RANBP1 (RAN Binding Protein 1): The Missing Genetic Piece in Cancer Pathophysiology and Other Complex Diseases

Audia, Salvatore; Brescia, Carolina; Dattilo, Vincenzo; D’Antona, Lucia; Calvano, Pierluigi; Iuliano, Rodolfo; Trapasso, Francesco; Perrotti, Nicola; Amato, Rosario

doi:10.3390/cancers15020486

Cited by 10 publications

(8 citation statements)

References 79 publications

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“…RanBP1 is known to act as an adjuvant to Ran and to be involved in mitosis and in the cell cycle [ 30 ]. RanBP1 shows the highest activity in the early and late stages of the cell cycle, in order to help Ran function [ 31 ]. Additionally, RanBP1 plays an essential role in the directional migration of neural crest cells during development [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

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RanBP1: A Potential Therapeutic Target for Cancer Stem Cells in Lung Cancer and Glioma

Kahm

Kim

2023

IJMS

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Cancer stem cells (CSCs) are known to be one of the factors that make cancer treatment difficult. Many researchers are thus conducting research to efficiently destroy CSCs. Therefore, we sought to suggest a new target that can efficiently suppress CSCs. In this study, we observed a high expression of Ran-binding protein 1 (RanBP1) in lung cancer stem cells (LCSCs) and glioma stem cells (GSCs). Upregulated RanBP1 expression is strongly associated with the expression of CSC marker proteins and CSC regulators. In addition, an elevated RanBP1 expression is strongly associated with a poor patient prognosis. CSCs have the ability to resist radiation, and RanBP1 regulates this ability. RanBP1 also affects the metastasis-associated epithelial–mesenchymal transition (EMT) phenomenon. EMT marker proteins and regulatory proteins are affected by RanBP1 expression, and cell motility was regulated according to RanBP1 expression. The cancer microenvironment influences cancer growth, metastasis, and cancer treatment. RanBP1 can modulate the cancer microenvironment by regulating the cytokine IL-18. Secreted IL-18 acts on cancer cells and promotes cancer malignancy. Our results reveal, for the first time, that RanBP1 is an important regulator in LCSCs and GSCs, suggesting that it holds potential for use as a potential therapeutic target.

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Section: Discussionmentioning

confidence: 99%

“…IL-18, regulated by RanBP1, was discovered 30 years ago and causes a variety of biological effects [ 31 ]. We found that IL-18 re-regulates RanBP1 to form an autocrine loop.…”

Section: Discussionmentioning

confidence: 99%

RanBP1: A Potential Therapeutic Target for Cancer Stem Cells in Lung Cancer and Glioma

Kahm

Kim

2023

IJMS

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“…We hypothesise asthma might in uence ROS homeostasis and innate immunity of CRSwNP, which needs to be explored further. RanBP1 is a certain cell cycle regulatory protein belonging to the regulator of the Ran-GTPase, and plays regulatory functions in the RAN network 24 . Transforming growth factor-β (TGF-β), which is particularly important in promoting remodeling in airway diseases like asthma and CRSwNP 25 .…”

Section: Discussionmentioning

confidence: 99%

Proteomics Comparison of Nasal Lavage Fluid in Chronic Rhinosinusitis with Nasal Polyps with or without Asthma

Guo,

Yang,

Yao

et al. 2023

Preprint

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Background Chronic rhinosinusitis with nasal polyps (CRSwNP) accompanied by asthma generally has a poor prognosis. We used proteomic methods to explore the effect of comorbid asthma on CRSwNP. Methods Differentially expressed proteins (DEPs) were identified separately in nasal lavage fluid (NLF) between control, CRSwNP and CRSwNP with asthma groups by bioinformatics analysis based on proteomics. The key proteins involved in effect of comorbid asthma on CRSwNP were further identified according to gradient change of DEPs between the three groups by DIA quantification. Results Compared to the control, 1377 DEPs and 1006 DEPs were identified in NLF from CRSwNP and CRSwNP with asthma groups, respectively. The biological function of DEPs in CRSwNP was highly similar to that in CRSwNP with asthma by GO and KOG enrichment analysis, but the enriched pathways in the two groups were different, mainly enriched in ‘Hippo signaling pathway’, ‘Endocytosis’ and ‘Wnt signaling pathway’, ‘Carbon metabolism’, respectively. Two up-regulated proteins PRDX5, RanBP1 and a down-regulated protein KRT9 were identified as the key proteins involved in asthma affecting CRSwNP because they showed the same changing trends whether in CRSwNP or CRSwNP with asthma, and the change was most significant in CRSwNP with asthma. Conclusion Comorbid asthma can promote the occurrence and development of nasal polyps through related key proteins and signaling pathways.

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“…Compared to HIV-1, HIV-2 managed to downregulate the expression of RANBP1, which deserves significant attention. This protein was found to contain a nuclear export signal (NES) domain that is similar in structure and function to that found in HIV Rev; therefore, it is hypothesized that it shares a step in the post-transcriptional pathway with Rev [ 90 ]. Its downregulation by HIV-2 raises questions about whether it could be implicated in the suppression of the transport of proviral transcripts.…”

Section: Discussionmentioning

confidence: 99%

Comparative Analysis of Differential Cellular Transcriptome and Proteome Regulation by HIV-1 and HIV-2 Pseudovirions in the Early Phase of Infection

Linkner,

Ambrus,

Kunkli

et al. 2023

IJMS

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In spite of the similar structural and genomic organization of human immunodeficiency viruses type 1 and 2 (HIV-1 and HIV-2), striking differences exist between them in terms of replication dynamics and clinical manifestation of infection. Although the pathomechanism of HIV-1 infection is well characterized, relatively few data are available regarding HIV-2 viral replication and its interaction with host–cell proteins during the early phase of infection. We utilized proteo-transcriptomic analyses to determine differential genome expression and proteomic changes induced by transduction with HIV-1/2 pseudovirions during 8, 12 and 26 h time-points in HEK-293T cells. We show that alteration in the cellular milieu was indeed different between the two pseudovirions. The significantly higher number of genes altered by HIV-2 in the first two time-points suggests a more diverse yet subtle effect on the host cell, preparing the infected cell for integration and latency. On the other hand, GO analysis showed that, while HIV-1 induced cellular oxidative stress and had a greater effect on cellular metabolism, HIV-2 mostly affected genes involved in cell adhesion, extracellular matrix organization or cellular differentiation. Proteomics analysis revealed that HIV-2 significantly downregulated the expression of proteins involved in mRNA processing and translation. Meanwhile, HIV-1 influenced the cellular level of translation initiation factors and chaperones. Our study provides insight into the understudied replication cycle of HIV-2 and enriches our knowledge about the use of HIV-based lentiviral vectors in general.

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RANBP1 (RAN Binding Protein 1): The Missing Genetic Piece in Cancer Pathophysiology and Other Complex Diseases

Cited by 10 publications

References 79 publications

RanBP1: A Potential Therapeutic Target for Cancer Stem Cells in Lung Cancer and Glioma

RanBP1: A Potential Therapeutic Target for Cancer Stem Cells in Lung Cancer and Glioma

Proteomics Comparison of Nasal Lavage Fluid in Chronic Rhinosinusitis with Nasal Polyps with or without Asthma

Comparative Analysis of Differential Cellular Transcriptome and Proteome Regulation by HIV-1 and HIV-2 Pseudovirions in the Early Phase of Infection

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