RAMONA-4B a computer code with three-dimensional neutron kinetics for BWR and SBWR system transient - user`s manual

Rohatgi, U.S.; Cheng, H.S.; Khan, Hiba; Mallen, A.N.; Neymotin, L.

doi:10.2172/576035

Cited by 6 publications

(6 citation statements)

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“…They selected 1 representative clinical trial per chemotherapy regimen based on the number of eligible patients, patient background, and study design (5 clinical trials in total). Second, we digitized the Kaplan-Meier (KM) curves of OS and PFS for the GEM arm in selected trials using WebPlotDigitizer by Rohatgi (version 4.3) to simulate individual patient data. Based on the study design, several patients, and patient characteristics of each trial, we confirmed the homogeneity of the GEM arm in each trial and integrated the digitization data of the GEM arms in the respective PFS and OS periods.…”

Section: Methodsmentioning

confidence: 99%

Comparative Outcomes of First-Line Chemotherapy for Metastatic Pancreatic Cancer Among the Regimens Used in Japan

et al. 2022

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IMPORTANCE Various first-line chemotherapy treatment regimens for patients with metastatic pancreatic cancer have been approved in Japan, including gemcitabine (GEM); fluorouracil, leucovorin, irinotecan, and oxaliplatin combination (FOLFIRINOX); GEM plus albumin-bound paclitaxel (GEM+NPTX), and S-1 (tegafur + gimeracil + oteracil). However, direct comparisons of these chemotherapy regimens are limited. OBJECTIVETo assess the short-term and long-term outcomes associated with first-line chemotherapy regimens for metastatic pancreatic cancer compared with chemotherapy regimens recommended in Japanese guidelines. DATA SOURCES In this systematic review and network meta-analysis, the bibliographic databases PubMed, Cochrane Library, and Web of Science, as well as medical journals published between January 1, 2002, and December 31, 2018, were searched for clinical trials comparing chemotherapy regimens. STUDY SELECTION Randomized 2-arm clinical trials evaluating first-line chemotherapy for advanced or metastatic pancreatic cancer were included. DATA EXTRACTION AND SYNTHESIS The Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) Extension Statement for Reporting of Systematic Reviews IncorporatingNetwork Meta-analyses of Health Care Interventions was followed for data abstractions. Data were pooled using a random-effects model. The SIGN 50 Quality Assessment Instrument was used to assess the risk of bias and overall study quality of the selected trials. MAIN OUTCOMES AND MEASURESThe primary end point was overall survival (OS), and the secondary end point was progression-free survival (PFS) compared with GEM for first-line chemotherapy for metastatic pancreatic cancer. The Kaplan-Meier curve of GEM from the literature and the estimated hazard ratios (HRs) were used to model the long-term associations to calculate the area under the curve (AUC) (person-months) for OS and PFS of each chemotherapy. Sensitivity analyses with multiple functional models were conducted to confirm the long-term estimations. RESULTS A total of 22 regimens (25 studies) for OS and a total of 18 regimens (21 studies) for PFS were identified from literature. The total number of participants was 10 186, with 5856 male (57.5%) and 4330 female (42.5%). The FOLFIRINOX and GEM+NPTX regimens were associated with reduction in the risk of death, with an HR of 0.57 (95% CI, 0.41-0.79) and 0.72 (95% CI, 0.55-0.95) compared with GEM, respectively. The curve estimation also showed that FOLFIRINOX had the largest AUC for survival at 15.49 person-months (range, 13.84-15.51 person-months), followed by (continued) Key Points Question What are the comparative short-term and long-term outcomes associated with first-line chemotherapy regimens for patients with metastatic pancreatic cancer, and how do they compare with chemotherapy regimens recommended in Japanese guidelines? Findings In this systematic review and network meta-analysis of 25 randomized clinical trials assessing firstline chemotherapy regimens for advanced or metastatic pancreati...

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Section: Methodsmentioning

confidence: 99%

Comparative Outcomes of First-Line Chemotherapy for Metastatic Pancreatic Cancer Among the Regimens Used in Japan

et al. 2022

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“…Database searches, study screening and effect size extraction were all performed by one co-author (CM). Most of the data in the papers were presented graphically, and thus numerical data was obtained using the digitalising software WebPlotDigitiser Version 4.4 (Rohatgi, 2013), which has been shown to be a valid and accurate method of data extraction for meta-analyses (Drevon et al, 2017).…”

Section: Literature Reviewmentioning

confidence: 99%

The impact of chemical pollution across major life transitions: a meta-analysis on oxidative stress in amphibians

Martin,

Capilla-Lasheras,

Monaghan

et al. 2023

Preprint

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Among human actions threatening biodiversity, the release of anthropogenic chemical pollutants -which have become ubiquitous in the environment- is a major concern. Chemical pollution can induce oxidative stress and damage by causing the overproduction of reactive oxygen species (ROS), and affecting the antioxidant system. In species undergoing metamorphosis (~80% of all extant animal species), antioxidant responses to chemical pollution may differ between pre- and post-metamorphic stages. Here, we meta-analysed (N = 86 studies, k = 2,012 estimates) the impact of chemical pollution on the redox balance across the three major amphibian life stages (embryo, larva, adult). Before metamorphosis, embryos and larvae activate their antioxidant pathways and do not show increased oxidative damage. In contrast, post-metamorphic individuals show unnoticeable antioxidant responses, and a marked oxidative damage in lipids. Also, type of pollutant (i.e., organic vs inorganic) promotes contrasting effects across amphibian life stages. Our findings show a divergent evolution of the redox balance in response to pollutants across life transitions of metamorphosing amphibians, likely linked to the characteristics of each life stage. Further comparative mechanistic approaches to wildlife responses to global changes will improve our understanding of these eco-evo-devo processes.

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“…of the published work by Shukor et al [6] of Mathematical Modeling of the Molybdenum Blue Production from Serratia sp. strain DRY5 was processed using the software Webplotdigitizer 2.5 [9], which helps to digitizes the scanned figure and has been widely used and acknowledged by many researchers because of its precision and reliability [3,5,6,10]. CurveExpert Professional software (Version 2.6.5) was used to model the data after been processed.…”

Section: Data Acquisitionmentioning

confidence: 99%

Molybdenum Blue Production from Serratia sp. strain DRY5: Secondary Modeling

Sabó

Yahuza²,

Shukor

2021

Bioremed Sci Technol Res

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In this work, kinetic growth models such as Luong, Yano, Teissier-Edward, Aiba, Haldane, Monod, Han and Levenspiel were used to model molybdenum blue production from Serratia sp. strain DRY5. Based on statistical analyses such as root-mean-square error (RMSE), adjusted coefficient of determination (adjR2), bias factor (BF), and accuracy factor (AF), the Monod model was chosen as the best. The calculated values for the monod constants qmax (the maximum specific substrate degradation rate (h−1), and Ks (concentration of substrate at the half maximal degradation rate (mg/L)) were found to be 3.86 (95% confidence interval of 2.29 to 5.43), and 43.41 (95% confidence interval of 12.36 to 74.46) respectively. The novel constants discovered during the modelling exercise could be used in further secondary modelling.

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RAMONA-4B a computer code with three-dimensional neutron kinetics for BWR and SBWR system transient - user`s manual

Cited by 6 publications

References 0 publications

Comparative Outcomes of First-Line Chemotherapy for Metastatic Pancreatic Cancer Among the Regimens Used in Japan

Comparative Outcomes of First-Line Chemotherapy for Metastatic Pancreatic Cancer Among the Regimens Used in Japan

The impact of chemical pollution across major life transitions: a meta-analysis on oxidative stress in amphibians

Molybdenum Blue Production from Serratia sp. strain DRY5: Secondary Modeling

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