RanBPM, a novel interaction partner of the brain‐specific protein p42^IP4/centaurin α‐1

Abstract

Abbreviations used: ARF, ADP ribosylation factor; ARFGAP, ARF GTPase activating protein; CHO cells, Chinese hamster ovary cells; CTLH domain, C-terminal to LisH domain; GFP, green fluorescent protein; GST, glutathione S-transferase; HEK 293, human embryonic kidney cell line 293; Ins(1,3,4,5)P 4 (IP4), inositol 1,3,4,5-tetrakisphosphate; LisH domain, lissencephaly type-1 like homology domain; PH, pleckstrin homology; PtdIns(3,4,5)P 3, phosphatidylinositol 3,4,5-trisphosphate; RanBPM, Ran binding protein in microtubule-organizing center; Sf9, insect cell line from Spodoptera frugiperda; SPRY, proteinprotein interaction domain from Dictyostelium dual-specificity kinase splA and ryanodine receptor.

Tubulin potentiates the interaction of the metalloendopeptidase nardilysin with the neuronal scaffold protein p42IP4/centaurin-α1 (ADAP1)

“…Importantly, AD and Down syndrome brains display the decreased cellular expression of NRD, ADAM10, or ADAM17 and a reduction of neurons that co-express NRD with either ADAM10 or ADAM17. We have also previously reported that p42 IP4 can interact with the Ran-binding protein M (RanBPM; Haase et al 2008). RanBPM has been shown to interact with β-secretase (BACE1) and to increase the level of Aβ-peptides (Lakshmana et al 2009).…”

Insulin signalling in mushroom body neurons regulates feeding behaviour inDrosophilalarvae

“…RanBPM has been implicated in various signalling pathways as a putative scaffolding protein (e.g. Bai et al, 2003;Mikolajczyk et al, 2003;Menon et al, 2004;Brunkhorst et al, 2005;Hafizi et al, 2005;Haase et al, 2008;Atabakhsh et al, 2009;Gong et al, 2009;Kim et al, 2009;Chang et al, 2010) (reviewed by Murrin and Talbot, 2007). RanBPM expression in PC12 cells promotes TrkB-dependent activation of the serine-threonine kinase Akt, a target of insulin signalling (Yin et al, 2010).…”

Identification of RanBP 9/10 as Interacting Partners for Protein Kinase C (PKC) γ/δ and the D1Dopamine Receptor: Regulation of PKC-Mediated Receptor Phosphorylation

“…A to C, PKC␥; D to F, PKC␦. that is expressed in a variety of tissues including the brain (Wang et al, 2004;Haase et al, 2008;Schulze et al, 2008) and is known to interact with several proteins that include the protein Ran and the receptor protein tyrosine kinase for hepatocyte growth factor, MET (Wang et al, 2004). It is noteworthy that there is a closely related protein, RanBP9, that has high sequence similarity to RanBP10 (Wang et al, 2004) and has been found to associate with several GPCRs, including the -opioid receptor and the metabotropic glutamate receptors (mGluRs) mGluR2 and mGluR8, as well as with MET (Wang et al, 2004;Seebahn et al, 2008;Talbot et al, 2009).…”

“…Although RanBP10 and RanBP9 do not seem to mediate the EtOH-induced attenuation of PKC␥ and PKC␦ kinase activities, they could function as important PKC scaffolding proteins. In fact, a role for RanBP10 and RanBP9 as scaffolding proteins has been well described previously (Wang et al, 2004;Haase et al, 2008;Talbot et al, 2009). In particular, both Ran10 and RanBP9 have been reported to associate with receptors expressed at the plasma membrane that include the MET tyrosine kinase receptor and the -opioid receptor, respectively (Wang et al, 2004;Talbot et al, 2009).…”