Ramipril Efficacy in Patients With Arterial Hypertension and Ischemic Heart Disease

Чесникова, А. И.; Koshenskaja, I. N.; Terentyev, V. P.; Mozhaeva, N. N.; Bedareva, I. V.; Lavrik, L. A.; Zhertovsky, T. V.

doi:10.20996/1819-6446-2008-4-2-41-46

Cited by 2 publications

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References 2 publications

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“…Продемонстрированное в исследовании эффективное (достижение целевых уровней САД и ДАД), достаточно быстрое (первые 2-4 нед) снижение повышенного АД, стабильное сохранение эффекта через 12 нед терапии на фоне приема фиксированной комбинации амлодипина и рамиприла было показано ранее [5,16,17]. Однако у пациентов после перенесенного ОКС, получивших рентгенэндоваскулярное вмешательство, применение фиксированной комбинацией рамиприла и амлодипина (Эгипрес ® ) было впервые.…”

Section: Discussionunclassified

“…В числе лекарственных препаратов, влияющих на прогноз жизни пациентов, необходимо назначение ингибиторов ангиотензин-превращающего фермента (ИАПФ) [1], прежде всего, рамиприла, который обладает большой доказательной базой относительно положительного влияния на все этапы сердечно-сосудистого континуума и улучшения прогноза у больных, перенесших ОКС [4][5][6][7].…”

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Antihypertensive Efficacy of Fixed Combination of Amlodipine and Ramipril in Patients with Arterial Hypertension and Very High Cardiovascular Risk

Korennova

Podolnaya

Prihodko

et al. 2019

Racionalʹnaâ farmakoterapiâ v kardiologii

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Aim. To evaluate the antihypertensive efficacy and tolerability of a fixed combination of amlodipine and ramipril in hypertensive patients with very high cardiovascular risk. Material and methods. A retrospective cohort study of real clinical practice of prescribing antihypertensive drugs according to 255 medical records of outpatient hypertensive patients with a history of acute coronary syndrome (ACS) and coronary artery stenting was performed in the first part. An open observational study was performed in the second part. 69 people older than 18 years with a history of ACS and coronary artery stenting, without reaching the target blood pressure (BP) level while using free combinations of antihypertensive drugs and with indications for a fixed combination of ramipril and amlodipine were included into the study. Analysis of self-monitoring of BP, office BP, daily BP monitoring (ABPM) and patients’ adherence to treatment (Morisky-Green test) initially, after 4 and after 12 weeks of taking the fixed combination of ramipril and amlodipine was performed to assess the clinical efficacy of the studied drug. Results. It was found that 42.0% of patients did not follow the recommendations for regular intake of antihypertensive drugs. So, hypertension of all patients regarded as false-refractory, which was the basis for the prescription of the fixed combination of ramipril and amlodipine in accordance with clinical guidelines for the diagnosis and treatment of hypertension. After 4 weeks of therapy, there was significant decrease in office BP with the achievement and preservation of the target level by the 12th week, normalization to the 12th week of day and night BP variability in 54.9% of patients. 78.0% of patients followed medical recommendations for regular administration of antihypertensive drugs, none of the patients had adverse events. Conclusion. The use of fixed combinations of drugs, in particular, amlodipine and ramipril as a part of multicomponent therapy in hypertensive patients with very high cardiovascular risk, led to the achievement of target BP by the 4th week of therapy and stable preservation of antihypertensive effect in 12 weeks of treatment as well as gradual normalization of day and night BP variability in more than half of patients. Fixed combination of ramipril and amlodipine allowed to improve adherence of patients to cardiovascular diseases.

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Antihypertensive Efficacy of Fixed Combination of Amlodipine and Ramipril in Patients with Arterial Hypertension and Very High Cardiovascular Risk

Korennova

Podolnaya

Prihodko

et al. 2019

Racionalʹnaâ farmakoterapiâ v kardiologii

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Evaluation of the effectiveness of drug treatment in patients with arterial hypertension and insomnia

Vasilieva

Чесникова

Klimenkova

et al. 2021

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Objective: chronic sleep disturbance is a comorbid condition with arterial hypertension, often combined with affective disorders, anxiety, depression. Forced sleep deprivation in patients with hypertension indicates a high activity of the renin‑angiotensin‑aldosterone system (RAAS) and desynchronosis of biological rhythms caused by a probable deficit in melatonin secretion during the night. Timely elimination of any pathological process associated with insomnia and arterial hypertension (AH) in the early stages of its development is a prerequisite for the effectiveness of therapy. Therefore, initial therapy should help neutralize the adverse effects of RAAS and improve the 24‑hour blood pressure (BP) profile. The aim of this study was to determine the therapeutic effect of monotherapy with an angiotensin converting enzyme (ACE) inhibitor, As well as in combination with a synthetic analogue of melatonin, on the course of hypertension and parameters of systemic hemodynamics in patients with first degree hypertension with insomnia at the onset of the disease. Combined therapy with an ACE inhibitor and a synthetic analogue of MT in patients with hypertension and insomnia was accompanied by an improvement in the clinical state, achievement of the target blood pressure level in most patients, positive dynamics of central blood pressure parameters and indicators reflecting the rigidity of peripheral arteries.

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Ramipril Efficacy in Patients With Arterial Hypertension and Ischemic Heart Disease

Cited by 2 publications

References 2 publications

Antihypertensive Efficacy of Fixed Combination of Amlodipine and Ramipril in Patients with Arterial Hypertension and Very High Cardiovascular Risk

Antihypertensive Efficacy of Fixed Combination of Amlodipine and Ramipril in Patients with Arterial Hypertension and Very High Cardiovascular Risk

Evaluation of the effectiveness of drug treatment in patients with arterial hypertension and insomnia

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