Raman Spectroscopy of Pharmaceutical Cocrystals in Nanosized Pores of Mesoporous Silica

Ohta, Ryuichi; Ueno, Yuko; Ajito, Katsuhiro

doi:10.2116/analsci.33.47

Cited by 4 publications

(10 citation statements)

References 30 publications

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“…62 Ohita et al also reported cocrystal formation of caffeine-oxalic acid within MPS. 63 Diffusion-Supported Loading (DiSupLo)…”

Section: The Adsorption Methodsmentioning

confidence: 99%

“…The peak frequencies at 32, 56, and 83 cm –1 are slightly shifted when cocrystals are synthesized in SBA-16, indicating a dominant formation on the surface of SBA-16 without aggregation. 63 …”

Section: Drug-coformer Within Mps Systemsmentioning

confidence: 99%

“…This analysis offers valuable insights into the cocrystallization of caffeine and oxalic acid within SBA-16, as shown by the peak intensities of each component at different molar quantities. 63

Figure 9 Raman spectra of cocrystal with MPS (black line) and the curve (pink line) fitted by cocrystal without MPS (red line), caffeine crystal with and without MPS (blue and green lines), and background of MPS (sand line). …”

Section: Drug-coformer Within Mps Systemsmentioning

confidence: 99%

“…In this situation, the use of 134 and 201 μmol would yield bi-layer and tri-layer cocrystal, respectively. 63

Figure 10 ( a ) Relative peak intensities of cocrystal without MPS and caffeine with and without MPS at various molar ratios. The molar amount dependence is categorized into situations A and B. Schematic illustration of cocrystal caffeine and oxalic acid on the surface of MPS ( b ) in the situation A, ( c ) at the boundary of A and B, and ( d ) in the situation B.…”

Section: Drug-coformer Within Mps Systemsmentioning

confidence: 99%

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Drug-Coformer Loaded-Mesoporous Silica Nanoparticles: A Review of the Preparation, Characterization, and Mechanism of Drug Release

Budiman,

Wardhana,

Ainurofiq

et al. 2024

IJN

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Drug-coformer systems, such as coamorphous and cocrystal, are gaining recognition as highly effective strategies for enhancing the stability, solubility, and dissolution of drugs. These systems depend on the interactions between drug and coformer to prevent the conversion of amorphous drugs into the crystalline form and improve the solubility. Furthermore, mesoporous silica (MPS) is also a promising carrier commonly used for stabilization, leading to solubility improvement of poorly water-soluble drugs. The surface interaction of drug-MPS and the nanoconfinement effect prevent amorphous drugs from crystallizing. A novel method has been developed recently, which entails the loading of drug-coformer into MPS to improve the solubility, dissolution, and physical stability of the amorphous drug. This method uses the synergistic effects of drug-coformer interactions and the nanoconfinement effect within MPS. Several studies have reported successful incorporation of drug-coformer into MPS, indicating the potential for significant improvement in dissolution characteristics and physical stability of the drug. Therefore, this study aimed to discuss the preparation and characterization of drug-coformer within MPS, particularly the interaction in the nanoconfinement, as well as the impact on drug release and physical stability.

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“…62 Ohita et al also reported cocrystal formation of caffeine-oxalic acid within MPS. 63 Diffusion-Supported Loading (DiSupLo)…”

Section: The Adsorption Methodsmentioning

confidence: 99%

Section: Drug-coformer Within Mps Systemsmentioning

confidence: 99%

“…This analysis offers valuable insights into the cocrystallization of caffeine and oxalic acid within SBA-16, as shown by the peak intensities of each component at different molar quantities. 63

Section: Drug-coformer Within Mps Systemsmentioning

confidence: 99%

“…In this situation, the use of 134 and 201 μmol would yield bi-layer and tri-layer cocrystal, respectively. 63

Section: Drug-coformer Within Mps Systemsmentioning

confidence: 99%

See 2 more Smart Citations

Drug-Coformer Loaded-Mesoporous Silica Nanoparticles: A Review of the Preparation, Characterization, and Mechanism of Drug Release

Budiman,

Wardhana,

Ainurofiq

et al. 2024

IJN

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show abstract

“…This makes optical methods promising for studying fluid adsorption in nanopores, including the smallest ones. In particular, spectroscopic techniques based on Raman scattering allow probing of the analyte confined in nanoporous solids [24][25][26][27][28], thus providing direct information about the phase state and interaction with the pore walls. Fundamentally, the molecule's environment affects its vibrations, including modification of the vibrational transition frequencies.…”

Section: Introductionmentioning

confidence: 99%

CARS detection of liquid-like phase appearance in small mesopores

Arakcheev¹,

Bekin²,

Morozov³

2017

Laser Phys.

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Nonlinear-optical spectroscopic techniques that employ signals from the molecules located inside nanopores have promising potential for investigations of fluid behavior under nanoconfinement. Here, we apply coherent anti-Stokes spectroscopy to investigate the appearance of a liquid-like phase of carbon dioxide in mesoporous Vycor glass under isothermal compression. The spectra of the Q-branch (1388 cm −1 ) are registered at −11 °C in a wide pressure range, starting from submonolayer coverage of the pore wall up to the bulk saturation pressure. Results show that a spectral contribution, similar to that of the bulk liquid, appears at relatively low pressure that is several times lower than the capillary-condensation pressure. The Raman shift of the peak is equal to that of the bulk liquid, although the linewidth is somewhat increased. The peak is attributed to the layers adsorbed beyond the monolayer or to small liquid-like clusters appearing in specific areas of the porous network. The spectroscopic approach presented here demonstrates the ability to detect and estimate small amounts of the liquid-like phase and to distinguish it from the layers strongly interacting with the pore surface.

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Mesoporous Silica

Ueno

2019

ANAL. SCI.

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Mesoporous silica (MS), which provides highly ordered, scalefine tunable mesopores (pore diameter of from 2 to 50 nm) and nanopores (pore diameter smaller than 2 nm), has excellent properties. These include an extremely large surface area (∼1000 m 2 /g), high thermal stability (∼900 C), and transparency to visible light. 1 The most significant property of MS concerns its controllable and uniform porosity, because the utility of porous materials is largely due to the structure and size of their pores. Highly ordered porous structures are synthesized using a surfactant, such as block copolymers, as a template for pores that form a periodic structure in a self-organizing manner in a solution. 2,3 It has been about thirty years since Yanagisawa et al. first reported the synthesis of MS in 1990 (pore diameter of from 1.8 to 3.2 nm), 3 but it has still attracted considerable interest in many different fields due to its great potential for wide ranging applications. These include separation, catalytic processes, molecular supports, chemical reaction fields, adsorbents, and sensors. For these applications, it is significant to understand any difference in the molecular behaviors between in pores and in the bulk phase. MS is synthesized in various forms: powder, thin-films, fibers, rods, monoliths, and spheres. Recently, Ohta et al. reported on a pore-size effect on a formation of pharmaceutical crystals from solution incorporated in the pores of MS by using Raman spectroscopy. 5 Because MS exhibits an excellent transmittance in the visible wavelength region, it enables us to perform optical measurements of molecules in the pores of MS. Sato et al. reported on the diffusion of fluorescent dye in a micrometer-sized spherical MS particle by using confocal fluorescence micro spectroscopy.

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Raman Spectroscopy of Pharmaceutical Cocrystals in Nanosized Pores of Mesoporous Silica

Cited by 4 publications

References 30 publications

Drug-Coformer Loaded-Mesoporous Silica Nanoparticles: A Review of the Preparation, Characterization, and Mechanism of Drug Release

Drug-Coformer Loaded-Mesoporous Silica Nanoparticles: A Review of the Preparation, Characterization, and Mechanism of Drug Release

CARS detection of liquid-like phase appearance in small mesopores

Mesoporous Silica

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