Random inbreeding, isonymy, and population isolates in Argentina

Abstract

Population isolates are an important tool in identifying and mapping genes of Mendelian diseases and complex traits. The geographical identification of isolates represents a priority from a genetic and health care standpoint. The purpose of this study is to analyze the spatial distribution of consanguinity by random isonymy (F ST

Biosocial correlates and spatial distribution of consanguinity in South America

“…With respect to Chile, most towns that make up this cluster are located in the central regions of the country with a variety of surnames measured by the isonymy method : 298 (Valparaíso), 168 (O'Higgins), and 192 (Maule) (Barrai et al, ). As for Argentina, the cities in this cluster are also located in regions south of the country, showing less consanguinity by isonymy in relation to northern Argentina (Dipierri et al, ).…”

“…). The other mid‐level grouping in Brazil occurred in the south and also integrated with two Argentine cities, Corrientes and Posadas , located in the Northwest region of Argentina, which presented high levels of consanguinity by random isonymy compared with the southern regions of the country (Dipierri et al, ). One of the groups of medium level of consanguinity included cities of Peru, Colombia, and Ecuador, most of them located in the Andes with elevations above 2,500 m sea level, so it is possible that this isolation factor constitutes the major determinant of observed consanguinity levels.…”

“…It is a well‐established fact that effects of consanguineous marriages include an increased risk of recessive autosomal disorder, but the effects of consanguinity also manifest in other pregnancy outcomes, such as higher repetition of spontaneous abortions, low birth weight, multifactorial congenital malformations, and mental retardation (Abdulrazzaq et al, ; Honeyman et al, ; Metgud et al, ). Previous studies relating consanguinity to socioeconomic factors and adverse pregnancy outcomes in Latin American populations are scarce (Dipierri et al, ; Liascovich et al, ; Orioli et al, ). The work of Liascovich et al () was made with data collected by the Latin American Collaborative Study on Congenital Malformations (ECLAMC; http://www.eclamc.org).…”

Analisis temporal y espacial de las muertes infantiles por microcefalia en Argentina (1998-2012).

“…Por otra parte el análisis de la estructura genética isonímica del país en base a la distribución y frecuencia de los apellidos de los electores demuestra que si bien la consanguinidad por isonimia al azar muestra una marcada variación regional y departamental, los valores más altos se presentan en el norte y el oeste de Argentina (15) .…”

Population genetic analysis of the population of Transcarpathian region based on surname data

“…Використання прізвищ як маркерів має ряд переваг: фінансово не затратні, можливість швидко аналізувати великі обсяги даних (тотальні списки). За допомогою прізвищ було проаналізовано багато різних народів світу як на індивідуальному, так і на популяційному рівнях [6][7][8][9][10][11][12][13][14][15][16][17][18].…”