Raman spectroscopy in oral cavity and oropharyngeal cancer: a systematic review

Faur, Cosmin Ioan; Fălămaș, Alexandra; Chirilă, Magdalena; Roman, Călin Rareş; Rotaru, Horaţiu; Moldovan, Mădălina Anca; Albu, Silviu; Băciuţ, Mihaela; Robu, I.; Hedeșiu, Mihaela

doi:10.1016/j.ijom.2022.02.015

Cited by 10 publications

(6 citation statements)

References 74 publications

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“…These techniqques can provide real time reassurance that maximum pathology removal has occurred in an anatomically complex surgical field. There are a large assortment of techniques currently utilised within the UK, including Lugol's iodine [18,19], fluorescence molecular imaging and molecular margin analysis [20,21], Raman spectroscopy [22], narrow band imaging [23], optical coherence tomography [24], laser C02 piecemeal resection [25] and cytological bone margin analysis [15,26]. The intelligent knife (iKnife) is already utilised in other oncological surgical fields [27,28], utilising rapid evaporative ionisation mass spectrometry (REIMS) to discriminate between healthy, preinvasive and invasive carcinoma tissue.…”

Section: Discussionmentioning

confidence: 99%

Prognostic factors in oral cancer surgery - results from a UK tertiary centre

Kanatas¹,

Walshaw²,

Wu³

et al. 2023

European Journal of Surgical Oncology

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Section: Discussionmentioning

confidence: 99%

Prognostic factors in oral cancer surgery - results from a UK tertiary centre

Kanatas¹,

Walshaw²,

Wu³

et al. 2023

European Journal of Surgical Oncology

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“…A recently published systematic review reported on a large number of biomolecules (e.g., lipids, proteins, DNA, b-carotene, and amino acids, such as phenylalanine, tryptophan, and tyrosine), discriminating cancer from healthy tissue in certain circumstances [ 77 , 78 ]. These biomolecules may provide the opportunity to detect oral cancer at an early stage, reveal malignant transformation or recurrence, or evaluate the resection margin [ 70 , 79 , 80 , 81 ].…”

Section: Spectroscopy For the Intraoperative Assessment Of The Resect...mentioning

confidence: 99%

Intraoperative Assessment of Resection Margin in Oral Cancer: The Potential Role of Spectroscopy

Vlocskó,

Piffkó,

Janovszky

2023

Cancers

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In parallel with the increasing number of oncological cases, the need for faster and more efficient diagnostic tools has also appeared. Different diagnostic approaches are available, such as radiological imaging or histological staining methods, but these do not provide adequate information regarding the resection margin, intraoperatively, or are time consuming. The purpose of this review is to summarize the current knowledge on spectrometric diagnostic modalities suitable for intraoperative use, with an emphasis on their relevance in the management of oral cancer. The literature agrees on the sensitivity, specificity, and accuracy of spectrometric diagnostic modalities, but further long-term prospective, multicentric clinical studies are needed, which may standardize the intraoperative assessment of the resection margin and the use of real-time spectroscopic approaches.

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“…Furthermore, the minimal interference from water with the fingerprint region makes it very suitable for in situ biomolecular sample analysis and detection in various medical fields. For instance, it was used as an effective diagnosis tool for oral diseases such as dental caries, oral cancer lesions [69,70], gingivitis, or periodontitis [71]. The ability of RS to accurately and non-invasively identify the biochemical differences between the healthy and pathological statuses of tissues made it very popular in the diagnosis of different types of cancer [71][72][73][74][75][76].…”

Section: Raman and Sers-spectroscopy-based Monitoring Of Main Nd Biom...mentioning

confidence: 99%

A Review on Integrated ZnO-Based SERS Biosensors and Their Potential in Detecting Biomarkers of Neurodegenerative Diseases

et al. 2023

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Surface-enhanced Raman spectroscopy (SERS) applications in clinical diagnosis and spectral pathology are increasing due to the potential of the technique to bio-barcode incipient and differential diseases via real-time monitoring of biomarkers in fluids and in real-time via biomolecular fingerprinting. Additionally, the rapid advancements in micro/nanotechnology have a visible influence in all aspects of science and life. The miniaturization and enhanced properties of materials at the micro/nanoscale transcended the confines of the laboratory and are revolutionizing domains such as electronics, optics, medicine, and environmental science. The societal and technological impact of SERS biosensing by using semiconductor-based nanostructured smart substrates will be huge once minor technical pitfalls are solved. Herein, challenges in clinical routine testing are addressed in order to understand the context of how SERS can perform in real, in vivo sampling and bioassays for early neurodegenerative disease (ND) diagnosis. The main interest in translating SERS into clinical practice is reinforced by the practical advantages: portability of the designed setups, versatility in using nanomaterials of various matter and costs, readiness, and reliability. As we will present in this review, in the frame of technology readiness levels (TRL), the current maturity reached by semiconductor-based SERS biosensors, in particular that of zinc oxide (ZnO)-based hybrid SERS substrates, is situated at the development level TRL 6 (out of 9 levels). Three-dimensional, multilayered SERS substrates that provide additional plasmonic hot spots in the z-axis are of key importance in designing highly performant SERS biosensors for the detection of ND biomarkers.

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Raman spectroscopy in oral cavity and oropharyngeal cancer: a systematic review

Cited by 10 publications

References 74 publications

Prognostic factors in oral cancer surgery - results from a UK tertiary centre

Prognostic factors in oral cancer surgery - results from a UK tertiary centre

Intraoperative Assessment of Resection Margin in Oral Cancer: The Potential Role of Spectroscopy

A Review on Integrated ZnO-Based SERS Biosensors and Their Potential in Detecting Biomarkers of Neurodegenerative Diseases

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