Random stacking template of polymer spheres and water soluble particles to fabricate porous hydroxyapatite with interconnected pores

Tang, Yufei; Qian, Miao; Zhao, Kun; Zhu, Minke; Wu, Zixiang

doi:10.1016/j.ceramint.2013.11.120

Cited by 9 publications

(2 citation statements)

References 16 publications

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“…Hydroxyapatite (HAp) bone grafts have been clinically applied for many years in the fields of orthopedics and oral surgery as nonbioresorbable artificial bone grafts with excellent osteoconductivity 1,2) . Many reports have investigated the introduction of pores into HAp bone grafts [3][4][5][6][7][8][9][10][11][12] ; most clinically used HAp bone grafts are characterized by their pore structure. Most of these reports focus on micro-to macro-sized pores, especially interconnecting pore structures, which are expected to fuse with surrounding bone tissue through entry into cells and tissues [7][8][9][10][11][12][13] .…”

Section: Introductionmentioning

confidence: 99%

“…Many reports have investigated the introduction of pores into HAp bone grafts [3][4][5][6][7][8][9][10][11][12] ; most clinically used HAp bone grafts are characterized by their pore structure. Most of these reports focus on micro-to macro-sized pores, especially interconnecting pore structures, which are expected to fuse with surrounding bone tissue through entry into cells and tissues [7][8][9][10][11][12][13] . Unfortunately, these pore structures make little contribution to improved bioresorption.…”

Section: Introductionmentioning

confidence: 99%

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Fabrication of bioresorbable hydroxyapatite bone grafts through the setting reaction of calcium phosphate cement

et al. 2022

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We prepared hydroxyapatite (HAp) bone grafts by the setting reaction of calcium phosphate cement, and investigated the effects of the porosity and crystallinity on the osteoconductivity and bioresorbability. We examined the effect of the water-mixing ratio, pressure, and post-heat treatment temperature during preparation on the crystallite size and porosity of the HAp blocks. The quantity of protein adsorption increased with increasing porosity and specific surface area (SSA) of the HAp blocks, whereas the initial cell attachment was similar despite the different porosities and crystallinities. In in vitro dissolution tests with a pH 5.5 buffer, which mimics an osteoclast-created Howship's lacuna, both the porosity and SSA of the HAp blocks affected the solubility; most likely due to the increased contact area with the buffer. Thus, HAp blocks prepared by the setting reaction of calcium phosphate cement could be applicable for bioresorbable HAp bone grafts because of the high porosity and SSA.

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