1984
DOI: 10.2307/2531147
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Random-Effects Models for Serial Observations with Binary Response

Abstract: This paper presents a general mixed model for the analysis of serial dichotomous responses provided by a panel of study participants. Each subject's serial responses are assumed to arise from a logistic model, but with regression coefficients that vary between subjects. The logistic regression parameters are assumed to be normally distributed in the population. Inference is based upon maximum likelihood estimation of fixed effects and variance components, and empirical Bayes estimation of random effects. Exact… Show more

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Cited by 667 publications
(325 citation statements)
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“…In our context, and for fixed values of the variance components, estimation of the model's fixed and random effects presents no problem. These can be obtained using Penalized Quasi-likelihood (PQL) methods (Stiratelli et al 1984, Schall 1991, Breslow and Clayton 1993. PQL is a very simple method for estimation of GLMMs, and can be easily implemented by iterative fitting a working linear mixed model to a working dependent variable z, on the basis of a Fisher scoring algorithm which involves a weight matrix W that is updated at each iteration (we describe this point in detail in Appendix A).…”
Section: Mixed Model Representationmentioning
confidence: 99%
“…In our context, and for fixed values of the variance components, estimation of the model's fixed and random effects presents no problem. These can be obtained using Penalized Quasi-likelihood (PQL) methods (Stiratelli et al 1984, Schall 1991, Breslow and Clayton 1993. PQL is a very simple method for estimation of GLMMs, and can be easily implemented by iterative fitting a working linear mixed model to a working dependent variable z, on the basis of a Fisher scoring algorithm which involves a weight matrix W that is updated at each iteration (we describe this point in detail in Appendix A).…”
Section: Mixed Model Representationmentioning
confidence: 99%
“…In linear models, this problem is addressed by using restricted maximum likelihood (REML) estimation (Patterson and Thompson, 1971). Unfortunately, the REML concept cannot be directly applied to generalized linear mixed models, although there are some ad-hoc approaches (Schall, 1991;Breslow and Clayton, 1993;McGilchrist, 1994;Stiratelli et al, 1984;Noh and Lee, 2007). The assumption that downward bias is due to the small number of clusters was confirmed by eliminating the person random effect, simulating data for 10 and 100 items (with J = 100 and ψ 2 = 3.290) and finding that there is a significant downward bias for the item variance with 10 items but not with 100 items, estimated, respectively, as −0.25 (SE = 0.05) and −0.01 (SE = 0.02) using 1000 replications.…”
Section: Tablementioning
confidence: 99%
“…The Penalized Quasi-Likelihood method (PQL) [11,33,34] also approximates the integrand; more intuitively put, PQL approximates the GLMM with a linear mixed model. This is achieved by considering a Taylor expansion of the response function and by subsequently rewriting this expression in terms of an adjusted dependent variable on which estimation procedures for LMM can be implemented.…”
Section: Estimation Through Likelihood-based Approximation Methodsmentioning
confidence: 99%