Random and oriented electrospun fibers based on a multicomponent, in situ clickable elastin-like recombinamer system for dermal tissue engineering

Torre, Israel González de; Ibáñez‐Fonseca, Arturo; Quintanilla, L.; Alonso, Matilde; Rodríguez-Cabello, J Carlos

doi:10.1016/j.actbio.2018.03.027

Cited by 36 publications

(24 citation statements)

References 73 publications

(90 reference statements)

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“…[256] Electrospun ELR-based nanofiber matrices have been used to develop 3D scaffolds for several applications, which include dermal repair and as vascular grafts studies. [257][258][259] Similarly, salt leaching coupled with gas foaming has been used to produce macroporous scaffolds based on crosslinked ELR hydrogels. [260,261] This technique enables the pore size to be tuned on the microscale for optimal cell interaction as per requirement.…”

Section: Architecture and Stiffness Controlmentioning

confidence: 99%

Elastin‐Like Recombinamers: Deconstructing and Recapitulating the Functionality of Extracellular Matrix Proteins Using Recombinant Protein Polymers

Acosta

Quintanilla‐Sierra

Mbundi

et al. 2020

Adv Funct Materials

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In the development of tissue engineering strategies to replace, remodel, regenerate, or support damaged tissue, the development of bioinspired biomaterials that recapitulate the physicochemical characteristics of the extracellular matrix has received increased attention. Given the compositional heterogeneity and tissue-to-tissue variation of the extracellular matrix, the design, choice of polymer, crosslinking, and nature of the resulting biomaterials are normally depended on intended application. Generally, these biomaterials are usually made of degradable or nondegradable biomaterials that can be used as cell or drug carriers. In recent years, efforts to endow reciprocal biomaterial-cell interaction properties in scaffolds have inspired controlled synthesis, derivatization, and functionalization of the polymers used. In this regard, elastin-like recombinant proteins have generated interest and continue to be developed further owing to their modular design at a molecular level. In this review, the authors provide a summary of key extracellular matrix features relevant to biomaterials design and discuss current approaches in the development of extracellular matrix-inspired elastin-like recombinant protein based biomaterials.

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Section: Architecture and Stiffness Controlmentioning

confidence: 99%

Elastin‐Like Recombinamers: Deconstructing and Recapitulating the Functionality of Extracellular Matrix Proteins Using Recombinant Protein Polymers

Acosta

Quintanilla‐Sierra

Mbundi

et al. 2020

Adv Funct Materials

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“…This study showed how differences in fiber orientation, spacing and fraction affected the final physical and mechanical properties (burst pressure, compliance and suture retention) of the ELP-based VGs (Caves et al, 2010 ). ELRs alone have been used as biomaterials for electrospinning with the aim of forming an elastic and resistant mesh that can be used for tissue-engineering applications (Fernández-Colino et al, 2018 ; González de Torre et al, 2018 ) and, more specifically, for cardiovascular applications (Putzu et al, 2016 , 2019 ). González de Torre et al were the first to synthesize stable electrospun ELR fibers without the need for any additional crosslinking step after the electrospinning process.…”

Section: Vascular Grafts (Vgs)mentioning

confidence: 99%

Elastin-Based Materials: Promising Candidates for Cardiac Tissue Regeneration

Torre

Alonso

Rodríguez-Cabello

2020

Front. Bioeng. Biotechnol.

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Stroke and cardiovascular episodes are still some of the most common diseases worldwide, causing millions of deaths and costing billions of Euros to healthcare systems. The use of new biomaterials with enhanced biological and physical properties has opened the door to new approaches in cardiovascular applications. Elastin-based materials are biomaterials with some of the most promising properties. Indeed, these biomaterials have started to yield good results in cardiovascular and angiogenesis applications. In this review, we explore the latest trends in elastin-derived materials for cardiac regeneration and the different possibilities that are being explored by researchers to regenerate an infarcted muscle and restore its normal function. Elastin-based materials can be processed in different manners to create injectable systems or hydrogel scaffolds that can be applied by simple injection or as patches to cover the damaged area and regenerate it. Such materials have been applied to directly regenerate the damaged cardiac muscle and to create complex structures, such as heart valves or new bio-stents that could help to restore the normal function of the heart or to minimize damage after a stroke. We will discuss the possibilities that elastin-based materials offer in cardiac tissue engineering, either alone or in combination with other biomaterials, in order to illustrate the wide range of options that are being explored. Moreover, although tremendous advances have been achieved with such elastin-based materials, there is still room for new approaches that could trigger advances in cardiac tissue regeneration.

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“…In 2018, de Torre et al described electrospinning of clickable elastin-like recombinamers that do not require addition of potentially cytotoxic cross-linkers, while allowing for the incorporation of different functionalities (i.e. RGD motifs) to support cell adhesion and proliferation (Gonzalez de Torre et al, 2018 ). As outlined in this section many different biopolymers were used and developed to generate 3D skin models; however, collagen I, with the abovementioned limitations, is still predominantly used (Sahana and Rekha, 2018 ).…”

Section: Physiological Skin Model In 3dmentioning

confidence: 99%

Advances in the Biofabrication of 3D Skin in vitro: Healthy and Pathological Models

Randall

Jüngel²,

Rimann

et al. 2018

Front. Bioeng. Biotechnol.

134

111

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The relevance for in vitro three-dimensional (3D) tissue culture of skin has been present for almost a century. From using skin biopsies in organ culture, to vascularized organotypic full-thickness reconstructed human skin equivalents, in vitro tissue regeneration of 3D skin has reached a golden era. However, the reconstruction of 3D skin still has room to grow and develop. The need for reproducible methodology, physiological structures and tissue architecture, and perfusable vasculature are only recently becoming a reality, though the addition of more complex structures such as glands and tactile corpuscles require advanced technologies. In this review, we will discuss the current methodology for biofabrication of 3D skin models and highlight the advantages and disadvantages of the existing systems as well as emphasize how new techniques can aid in the production of a truly physiologically relevant skin construct for preclinical innovation.

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Random and oriented electrospun fibers based on a multicomponent, in situ clickable elastin-like recombinamer system for dermal tissue engineering

Cited by 36 publications

References 73 publications

Elastin‐Like Recombinamers: Deconstructing and Recapitulating the Functionality of Extracellular Matrix Proteins Using Recombinant Protein Polymers

Elastin‐Like Recombinamers: Deconstructing and Recapitulating the Functionality of Extracellular Matrix Proteins Using Recombinant Protein Polymers

Elastin-Based Materials: Promising Candidates for Cardiac Tissue Regeneration

Advances in the Biofabrication of 3D Skin in vitro: Healthy and Pathological Models

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