is required in program implementation in order to avoid rejection of top-down information.
“…Publication years ranged from 1992 to 2015. Most studies were BnA without a control group, [27][28][29][30][31][32][33][38][39][40][42][43][44][45][46]48 43,56 Five studies 35,41,54,58,71 evaluated separately more than one intervention on the same population or using the same controls, and 2 studies 27,28 were also performed on the same population. In two studies, 34,42 the same intervention was evaluated in independent populations or settings.…”
Section: Resultsmentioning
confidence: 99%
“…Regarding the risk of bias, out of the 11 RCTs or cRCTs, in 7 the method of randomization was unclear, 26,34,35,51,53,58,64 and one study employed a factorial design with partial randomization. 41 Allocation concealment in the 2 RCTs was unclear, 35,53 5 studies did not report vaccination coverage at baseline for the intervention and control groups, 34,35,37,47,53 and 9 studies (including the 3 controlled BnA studies) did not sufficiently report on potential baseline imbalances.…”
Section: Resultsmentioning
confidence: 99%
“…41 Allocation concealment in the 2 RCTs was unclear, 35,53 5 studies did not report vaccination coverage at baseline for the intervention and control groups, 34,35,37,47,53 and 9 studies (including the 3 controlled BnA studies) did not sufficiently report on potential baseline imbalances. 34 26,41,47,49,58 and in 3 of them the response rate was low enough to potentially bias the results. 41,47,58 Most studies offered vaccination in-house and could objectively ascertain vaccine coverage 26,35,36,49,53,64,68,71 ; one study used an external occupational health service, 37 another used general practitioner claim forms, 34 3 studies used self-report via quesionnaires to ascertain vaccination, 41,47,58 and one study did not report the method of ascertainment.…”
Section: Resultsmentioning
confidence: 99%
“…34 26,41,47,49,58 and in 3 of them the response rate was low enough to potentially bias the results. 41,47,58 Most studies offered vaccination in-house and could objectively ascertain vaccine coverage 26,35,36,49,53,64,68,71 ; one study used an external occupational health service, 37 another used general practitioner claim forms, 34 3 studies used self-report via quesionnaires to ascertain vaccination, 41,47,58 and one study did not report the method of ascertainment. 51 Of the uncontrolled BnA studies, none described particular concurrent events that could influence the post-intervention vaccination coverage, except in the 2 studies that reported a vaccine shortage during the previous year 43,56 ; although in these the comparison was made with the second-to-last year, the shortage might still have biased the post-intervention vaccination coverage.…”
Influenza vaccination is recommended for healthcare workers (HCWs), but coverage is often low. We reviewed studies evaluating interventions to increase seasonal influenza vaccination coverage in HCWs, including a meta-regression analysis to quantify the effect of each component. Fourty-six eligible studies were identified. Domains conferring a high risk of bias were identified in most studies. Mandatory vaccination was the most effective intervention component (Risk Ratio of being unvaccinated [RR unvacc ] D 0.18, 95% CI: 0.08-0.45), followed by "soft" mandates such as declination statements (RR unvacc D 0.64, 95% CI: 0.45-0.92), increased awareness (RR unvacc D 0.83, 95% CI: 0.71-0.97) and increased access (RR unvacc D 0.88, 95% CI: 0.78-1.00). For incentives the difference was not significant, while for education no effect was observed. Heterogeneity was substantial (t 2 D 0.083). These results indicate that effective alternatives to mandatory HCWs influenza vaccination do exist, and need to be further explored in future studies.
“…Publication years ranged from 1992 to 2015. Most studies were BnA without a control group, [27][28][29][30][31][32][33][38][39][40][42][43][44][45][46]48 43,56 Five studies 35,41,54,58,71 evaluated separately more than one intervention on the same population or using the same controls, and 2 studies 27,28 were also performed on the same population. In two studies, 34,42 the same intervention was evaluated in independent populations or settings.…”
Section: Resultsmentioning
confidence: 99%
“…Regarding the risk of bias, out of the 11 RCTs or cRCTs, in 7 the method of randomization was unclear, 26,34,35,51,53,58,64 and one study employed a factorial design with partial randomization. 41 Allocation concealment in the 2 RCTs was unclear, 35,53 5 studies did not report vaccination coverage at baseline for the intervention and control groups, 34,35,37,47,53 and 9 studies (including the 3 controlled BnA studies) did not sufficiently report on potential baseline imbalances.…”
Section: Resultsmentioning
confidence: 99%
“…41 Allocation concealment in the 2 RCTs was unclear, 35,53 5 studies did not report vaccination coverage at baseline for the intervention and control groups, 34,35,37,47,53 and 9 studies (including the 3 controlled BnA studies) did not sufficiently report on potential baseline imbalances. 34 26,41,47,49,58 and in 3 of them the response rate was low enough to potentially bias the results. 41,47,58 Most studies offered vaccination in-house and could objectively ascertain vaccine coverage 26,35,36,49,53,64,68,71 ; one study used an external occupational health service, 37 another used general practitioner claim forms, 34 3 studies used self-report via quesionnaires to ascertain vaccination, 41,47,58 and one study did not report the method of ascertainment.…”
Section: Resultsmentioning
confidence: 99%
“…34 26,41,47,49,58 and in 3 of them the response rate was low enough to potentially bias the results. 41,47,58 Most studies offered vaccination in-house and could objectively ascertain vaccine coverage 26,35,36,49,53,64,68,71 ; one study used an external occupational health service, 37 another used general practitioner claim forms, 34 3 studies used self-report via quesionnaires to ascertain vaccination, 41,47,58 and one study did not report the method of ascertainment. 51 Of the uncontrolled BnA studies, none described particular concurrent events that could influence the post-intervention vaccination coverage, except in the 2 studies that reported a vaccine shortage during the previous year 43,56 ; although in these the comparison was made with the second-to-last year, the shortage might still have biased the post-intervention vaccination coverage.…”
Influenza vaccination is recommended for healthcare workers (HCWs), but coverage is often low. We reviewed studies evaluating interventions to increase seasonal influenza vaccination coverage in HCWs, including a meta-regression analysis to quantify the effect of each component. Fourty-six eligible studies were identified. Domains conferring a high risk of bias were identified in most studies. Mandatory vaccination was the most effective intervention component (Risk Ratio of being unvaccinated [RR unvacc ] D 0.18, 95% CI: 0.08-0.45), followed by "soft" mandates such as declination statements (RR unvacc D 0.64, 95% CI: 0.45-0.92), increased awareness (RR unvacc D 0.83, 95% CI: 0.71-0.97) and increased access (RR unvacc D 0.88, 95% CI: 0.78-1.00). For incentives the difference was not significant, while for education no effect was observed. Heterogeneity was substantial (t 2 D 0.083). These results indicate that effective alternatives to mandatory HCWs influenza vaccination do exist, and need to be further explored in future studies.
“…Several randomised trials [85] have successfully used a pre-intervention survey as a basis for subsequent intervention mapping [25] , [86] in the development of multi-faceted interventions. This is particularly important as the reasons for vaccine hesitancy are complex and heterogeneous [52] , making local, social, cultural, institutional and logistical factors all relevant to the development of educational or knowledge-based interventions.…”
Introduction
The World Health Organization recommends vaccination of health workers (HWs) against influenza, but low uptake is intransigent.
We conducted a
Rapid Evidence Appraisal
on: the risk of influenza in HWs, transmission risk from HWs to patients, the benefit of HW vaccination, and strategies for improving uptake. We aimed to capture a ‘whole-of-system’ perspective to consider possible benefits for HWs, employers and patients.
Methods
We executed a comprehensive search of the available literature published from 2006 to 2018 in the English language. We developed search terms for seven separate questions following the PICO framework (population, intervention, comparators, outcomes) and queried nine databases.
Results
Of 3784 publications identified, 52 met inclusion criteria. Seven addressed HW influenza risk, of which four found increased risk; 15 addressed influenza vaccine benefit to HWs or their employers, of which 10 found benefit; 11 addressed influenza transmission from HWs to patients, of which 6 found evidence for transmission; 12 unique studies addressed whether vaccinating HWs produced patient benefit, of which 9 concluded benefits accrued. Regarding the number of HWs needed to vaccinate (NNV) to deliver patient benefit, NNV estimates ranged from 3 to 36,000 but were in significant disagreement. Fourteen studies provided insights on strategies to improve uptake; the strongest evidence was for mandatory vaccination.
Conclusions
The evidence on most questions related to influenza vaccination in HWs is mixed and often of low-quality. Substantial heterogeneity exists in terms of study designs and settings, making comparison between studies difficult. Notwithstanding these limitations, a majority of studies suggests that influenza vaccination benefit HWs and their employers; and HWs are implicated in transmission events. The effects of vaccinating HWs on patient morbidity and mortality may include reductions in all-cause mortality and influenza-like illness (ILI). Taken together, the evidence suggests that HW vaccination is an important policy for HWs themselves, their employers, and their patients.
Identifying successful strategies to increase COVID-19 vaccination among skilled nursing facility (SNF) residents and staff is integral to preventing future outbreaks in a continually overwhelmed system. OBJECTIVE To determine whether a multicomponent vaccine campaign would increase vaccine rates among SNF residents and staff. DESIGN, SETTING, AND PARTICIPANTS This was a cluster randomized trial with a rapid timeline (December 2020-March 2021) coinciding with the Pharmacy Partnership Program (PPP). It included 133 SNFs in 4 health care systems across 16 states: 63 and 70 facilities in the intervention and control arms, respectively, and participants included 7496 long-stay residents (>100 days) and 17 963 staff. INTERVENTIONS Multicomponent interventions were introduced at the facility level that included: (1) educational material and electronic messaging for staff; (2) town hall meetings with frontline staff (nurses, nurse aides, dietary, housekeeping); (3) messaging from community leaders; (4) gifts (eg, T-shirts) with socially concerned messaging; (5) use of a specialist to facilitate consent with residents' proxies; and (6) funds for additional COVID-19 testing of staff/residents.
MAIN OUTCOMES AND MEASURESThe primary outcomes of this study were the proportion of residents (from electronic medical records) and staff (from facility logs) who received a COVID-19 vaccine (any), examined as 2 separate outcomes. Mixed-effects generalized linear models with a binomial distribution were used to compare outcomes between arms, using intent-to-treat approach. Race was examined as an effect modifier in the resident outcome model.
RESULTSMost facilities were for-profit (95; 71.4%), and 1973 (26.3%) of residents were Black. Among residents, 82.5% (95% CI, 81.2%-83.7%) were vaccinated in the intervention arm, compared with 79.8% (95% CI, 78.5%-81.0%) in the usual care arm (marginal difference 0.8%; 95% CI, −1.9% to 3.7%). Among staff, 49.5% (95% CI, 48.4%-50.6%) were vaccinated in the intervention arm, compared with 47.9% (95% CI, 46.9%-48.9%) in usual care arm (marginal difference: −0.4%; 95% CI, −4.2% to 3.1%). There was no association of race with the outcome among residents.
CONCLUSIONS AND RELEVANCEA multicomponent vaccine campaign did not have a significant effect on vaccination rates among SNF residents or staff. Among residents, vaccination rates were high. However, half the staff remained unvaccinated despite these efforts. Vaccination campaigns to target SNF staff will likely need to use additional approaches.
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